Diseases, Disorders & Medical Disciplines Foundations & Grantmakers
754 grantmakers focused on diseases, disorders & medical disciplines reported grants on their latest 990s. The 190 that made at least 5 grants gave $905.2M. The largest by giving are American Heart Association Inc, Cystic Fibrosis Foundation and Breakthrough T1D. The list below ranks grantmakers with at least 5 grants by annual giving, and each funder links to a profile with its grant history and financials.
Giving at a glance
Active grantmakers
754
reported grants on latest 990
Annual giving
$905.2M
from the 190 with 5+ grants
Typical grant
$34K
median of each funder's average grant
Median annual giving
$81K
per grantmaker
Top 10 funders by annual giving
| # | Funder | Location | Annual giving | Grants |
|---|---|---|---|---|
| 1 | American Heart Association Inc | Dallas, TX | $198.2M | 833 |
| 2 | Cystic Fibrosis Foundation | Bethesda, MD | $189.6M | 624 |
| 3 | Breakthrough T1D | New York, NY | $79.3M | 100 |
| 4 | Alzheimer's Disease & Related Disorders Association Inc | Chicago, IL | $73.3M | 79 |
| 5 | Blood Cancer United Inc | Washington, DC | $47.7M | 67 |
| 6 | AIDS Foundation of Chicago | Chicago, IL | $27.1M | 46 |
| 7 | American Diabetes Association | Arlington, VA | $26.5M | 241 |
| 8 | The Mark Foundation for Cancer Research (US) Ltd | New York, NY | $19.5M | 29 |
| 9 | NFX | Detroit, MI | $14.7M | 18 |
| 10 | American Lung Association | Chicago, IL | $13.5M | 51 |
Ranked by grants reported on each funder's latest 990. Only grantmakers with at least 5 grants are ranked; 3 organizations that reported large giving in fewer grants (usually one transfer to an affiliated charity) are left out.
Where these funders are based
- California 75 · $20.9M
- New York 73 · $132.2M
- Florida 54 · $1.0M
- Illinois 52 · $141.0M
- Texas 39 · $205.6M
- Pennsylvania 39 · $10.0M
Source: IRS Form 990 and 990-PF filings, latest available year per organization (most of the largest funders' latest filing: tax year 2025).
Showing 190 grantmakers with 5+ grants on their latest 990, most giving first
American Heart Association Inc
Dallas, TX
Assets
$2.0B
Grants
833
Total Given
$198.2M
Cystic Fibrosis Foundation
Bethesda, MD
Assets
$5.0B
Grants
624
Total Given
$189.6M
Breakthrough T1D
New York, NY
Assets
$534.6M
Grants
100
Total Given
$79.3M
Alzheimer's Disease & Related Disorders Association Inc
Chicago, IL
Assets
$523.7M
Grants
79
Total Given
$73.3M
Blood Cancer United Inc
Washington, DC
Assets
$532.2M
Grants
67
Total Given
$47.7M
AIDS Foundation of Chicago
Chicago, IL
Assets
$21.7M
Grants
46
Total Given
$27.1M
American Diabetes Association
Arlington, VA
Assets
$253.9M
Grants
241
Total Given
$26.5M
The Mark Foundation for Cancer Research (US) Ltd
New York, NY
Assets
$105.5M
Grants
29
Total Given
$19.5M
NFX
Detroit, MI
Assets
$10.3M
Grants
18
Total Given
$14.7M
American Lung Association
Chicago, IL
Assets
$225.7M
Grants
51
Total Given
$13.5M
Crohn's & Colitis Foundation Inc
New York, NY
Assets
$50.6M
Grants
75
Total Given
$13.0M
Muscular Dystrophy Association Inc
Chicago, IL
Assets
$50.9M
Grants
193
Total Given
$12.6M
Melanoma Research Alliance Foundation
Washington, DC
Assets
$25.2M
Grants
29
Total Given
$11.9M
Joslin Diabetes Center Inc
Charlestown, MA
Assets
$182.7M
Grants
23
Total Given
$11.1M
Curebound
San Diego, CA
Assets
$11.9M
Grants
11
Total Given
$10.2M
Hemophilia of Georgia Inc
Sandy Springs, GA
Assets
$121.1M
Grants
30
Total Given
$8.7M
Townebank Foundation
Suffolk, VA
Assets
$20.0M
Grants
178
Total Given
$8.3M
Knights Templar Eye Foundation
Flower Mound, TX
Assets
$201.3M
Grants
45
Total Given
$6.2M
Elton John AIDS Foundation Inc
New York, NY
Assets
$37.4M
Grants
20
Total Given
$5.9M
American Society of Clinical Oncology Inc
Alexandria, VA
Assets
$321.7M
Grants
19
Total Given
$5.2M
The Bower Foundation
Ridgeland, MS
Assets
$134.2M
Grants
51
Total Given
$5.1M
March of Dimes Inc
Arlington, VA
Assets
$64.2M
Grants
24
Total Given
$4.4M
American Parkinson Disease Assoc
Staten Island, NY
Assets
$35.3M
Grants
57
Total Given
$4.4M
American Academy of Neurology Institute
Minneapolis, MN
Assets
$130.2M
Grants
21
Total Given
$4.1M
Here's the math on clicking through this list.
You, clicking into all 24 funders
~2.8 hrs
at ~7 min per funder profile
Your agents, the same 24
~1 min
every profile evaluated and scored, with reasoning
Frequently asked questions
What are the largest diseases, disorders & medical disciplines foundations?
By grants reported on their latest 990s, the largest are American Heart Association Inc ($198.2M across 833 grants), Cystic Fibrosis Foundation ($189.6M) and Breakthrough T1D ($79.3M). Together the top 10 account for 76% of the $905.2M given by the 190 grantmakers focused on diseases, disorders & medical disciplines that made at least 5 grants. Organizations that reported large giving in fewer grants, usually a single transfer to an affiliated charity, are left out of the ranking.
How big is a typical grant from these funders?
The typical grant is about $34K (the median of each grantmaker's average grant). Half of these grantmakers gave less than $81K in total in their latest filing year, so many are small foundations that give to a few organizations they already know. The largest funders make many more grants, but also get the most requests.
Where are these funders based?
Most are in California (75), New York (73) and Florida (54). Many foundations only fund near where they are based, so check each funder's giving geography before you apply.
How do I find which of these funders accept unsolicited proposals?
Most private foundations don't run an open application. Their 990-PF says whether they only give to preselected charities, and their past grants show who they actually fund. Start with the funders above whose grant counts and typical grant size fit your budget, then check each profile's grant history for organizations like yours before you reach out. Read the grant prospecting guide.
Related guides
- Grant prospecting: how to find funders that fit
How to shortlist foundations like these from their 990s and giving history.
- AI grant writing: draft proposals in your voice
Turn a shortlist into LOIs and proposals drafted from your own materials.