How much funding does Diabetes Research Centers (P30 Clinical Trial Optional) provide?

Diabetes Research Centers (P30 Clinical Trial Optional) provides Up to $1,000,000 in funding.

When is the deadline for Diabetes Research Centers (P30 Clinical Trial Optional)?

The deadline is January 27, 2027.

Diabetes Research Centers (P30 Clinical Trial Optional)

National Institutes of Health

Federal Grants for Science Research

Apply Now

Funding Amount

Up to $1,000,000

Deadline

January 27, 2027

294 days left

Grant Type

federal

Overview

Diabetes Research Centers (P30 Clinical Trial Optional)

This Notice of Funding Opportunity (NOFO) invites applications for Diabetes Research Centers (DRCs) that are designed to support and enhance the national research effort in diabetes, its complications, and related endocrine and metabolic diseases. The purpose of this Centers program is to bring together basic and clinical investigators to enhance communication, multidisciplinary collaboration, and effectiveness of ongoing research in Diabetes Research Center topic areas. By providing shared access to specialized technical resources (research cores) and supporting a Pilot and Feasibility Program (P&F), DRCs are intended to create an environment that provides the capability for accomplishments greater than those that would be possible by individual research project grant support alone. New Center programs that bring in diverse perspectives, propose unique scientific themes, or provide innovative resources are encouraged. Emphasis will be placed on Center programs that propose enhanced synergies with other NIDDK-funded programs as well as providing a rich mentoring environment for future diabetes researchers.

Details

Agency: National Institutes of Health
Department: Department of Health and Human Services
Opportunity #: RFA-DK-26-310
Total Funding: $18,200,000
Expected Awards: 7
Instrument: grant

Eligibility

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility. Special Instructions for this NOFO: Only one application is allowed per institution.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organization) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

Eligibility

Eligible Applicant Types

nonprofits_non_higher_education_with_501c3othercity_or_township_governmentsstate_governmentspublic_and_indian_housing_authoritiesfederally_recognized_native_american_tribal_governmentspublic_and_state_institutions_of_higher_educationsmall_businessesprivate_institutions_of_higher_educationnonprofits_non_higher_education_without_501c3county_governmentsfor_profit_organizations_other_than_small_businessesspecial_district_governmentsindependent_school_districtsother_native_american_tribal_organizations

How to Apply

RFA-DK-26-310-Full-Announcement.html

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<title>RFA-DK-26-310: Diabetes Research Centers (P30 Clinical Trial Optional)</title>

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<div id="page-title" class="heading1" tabindex="0">Department of Health and Human Services</div>

<div>

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<a id='_bookmark259587' tabindex='-1' aria-hidden='true'></a><a name="_Part 1. Overview Information"></a><h1>Part 1. Overview Information</h1>
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<p>National Institutes of Health (<a href="http://www.nih.gov">NIH</a>)</p>
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<p>National Institute of Diabetes and Digestive and Kidney Diseases (<a href="https://www.niddk.nih.gov/" target="_blank" rel="noreferrer">NIDDK</a>)
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<a id='_bookmark259592' tabindex='-1' aria-hidden='true'></a>Funding Opportunity Title
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<span class="title">Diabetes Research Centers (P30 Clinical Trial Optional)</span>
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<a id='_bookmark259593' tabindex='-1' aria-hidden='true'></a>Activity Code
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<p><a href="http://grants.nih.gov/grants/funding/ac_search_results.htm?text_curr=p30&Search.x=0&Search.y=0&Search_Type=Activity">P30</a> Center Core Grants</p>
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Reissue of

<a href="https://grants.nih.gov/grants/guide/rfa-files/RFA-DK-25-008.html" target="_blank" rel="noreferrer">RFA-DK-25-008</a>

