Sophie's Hope Foundation Inc
Sophie's Hope Foundation's mission is to help find a cure for gsd 1b. We believe we can accomplish this by funding research and by coordinating the collaboration of patients, caregivers, doctors, researchers, and drug companies.
Sophie's Hope Foundation Inc at a glance
In short: Sophie's Hope Foundation Inc gave $133K across 2 grants in 2025 (avg $67K), mostly in North Carolina. Source: 2025 IRS Form 990.
- Annual giving (2025)
- $133,472
- +255.2% vs 2024
- Grants made (2025)
- 2
- +100.0% vs 2024
- Average grant
- $66,736
- +77.6% vs 2024
- Median grant
- $66,736
- Total assets
- $844,068
- +1.0% vs 2024
- Primary geography
- North Carolina (56% of itemized 2025 grant dollars)
- Latest 990 filing
- Form 990, 2025 View filing
Data from IRS Form 990, 2025; updated September 2026.
Who Sophie's Hope Foundation Inc funds
How this funder distributes its grants
Top Recipients
Top 2 recipients in 2025
The largest 2025 recipient was Duke University ($75K). Together the top 2 received $133K.
Grant Size Distribution
4 grants across all recorded years
The most common grant size was under $50K: 2 grants of 4 (50%).
Geographic Focus
Where this funder awards grants
Grant Distribution by State
Share of 2025 grant dollars across all 2 itemized grants.
States
Cities
How Sophie's Hope Foundation Inc gives
- Giving grew 256% from 2022 to 2025. Method
From the foundation's IRS Form 990 filings. Methodology.
Giving History
Giving Over Time
Total grant dollars and number of grants per year
From 2021 to 2025, annual grant giving ranged from $13K (2021) to $133K (2025). In 2025 it made 2 grants totaling $133K.
Hatched bars: grants paid as reported on the IRS filing, which lists no individual grants for that year.
Grants by year
Grant recipients and amounts by year
| Recipient | Purpose | Amount |
|---|---|---|
| Duke University Durham, NC | Duke Retrospective Natural History Study | $75,156 |
| University of Texas Health Science Center at Houston Houston, TX | Prospective Natual History Study Grant | $58,316 |
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Financial History
Multi-year comparison from IRS filings
| Filing year | Total Assets | Revenue | Expenses | Grants paid | Grants | Net Investment Income |
|---|---|---|---|---|---|---|
| 2025 | $844,068 | $346,140 | $337,548 | $133,472 | 2 | $9,846 |
| 2024 | $835,476 | $424,774 | $242,400 | $37,578 | 1 | $8,822 |
| 2023 | $653,102 | $329,408 | $195,191 | — | — | $6,939 |
| 2022 | $518,885 | $252,400 | $58,651 | $37,538 | 1 | $1,951 |
| 2021 | $325,136 | $248,224 | $29,713 | $13,333 | Total only | $93 |
| 2020 | $106,625 | $107,913 | $1,288 | — | — | — |
"Total only": grants paid as reported on the IRS filing, which lists no individual grants for that year.
About Sophie's Hope Foundation Inc
Based on IRS filings
Sophie's Hope Foundation Inc is a public charity focused on Medical Research, based in Hopkinton, MA. IRS filing data is available from 2020 through 2025. As of 2025, the organization holds $844K in total assets. In 2025, it awarded 2 grants totaling $133K. Net investment income was $10K.
Focus Areas
Leadership & Key People
Officers and directors from IRS filings
Sophie's Hope Foundation Inc is led by Jamas Lafreniere, President on every filing since 2020; none of the 3 officers listed in 2025 report compensation.
Officers on the 2025 filing
Jamas Lafreniere
President
On filings since 2020
15 hrs/week
No compensation reported
Brett Adamczyk
Treasurer
On filings since 2020
5 hrs/week
No compensation reported
Joseph Barberio
Clerk
On filings since 2020
5 hrs/week
No compensation reported
Data from IRS Form 990 filings, 2020–2025. "On filings since" is the earliest filing we hold that lists the person; hours are average hours per week as reported.
Frequently asked questions about Sophie's Hope Foundation Inc
How much does Sophie's Hope Foundation Inc give each year?
Sophie's Hope Foundation Inc gave $133K across 2 grants in 2025, according to its 2025 IRS Form 990. In 2024 it gave $38K across 1 grant.
How large is Sophie's Hope Foundation Inc?
Sophie's Hope Foundation Inc reported $844K in total assets on its 2025 IRS Form 990. Its revenue that year was $346K.
What is Sophie's Hope Foundation Inc?
Sophie's Hope Foundation Inc is a public charity focused on Medical Research, based in Hopkinton, MA. It holds $844K in total assets as of 2025.
Where does Sophie's Hope Foundation Inc operate?
Sophie's Hope Foundation Inc has awarded grants in North Carolina, Texas.
What is Sophie's Hope Foundation Inc's EIN?
Sophie's Hope Foundation Inc's EIN (Employer Identification Number) is 84-5014314. IRS Form 990 filing data is available on this page for 2020–2025.
Data last updated September 2026. Sourced from IRS Form 990 filings.
Data update history
(6)
When this profile's IRS filing data changed on Grantable
- Updated Form 990-EZ for fiscal year 2020 (received by the IRS January 31, 2022)
- Updated Form 990 for fiscal year 2021 (received by the IRS December 6, 2022)
- Updated Form 990 for fiscal year 2022 (received by the IRS February 17, 2023)
- Updated Form 990 for fiscal year 2024 (received by the IRS February 22, 2025)
- Updated Form 990 for fiscal year 2025 (received by the IRS February 16, 2026)
- IRS filings on file for fiscal years 2020–2025
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