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RFA- Studies Addressing Clinically Relevant Questions About Ketones And The Use Of Continuous Ketone Monitoring In Type 1 Diabetes Grant

Breakthrough T1D

Funding Amount

Up to US $1,500,000

Deadline

Deadline not published

Grant Type

Foundation

Can we apply?

Check your organization against each line. Taken from the listing; confirm with the funder's guidelines.

Required status

  • 501(c)(3) tax-exempt status

Overview

Breakthrough T1D is inviting studies that address clinically relevant questions about ketones and the use of continuous ketone monitoring (CKM) in type 1 diabetes. As CKMs provide continuous data, they can enhance our understanding of ketone dynamics and their implications for diabetes management and DKA prevention. This initiative aims to foster innovative research that can lead to improved treatments and outcomes for individuals living with type 1 diabetes.

Breakthrough T1D
Founded in 1970 by families whose loved ones had been diagnosed with type 1 diabetes (T1D), Breakthrough T1D is a tax-exempt nonprofit 501(c)3 organization.
We lead the way to more effective solutions by connecting the brightest minds to advance treatments, influence policy, and improve access to care.​ By driving innovation forward, Breakthrough T1D will make type 1 diabetes a condition of the past.
Studies addressing clinically relevant questions about ketones and the use of continuous ketone monitoring in type 1 diabetes
Purpose
Circulating ketones are clinically relevant metabolites in type 1 diabetes (T1D). To date, most of our knowledge about ketones in T1D has come from point-of-care blood and urine ketone measurements, which provide only snapshots in time and lack the temporal resolution needed to fully understand ketone dynamics. Today, emerging continuous ketone monitors (CKMs) allow us to answer questions we never could before about the pathophysiology of T1D and its complications, DKA prevention, and other topics. Breakthrough T1D invites letters of intent for studies addressing clinically relevant questions about ketones and the use of CKM in T1D.

What Breakthrough T1D actually gave

Source: IRS Form 990, 2025

Grants in 2025
100
Total given
$79.32M
Median grant
$378K
Range
$25K–$7.28M
  • By dollars: Massachusetts 21%, California 13%, Florida 7%. Top recipient cities: Boston, MA; New York, NY; Seattle, WA.
  • 0% of grants with a stated purpose were for general or operating support.
  • 16% of recipients were new grantees, not repeat recipients.

Example grants

  • University of Massachusetts Medical School · Worcester, MA

    T1d research

    $7.28M

  • The Regents of the University of California San Francisco · San Francisco, CA

    T1d research

    $5.4M

  • The University of Chicago · Chicago, IL

    T1d research

    $4.12M

  • Regents of the University of Colorado · Denver, CO

    T1d research

    $3.58M

  • University of Florida · Gainesville, FL

    T1d research

    $3.13M

IRS Form 990, 2025. Amounts as reported by the funder. Full 990 history →

Focus Areas & Funding Uses

Fields of Work

  • Science research

Categories

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