Prairie Lakes Health Care System Inc

First Interstate BancSystem Foundation

Billings, MT

The First Interstate BancSystem Foundation funds poverty reduction, youth development, financial education, and community development, as well as civic, arts, education, health, human services, and sustainability efforts in communities served by First Interstate Bank across 10 states. Its 2025 grants had a median award of $2,500, though amounts varied widely; the stated minimum grant is $2,500. Organizations can submit grant requests online, which are traditionally reviewed monthly, but grants must be recommended by a local First Interstate branch.

South Dakota Community Foundation

Pierre, SD

The South Dakota Community Foundation funds nonprofits and charitable projects in areas including education, health, human services, culture, and economic development, primarily benefiting South Dakota communities. Its 2024 grants had a median of $18,562, while 2026 Beyond Idea Grants range from $5,000 to $100,000 per year. Eligible nonprofits can apply for South Dakota Fund and Beyond Idea Grants through its online portal.

Duke Family Foundation

Rapid City, SD

Cystic Fibrosis Foundation

Bethesda, MD

The Cystic Fibrosis Foundation funds cystic fibrosis research, drug development, specialized care, and related training and clinical programs. In 2024, its grants had a median of about $150,000, with awards ranging from $2,800 to nearly $12.9 million; it supports work nationwide. Applications are submitted through specific funding opportunities, but the profile does not state whether unsolicited requests are accepted.

Human Service Agency Foundation

Watertown, SD

The foundation is organized for charitable and educational purposes, including making distributions to the human services agency and similar organizations organized and operated exclusively for charitable, religious, educational, or scientific purposes as shall at the time qualify as an exempt organization under section 501(c)(3).

C E Richardson Benevolent Foundation

Pulaski, VA

The C E Richardson Benevolent Foundation funds Virginia nonprofits addressing needs such as education, food assistance, emergency services, health care, and community programs, primarily within 30 miles of either side of I-81 from Lexington to Abingdon. Recent grants ranged from $1,000 to $25,000, with a median of $5,880. It accepts written applications once a year, approximately August 15–September 15; applicants must request a new application form from the foundation office.

Rock Club

Radford, VA

Gannett Foundation Inc

New York, NY

Gannett Foundation’s 2025 grants supported a range of organizations, with listed awards generally between $1,500 and $2,500, though the available figures do not establish a typical grant size or geographic focus. The foundation has wound down: its 2026 filing reports no grants or assets, and no current application process or acceptance of unsolicited requests is stated.

Sioux Falls Area Community Foundation Inc

Sioux Falls, SD

The Sioux Falls Area Community Foundation funds local charitable, educational, cultural, religious, community-development, and environmental needs, including new programs and nonprofit capacity building, primarily in the Sioux Falls area and surrounding communities. Its 2025 grants had a median of $25,000, though awards varied widely; organizations may submit a Letter of Inquiry for Community Fund Grants.

Sanford Health Foundation North

Sioux Falls, SD

Sanford Health Foundation North primarily supports Sanford Health and related organizations in patient care, family support, equipment and facilities, healthcare education, and research. Its 2024 grants ranged from $5,990 to $2,989,585, with a median of $21,500, and nearly all reported grant dollars went to South Dakota recipients, with some scholarship support in North Dakota and Minnesota. The profile does not state whether it accepts unsolicited requests.

Sanford Group Return

Sioux Falls, SD

Sanford Group Return funds health care access and outcomes, community wellbeing, workforce and education, and related community needs, including health professions education and research. In 2024, its median grant was $24,900, with awards ranging from $5,500 to $3.6 million; giving was concentrated in South Dakota, North Dakota, and Minnesota. Its Community Dividend Fund accepts online funding requests in South Dakota, Iowa, Minnesota, Montana, Nebraska, North Dakota, and Wyoming; whether unsolicited requests are accepted is not stated.

Black Hills Area Community Foundation

Rapid City, SD

The foundation funds community needs across areas including youth and families, social services, education, basic needs, arts, animal welfare, and nonprofit capacity building in seven Black Hills counties of South Dakota. Its 2025 grants had a median award of $15,000; the profile does not state whether it accepts unsolicited requests.