United Bank Upstate SC Foundation

Duke Energy Foundation

Charlotte, NC

The Duke Energy Foundation funds workforce development, local economic development and recovery, disaster resilience, conservation, and economic opportunity in communities across North Carolina, South Carolina, Florida, Ohio, Kentucky, and Indiana. It reports more than $30 million in annual charitable grants; awards vary widely, with a 2024 median of $25,000, and applications of $20,000 or less are accepted on a rolling basis. Applicants should contact their local Foundation representative before applying.

United Way of Greenville County Inc

Greenville, SC

United Way of Greenville County funds multi-year grants to organizations addressing poverty through affordable housing, childcare, postsecondary education and job credentials, and transportation. Its 2024 grants ranged from $5,118 to $252,389, with a median of $35,000; funding focuses on organizations serving Greenville County, South Carolina. The current grant cycle is closed, and the next is expected in 2026; the profile does not state whether unsolicited requests are accepted.

Enterprise Holdings Foundation

Saint Louis, MO

Enterprise Holdings Foundation supports nonprofits in health, education, arts, disaster relief, reforestation, hunger relief, and community equity, with an emphasis on organizations actively supported by Enterprise employees and their families. Its reported grants range widely: 2024 giving averaged about $7,700 across 9,499 grants, while the foundation also offers awards of up to $40,000; it supports communities where Enterprise operates worldwide. Unsolicited requests are accepted at any time, but eligible applications must be submitted by an Enterprise team member or their spouse or domestic partner on behalf of a nonprofit they actively support.

John I Smith Charities Inc

Greer, SC

John I Smith Charities supports a range of educational, human-service, and religiously affiliated organizations, primarily in South Carolina, with additional grants in Georgia and North Carolina. Its 2025 grants ranged from $5,000 to $100,000, with a median of $25,000. The foundation accepts inquiries by contacting Jefferson V Smith Jr.; no application form or deadline is specified.

Scansource Charitable Foundation

Greenville, SC

The foundation funds services for underrepresented children, PreK–12 education, and community-based family support, including children’s basic needs, family well-being, and education or workforce programs. Grants typically have a median of $3,750, though 2025 awards ranged from $150 to $50,000, for organizations serving communities in its listed U.S. footprint. It accepts online applications from eligible 501(c)(3) organizations; the application window is March 1–September 30.

Prisma Health

Greenville, SC

PRISMA HEALTH funds health care, health access and disparities, community engagement, and related educational and community programs, primarily in South Carolina. In 2025, it made 76 grants ranging from $5,250 to $38.7 million, with a median grant of $15,000. The available information does not state whether it accepts unsolicited requests.

Scsymmes Foundation

Saint Louis, MO

The foundation supports charitable, educational, and cultural work that improves quality of life in Greenville County, South Carolina, including impactful projects and capital improvements. Recent grants ranged from $2,500 to $100,000, with a median of $50,000. It accepts online applications from eligible tax-exempt nonprofits; the profile says giving is not limited to preselected organizations.

Robert and Ruth K Lee Foundation

Saint Louis, MO

Phillips Foundation

Greer, SC

The Jolley Foundation

Greenville, SC

The Jolley Foundation funds community-led work addressing the root causes and effects of poverty and discrimination, including racial and social justice, advocacy, capacity-building, and equitable economic development. Its primary focus is Greenville County, South Carolina; recent grants ranged from $1,555 to $150,000, with a median of $30,000.

CBL State Savings Bank Foundation

Greer, SC

The foundation funds Greer, South Carolina, community organizations and scholarships, with recent grants supporting education, community services, and other charitable causes. Its 2025 grants ranged from $1,000 to $18,000, with a median of $5,000. It does not limit giving to preselected organizations; its filing directs applicants to attached materials and lists no deadline.

Don Waggoner & Zelma Waggoner Foundation

Naples, FL

The foundation supports a range of charitable organizations, including churches, universities, Habitat for Humanity affiliates, food banks, and community organizations, with most 2024 grant dollars going to Tennessee and South Carolina, followed by Florida. Grants ranged from $1,000 to $2 million, with a median of $35,335. It funds only preselected organizations and does not accept unsolicited requests.