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<a id='_bookmark259595' tabindex='-1' aria-hidden='true'></a>Related Notices
</div>
<div class=" col-md-8 datacolumn">
<ul><li>Check for any recent <a href="https://grants.nih.gov/grants/guide/url_redirect.php?id=11163">Notices of NIH Policy Changes</a> that may impact application requirements.</li></ul>
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<a id='_bookmark259596' tabindex='-1' aria-hidden='true'></a>Funding Opportunity Number (FON)
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<span class="noticenum">RFA-DK-26-310</span>
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<a id='_bookmark259597' tabindex='-1' aria-hidden='true'></a>Companion Notice of Funding Opportunity
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<div class=" col-md-8 datacolumn">
None
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<p>See <a href="#_3._Additional_Information">Section III. 3. Additional Information on Eligibility</a>.  Only one application per institution is allowed, as defined in Section III. 3. Additional Information on Eligibility. </p>
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93.847
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<a id='_bookmark259600' tabindex='-1' aria-hidden='true'></a>Notice of Funding Opportunity Purpose
</div>
<div class=" col-md-8 datacolumn">
<p>This Notice of Funding Opportunity (NOFO) invites applications for Diabetes Research Centers (DRCs) that are designed to support and enhance the national research effort in diabetes, its complications, and related endocrine and metabolic diseases. The purpose of this Centers program is to bring together basic and clinical investigators to enhance communication, multidisciplinary collaboration, and effectiveness of ongoing research in Diabetes Research Center topic areas. By providing shared access to specialized technical resources (research cores) and supporting a Pilot and Feasibility Program (P&F), DRCs are intended to create an environment that provides the capability for accomplishments greater than those that would be possible by individual research project grant support alone. New Center programs that bring in new approaches, propose unique scientific themes, or provide innovative resources are encouraged. Emphasis will be placed on Center programs that propose enhanced synergies with other NIDDK-funded programs as well as providing a rich mentoring environment for future diabetes researchers.</p>
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<a id='_bookmark259602' tabindex='-1' aria-hidden='true'></a>Funding Opportunity Goal(s)
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<p>The objectives of the Diabetes Research Centers are to promote extramural preclinical and clinical biomedical research that improves our understanding of the pathogenic mechanisms underlying diabetes and related metabolic disorders leading to improved prevention, diagnosis, and treatment of diabetes and related metabolic disorders and complications.</p>
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<a id='_bookmark259603' tabindex='-1' aria-hidden='true'></a><a name="_Key Dates"></a><h2>Key Dates</h2>
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February 10, 2026
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<th scope="col" colspan="3" style="border:2px solid #bcbcbc;" class="text-center">Application Due Dates</th>
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<th scope="col" style="width:16.66%;border-left:2px solid #bcbcbc;" class="text-center">New</th>
<th scope="col" style="width:16.66%" class="text-center">Renewal / Resubmission / Revision (as allowed)</th>
<th scope="col" style="width:16.66%;border-right:2px solid #bcbcbc;" class="text-center">AIDS - New/Renewal/Resubmission/Revision, as allowed</th>
<th scope="col" style="width:16.66%" class="text-center">Scientific Merit Review</th>
<th scope="col" style="width:16.66%" class="text-center">Advisory Council Review</th>
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March 10, 2026
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March 10, 2026
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Not Applicable
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<td>July 2026</td>
<td> October 2026

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<td>December 2026</td>
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January 27, 2027
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January 27, 2027
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Not Applicable
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<td>July 2027</td>
<td> October 2027

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<td>December 2027</td>
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<a id='_bookmark259609' tabindex='-1' aria-hidden='true'></a><p>All applications are due by 5:00 PM local time of applicant organization. </p>

<p>Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.</p>
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<a id='_bookmark259614' tabindex='-1' aria-hidden='true'></a><p class="Normal">No late applications will be accepted for this Notice of Funding Opportunity (NOFO).</p>
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<a id='_bookmark259615' tabindex='-1' aria-hidden='true'></a>Expiration Date
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January 28, 2027
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<p>Not Applicable</p>
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<a id='_bookmark259617' tabindex='-1' aria-hidden='true'></a>Required Application Instructions
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<p>It is critical that applicants follow the Multi-Project (M) Instructions in the <a href="https://grants.nih.gov/grants/guide/url_redirect.htm?id=82400">How to Apply - Application Guide</a>, except where instructed to do otherwise (in this NOFO or in a Notice from the <a href="http://grants.nih.gov/grants/guide/url_redirect.htm?id=11164">NIH Guide for Grants and Contracts</a>). Conformance to all requirements (both in the <a href="https://grants.nih.gov/grants/guide/url_redirect.htm?id=82400">How to Apply - Application Guide</a> and the NOFO) is required and strictly enforced. Applicants must read and follow all application instructions in the <a href="https://grants.nih.gov/grants/guide/url_redirect.htm?id=82400">How to Apply - Application Guide</a> as well as any program-specific instructions noted in Section IV. When the program-specific instructions deviate from those in the <a href="https://grants.nih.gov/grants/guide/url_redirect.htm?id=82400">How to Apply - Application Guide</a>, follow the program-specific instructions. <b>Applications that do not comply with these instructions may be delayed or not accepted for review.</b></p>
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<a id='_bookmark262226' tabindex='-1' aria-hidden='true'></a><p style="margin-left:0in;">There are several options available to submit your application through Grants.gov to NIH and Department of Health and Human Services partners. You <strong>must</strong> use one of these submission options to access the application forms for this opportunity.</p><ol><li>Use the <a href="https://public.era.nih.gov/assist/landing.era?tabId=0819b5fc-46b7-4f02-b6b7-127e5a4e19fa">NIH ASSIST system</a> to prepare, submit and track your application online.</li><li>Use an institutional system-to-system (S2S) solution to prepare and submit your application to Grants.gov and <a href="https://public.era.nih.gov/commons/">eRA Commons</a> to track your application. Check with your institutional officials regarding availability.</li></ol>
</div>

