Big Brothers Incorporated

Enterprise Holdings Foundation

Saint Louis, MO

Enterprise Holdings Foundation supports nonprofits in health, education, arts, disaster relief, reforestation, hunger relief, and community equity, with an emphasis on organizations actively supported by Enterprise employees and their families. Its reported grants range widely: 2024 giving averaged about $7,700 across 9,499 grants, while the foundation also offers awards of up to $40,000; it supports communities where Enterprise operates worldwide. Unsolicited requests are accepted at any time, but eligible applications must be submitted by an Enterprise team member or their spouse or domestic partner on behalf of a nonprofit they actively support.

Schwab-Silfen Foundation

Harrisburg, PA

The Schwab-Silfen Foundation supports a range of organizations, with 2024 grants going to groups including educational, Jewish, and emergency medical organizations. Grants ranged from $100 to $91,000, with a median of $1,000; the largest shares went to Pennsylvania, New York, and Maryland. It accepts requests at any time by letter explaining the funding need.

Bradley Family Charitable Trust

Amarillo, TX

The Joseph Henry Edmondson Foundation

Colorado Springs, CO

The Joseph Henry Edmondson Foundation funds nonprofits working in arts and education, community development, conservation and the environment, and health and human services, with much of its support for capacity building and general operations. It primarily serves Colorado Springs and the Pikes Peak Region; grants generally range from $500 to $100,000, with a stated average of $10,000. Applicants are asked to contact the foundation before applying, and it focuses on organizations with an established funding history; unsolicited public-education proposals are not considered.

First Interstate BancSystem Foundation

Billings, MT

The foundation funds poverty elimination, youth development, financial education, community development, and related community needs, including education, health, arts, and human services, in communities served by First Interstate Bank across 10 states. Its minimum grant is $2,500; the 2025 median award was $2,500, though amounts varied widely. Organizations may submit requests online, but grants are limited to organizations recommended by local First Interstate branches.

Kenneth Bankert Foundation Inc

Hummelstown, PA

The Kenneth Bankert Foundation primarily funds Central Pennsylvania organizations serving student athletes, children with cancer, veterans, people with disabilities, and children, as well as efforts to prevent child abuse; it says all requests will be considered. Recent grants ranged from $5,000 to $25,000, with a median of $15,000. Its filing says eligible 501(c)(3) organizations may submit requests, which are reviewed at quarterly meetings.

Bristol-Myers Squibb Foundation Inc

Princeton, NJ

The Bristol-Myers Squibb Foundation supports health-access initiatives for disproportionately affected populations, including cancer, blood disorders, brain health, and clinical-trial participation, in the United States and internationally. In 2024, its median grant was $134,090, though awards varied widely; it says application materials are available upon request and advises organizations to contact it about the process, but does not state whether unsolicited requests are accepted.

Greater Horizons

Kansas City, MO

Greater Horizons is a donor-advised fund provider whose donor-directed grants support eligible U.S. public charities across a broad range of causes; international organizations may also qualify with additional review and fees. In 2024, grants had a median of $15,000, with itemized awards ranging from $5,001 to $10,073,050, and recipients were located across the United States, especially in California, Texas, Nebraska, New York, and Kansas. It describes a grant-request process for donors, not an application process for organizations, so unsolicited requests are not stated as accepted.

St Louis Community Foundation Inc

St. Louis, MO

The St. Louis Community Foundation supports nonprofits through donor- and foundation-directed grants, with priorities including economic mobility and youth connections as well as education, health, arts, and culture. Its 2024 grants had a median of $20,000, though amounts ranged from $5,050 to $4 million; its regional priorities center on Greater St. Louis, especially designated high-need ZIP codes. Grant processes vary by fund, so the profile does not establish whether the Foundation accepts unsolicited requests generally.

Commerce Bancshares Foundation

Kansas City, MO

The foundation supports a broad range of charitable organizations and community projects, with 2024 grants typically small (median $1,500) but ranging from $200 to $60,500. Most funding went to Missouri, followed by Kansas and Illinois, with smaller amounts elsewhere; it says applicants should contact the program director and provide proof of 501(c)(3) status, and does not restrict giving to preselected organizations.

Patterson Family Foundation

Kansas City, MO

The Patterson Family Foundation funds healthcare, education, and economic opportunity, including program, operating, equipment, and capital grants for organizations serving rural communities in Kansas and western Missouri, generally in counties under 50,000 residents. Its 2021 awards ranged from $144 to $2.5 million, with a median of $6,300; it says it does not accept unsolicited funding requests and contributes only to preselected charitable organizations.

Midway USA Foundation Inc

Columbia, MO

MidwayUSA Foundation funds U.S. high school, college, and other youth shooting-sports teams and activities across all shooting disciplines; it does not support adult programs or non-U.S. teams. In 2024, grants ranged from $902 to $388,797, with a median of $10,601; team cash grants are generally 5% of an eligible program’s endowment balance, and coach-training grants are $1,000–$5,000. It accepts applications through its online system from eligible programs.