CBL State Savings Bank Foundation

United Way of Greenville County Inc

Greenville, SC

United Way of Greenville County funds multi-year grants to organizations addressing poverty through affordable housing, childcare, postsecondary education and job credentials, and transportation. Its 2024 grants ranged from $5,118 to $252,389, with a median of $35,000; funding focuses on organizations serving Greenville County, South Carolina. The current grant cycle is closed, and the next is expected in 2026; the profile does not state whether unsolicited requests are accepted.

Spartanburg County Foundation

Spartanburg, SC

The Spartanburg County Foundation funds nonprofits serving Spartanburg County residents, especially work advancing quality of life, education, economic mobility, and nonprofit capacity. Itemized grants had a median award of $15,500, though amounts varied widely; the information provided does not state whether it accepts unsolicited requests.

Duke Energy Foundation

Charlotte, NC

The Duke Energy Foundation funds workforce development, local economic development and recovery, disaster resilience, conservation, and economic opportunity in communities across North Carolina, South Carolina, Florida, Ohio, Kentucky, and Indiana. It reports more than $30 million in annual charitable grants; awards vary widely, with a 2024 median of $25,000, and applications of $20,000 or less are accepted on a rolling basis. Applicants should contact their local Foundation representative before applying.

Scansource Charitable Foundation

Greenville, SC

The foundation funds services for underrepresented children, PreK–12 education, and community-based family support, including children’s basic needs, family well-being, and education or workforce programs. Grants typically have a median of $3,750, though 2025 awards ranged from $150 to $50,000, for organizations serving communities in its listed U.S. footprint. It accepts online applications from eligible 501(c)(3) organizations; the application window is March 1–September 30.

John I Smith Charities Inc

Greer, SC

John I Smith Charities supports a range of educational, human-service, and religiously affiliated organizations, primarily in South Carolina, with additional grants in Georgia and North Carolina. Its 2025 grants ranged from $5,000 to $100,000, with a median of $25,000. The foundation accepts inquiries by contacting Jefferson V Smith Jr.; no application form or deadline is specified.

Sisters of Charity Foundation of South Carolina

Cleveland, OH

The Sisters of Charity Foundation of South Carolina funds nonprofits and coalitions serving South Carolina, focusing on systems change in economic mobility and housing security, plus community engagement activities; health care systems change grants are by invitation only. Recent grants ranged from $5,500 to $100,000, with a median of $25,000; current Systems Change grants offer up to $75,000 annually for local or regional work or $100,000 for state-level work, while Community Engagement grants are up to $1,500. Systems Change Grants currently accept Letters of Intent through an inquiry process; unsolicited requests for health care grants are not accepted.

United Bank Upstate SC Foundation

Greer, SC

The Jolley Foundation

Greenville, SC

The Jolley Foundation funds community-led work addressing the root causes and effects of poverty and discrimination, including racial and social justice, advocacy, capacity-building, and equitable economic development. Its primary focus is Greenville County, South Carolina; recent grants ranged from $1,555 to $150,000, with a median of $30,000.

Scsymmes Foundation

Saint Louis, MO

The foundation supports charitable, educational, and cultural work that improves quality of life in Greenville County, South Carolina, including impactful projects and capital improvements. Recent grants ranged from $2,500 to $100,000, with a median of $50,000. It accepts online applications from eligible tax-exempt nonprofits; the profile says giving is not limited to preselected organizations.

Gerrish H Milliken Foundation 009209-009

Wilmington, DE

The Gerrish H. Milliken Foundation funds charitable organizations in areas including health care, housing, education, community development, libraries, and wildlife care, with the largest share of its 2025 giving going to Maine. It made 121 grants totaling $582,500, ranging from $500 to $30,000, with a median grant of $4,000. It does not accept unsolicited requests and gives only to preselected organizations.

Central Carolina Community

Columbia, SC

Central Carolina Community funds education, human services, health, arts and culture, community development, disaster relief, and nonprofit capacity-building, primarily in the 11-county Midlands region of South Carolina, with some statewide and national grantmaking. Its 2025 grants had a median of $20,000; eligible nonprofits may apply through the online portal during published grant periods, though some opportunities are invitation-only.

Coastal Community Foundation of South

N Charleston, SC

The Coastal Community Foundation of South Carolina funds nonprofits through competitive grants for areas including education, health, community development, arts, and human needs. Its 2024 grants had a median of $16,500, with awards ranging from $5,057 to $2.3 million, across nine coastal South Carolina counties. It accepts applications only for listed competitive programs, through its online portal.