United Way of Pickens County

Duke Energy Foundation

Charlotte, NC

The Duke Energy Foundation funds workforce development, local economic development and recovery, disaster resilience, conservation, and economic opportunity in communities across North Carolina, South Carolina, Florida, Ohio, Kentucky, and Indiana. It reports more than $30 million in annual charitable grants; awards vary widely, with a 2024 median of $25,000, and applications of $20,000 or less are accepted on a rolling basis. Applicants should contact their local Foundation representative before applying.

The Reserve at Lake Keowee Charitable Foundation

Sunset, SC

The Reserve at Lake Keowee Charitable supports local efforts to end hunger, create safe spaces, and promote lifelong learning, including food assistance, shelter and recovery services, and scholarships and learning programs. It focuses on Pickens County, South Carolina; its 2025 grants ranged from $10,000 to $161,129, with a median of $25,000. Its website does not specify an application process for grants.

United Bank Upstate SC Foundation

Greer, SC

Ruth B Wood Foundation Inc

Clemson, SC

The Ruth B Wood Foundation supports a range of charitable organizations, including those focused on health care, childcare, basic needs, education, and local history. Its 2025 grants ranged from $500 to $5,000, with a median of $2,000; most funding went to South Carolina, with grants also made in several other states. The filing says to submit materials in writing but does not state whether unsolicited requests are accepted.

Scsymmes Foundation

Saint Louis, MO

The foundation supports charitable, educational, and cultural work that improves quality of life in Greenville County, South Carolina, including impactful projects and capital improvements. Recent grants ranged from $2,500 to $100,000, with a median of $50,000. It accepts online applications from eligible tax-exempt nonprofits; the profile says giving is not limited to preselected organizations.

The David E Maguire Foundation Inc

Wilmington, DE

The David E Maguire Foundation supports preselected charities working in areas including arts, health care, and family support, with recent grants concentrated in South Carolina and North Carolina and others in Arizona, Colorado, and Oregon. Its 2025 grants ranged from $2,000 to $30,000, with a median of $5,000. It does not accept unsolicited funding requests.

Neale Family Foundation Northern Trust NA AS

Chicago, IL

The foundation supports children’s services, food assistance, housing, health, and community programs, with 2025 grants going to organizations in Colorado, South Carolina, Indiana, Maryland, and Texas. Grants ranged from $1,000 to $25,000, with a median of $12,250. It funds only preselected organizations and does not accept unsolicited requests.

St Francis Hospital Inc

Greenville, SC

St Francis Hospital Inc supports health and community services for people in need, including medical care, housing and homelessness initiatives, and services for children with disabilities. In 2024, it made 22 grants totaling $443,943, typically around $13,000 (with awards ranging from $5,250 to $80,000), primarily in the Greenville, South Carolina area. The profile does not state whether it accepts unsolicited requests.

AWT Family Foundation

Wilmington, DE

The foundation supports education, community services, and other charitable work, including organizations serving people with disabilities. Its 2025 grants ranged from $3,000 to $125,000, with a median of $10,000; most funding went to South Carolina, with additional grants in North Carolina, Georgia, Indiana, and New York. It gives only to preselected organizations and does not accept unsolicited requests.

The Wayne & Pauline Thrift Family

Seneca, SC

The foundation supports a broad range of charitable causes, including education, health, churches, youth programs, animal welfare, and community services, with most funding going to South Carolina. Its 2025 grants ranged from $500 to $26,250, with a median of $1,000. It does not accept unsolicited requests and gives only to preselected organizations.

Oconee Federal Charitable Foundation

Seneca, SC

The Oconee Federal Charitable Foundation supports charitable organizations in areas including health, human services, education, disability services, and the arts, primarily in South Carolina, with some grants in Georgia. Its 2024 grants ranged from $1,000 to $32,500, with a median of $5,000; it does not accept unsolicited requests and gives only to preselected organizations.

Sisters of Charity Foundation of South Carolina

Cleveland, OH

The Sisters of Charity Foundation of South Carolina funds nonprofits and coalitions serving South Carolina, focusing on systems change in economic mobility and housing security, plus community engagement activities; health care systems change grants are by invitation only. Recent grants ranged from $5,500 to $100,000, with a median of $25,000; current Systems Change grants offer up to $75,000 annually for local or regional work or $100,000 for state-level work, while Community Engagement grants are up to $1,500. Systems Change Grants currently accept Letters of Intent through an inquiry process; unsolicited requests for health care grants are not accepted.