Threshold of Hope Inc

The Charlie & Mary Beth O'Reilly

Nixa, MO

The Charlie & Mary Beth O’Reilly supports charitable organizations in areas including human services, religion, animal welfare, and community programs, with most 2024 funding going to Missouri. Its 2024 grants ranged from $400 to $27,500, with a median of $2,000. It does not accept unsolicited requests and gives only to preselected organizations.

Community Foundation of the Ozarks Inc

Springfield, MO

The Community Foundation of the Ozarks funds projects in areas including education, health, economic development, environmental sustainability, arts, and community well-being, primarily in the Springfield area and affiliate communities across the Ozarks and southern Missouri. In 2025, its 477 grants ranged from $5,065 to $1 million, with a median of $20,000. It accepts applications for eligible programs through its grant portal; criteria and deadlines vary by program.

Enterprise Holdings Foundation

Saint Louis, MO

Enterprise Holdings Foundation supports nonprofits in health, education, arts, disaster relief, reforestation, hunger relief, and community equity, with an emphasis on organizations actively supported by Enterprise employees and their families. Its reported grants range widely: 2024 giving averaged about $7,700 across 9,499 grants, while the foundation also offers awards of up to $40,000; it supports communities where Enterprise operates worldwide. Unsolicited requests are accepted at any time, but eligible applications must be submitted by an Enterprise team member or their spouse or domestic partner on behalf of a nonprofit they actively support.

Greater Horizons

Kansas City, MO

Greater Horizons is a donor-advised fund provider whose donor-directed grants support eligible U.S. public charities across a broad range of causes; international organizations may also qualify with additional review and fees. In 2024, grants had a median of $15,000, with itemized awards ranging from $5,001 to $10,073,050, and recipients were located across the United States, especially in California, Texas, Nebraska, New York, and Kansas. It describes a grant-request process for donors, not an application process for organizations, so unsolicited requests are not stated as accepted.

St Louis Community Foundation Inc

St. Louis, MO

The St. Louis Community Foundation supports nonprofits through donor- and foundation-directed grants, with priorities including economic mobility and youth connections as well as education, health, arts, and culture. Its 2024 grants had a median of $20,000, though amounts ranged from $5,050 to $4 million; its regional priorities center on Greater St. Louis, especially designated high-need ZIP codes. Grant processes vary by fund, so the profile does not establish whether the Foundation accepts unsolicited requests generally.

Commerce Bancshares Foundation

Kansas City, MO

The foundation supports a broad range of charitable organizations and community projects, with 2024 grants typically small (median $1,500) but ranging from $200 to $60,500. Most funding went to Missouri, followed by Kansas and Illinois, with smaller amounts elsewhere; it says applicants should contact the program director and provide proof of 501(c)(3) status, and does not restrict giving to preselected organizations.

Patterson Family Foundation

Kansas City, MO

The Patterson Family Foundation funds healthcare, education, and economic opportunity, including program, operating, equipment, and capital grants for organizations serving rural communities in Kansas and western Missouri, generally in counties under 50,000 residents. Its 2021 awards ranged from $144 to $2.5 million, with a median of $6,300; it says it does not accept unsolicited funding requests and contributes only to preselected charitable organizations.

Midway USA Foundation Inc

Columbia, MO

MidwayUSA Foundation funds U.S. high school, college, and other youth shooting-sports teams and activities across all shooting disciplines; it does not support adult programs or non-U.S. teams. In 2024, grants ranged from $902 to $388,797, with a median of $10,601; team cash grants are generally 5% of an eligible program’s endowment balance, and coach-training grants are $1,000–$5,000. It accepts applications through its online system from eligible programs.

Veterans United Foundation

Columbia, MO

Veterans United Foundation supports Veterans, service members, military families, and communities where Veterans United Home Loans has offices, funding community organizations, scholarships, and individual needs. In 2025, its grants had a median of $10,000, with awards ranging from $96 to $1.2 million. Organizations may apply for donations; the profile does not specify whether unsolicited requests are accepted.

Ewing Marion Kauffman Foundation

Kansas City, MO

The Ewing Marion Kauffman Foundation funds college access and completion, workforce and career development, and entrepreneurship, with an emphasis on economic mobility and equitable opportunity in the Kansas City region. Its 2024 median grant was $75,000, though awards vary widely by program; the profile does not state whether it accepts unsolicited requests.

Washington University

Saint Louis, MO