<div id="tocDiv">
<div class="heading1" tabindex="0">Table of Contents</div>
<div class="toc-link"><a href="#_Part1.OverviewInformation">Part 1. Overview Information</a></div><div class="toc-link P_SingleIndent"><a href="#_KeyDates">Key Dates</a></div><div class="toc-link"><a href="#_Part2.FullTextofAnnouncement">Part 2. Full Text of Announcement</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionI.NoticeofFundingOpportunityDescription">Section I. Notice of Funding Opportunity Description</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionII.AwardInformation">Section II. Award Information</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionIII.EligibilityInformation">Section III. Eligibility Information</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionIV.ApplicationandSubmissionInformation">Section IV. Application and Submission Information</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionV.ApplicationReviewInformation">Section V. Application Review Information</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionVI.AwardAdministrationInformation">Section VI. Award Administration Information</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionVII.AgencyContacts">Section VII. Agency Contacts</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionVIII.OtherInformation">Section VIII. Other Information</a></div>
</div><br/>

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<a id='_bookmark259619' tabindex='-1' aria-hidden='true'></a><a name="_Part 2. Full Text of Announcement"></a><h1>Part 2. Full Text of Announcement</h1>
</div>

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<a id='_bookmark259620' tabindex='-1' aria-hidden='true'></a><a name="_Section I. Notice of Funding Opportunity Description"></a><h2>Section I. Notice of Funding Opportunity Description</h2>
</div>

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<a id='_bookmark259621' tabindex='-1' aria-hidden='true'></a><h4><strong>Background</strong></h4><p>According to the CDC, the prevalence of diabetes mellitus in the United States continues to rise over time.  It was ~14.7% of the adult population in 2021 (~38 million, or 11.6% of the US Population) and about twice that prevalence in those over 65.  Diabetes accounts for a major national burden of morbidity, mortality, and health care expenditures. Individuals with diabetes incur average health care expenditures that are around two to three times higher than those without diabetes.  Obesity is a significant risk factor for type 2 diabetes and the prevalence of obesity in adults and children in the U.S. has dramatically increased in the past four decades. Overweight, obesity, and/or excessive weight gain during pregnancy are also contributing to the rising rates of gestational diabetes mellitus (GDM) which in turn increases risk of future type 2 diabetes in the mother and child. Both type 1 and type 2 diabetes in youth are also on the rise. People with diabetes have a higher rate of cardiovascular disease along with a host of other co-morbidities including microvascular complications that may lead to kidney failure, lower limb amputation, and blindness.</p><h4 style="margin-left:0in;">Program Objectives</h4><p style="margin-left:0in;">The objectives of the Diabetes Research Centers (DRCs) include promoting preclinical, clinical and interdisciplinary biomedical research to improve our understanding of the pathogenic mechanisms underlying diabetes and related metabolic disorders.  The DRCs long-term goal is to enhance the effectiveness and synergy around research on the pathogenic mechanisms of diabetes related metabolic diseases (e.g., obesity) along with prevention of or interventions for diabetes and its complications. To accomplish this, Centers may engage scientists from interdisciplinary fields including but not limited to endocrinology, immunology, inflammation, neurosciences, pathology, genetics and other OMICs, cell biology, biostatistics, artificial intelligence, machine learning, and other fields that can be leveraged to prevent or cure diabetes, related disorders and complications.  The structure of a DRC aims to create and support a community of basic and clinical investigators, and to provide biomedical research cores and a pilot and feasibility grant program to enhance the effectiveness and synergy around this research. DRCs are meant to improve communication among investigators and to integrate, coordinate, and foster interdisciplinary research. To accomplish this mission, the Diabetes Research Centers support a group of established investigators actively conducting programs of important, high-quality research and provide the opportunity to synergize, through the DRC structure, with other NIH funded Centers and NIDDK programs at the DRC's institution and affiliated institutions if applicable. It also provides a rich environment to enhance workforce development of both preclinical and clinical investigators. The overall purpose of the Diabetes Research Centers program is to provide the capability for accomplishments greater than those that would be possible by individual research project grant support alone.</p><p style="margin-left:0in;">This Notice of Funding Opportunity (NOFO) for the Diabetes Research Centers represents a key component of the NIDDKs overall strategy to improve the health of Americans by reducing the prevalence ad impact of diabetes and related endocrine and metabolic disorders.</p><h4 style="margin-left:0in;">Structure and Activities of a DRC</h4><p style="margin-left:0in;">The DRC is composed of three components to be proposed in the application: an Administrative Core (with an Enrichment Program), at least two but not more than five Biomedical Research Cores, and a Pilot and Feasibility (P&F) Grant Program. These components are described in detail below. The DRC must be an identifiable unit within either a single institution (such as a university medical center) or a consortium of cooperating institutions. The DRC is expected to facilitate and leverage relevant expertise and collaborations leading to the formation of a community of scientists whose long-term goals are to prevent or cure diabetes and its complications. DRC applications must identify a process for designating <strong>members</strong> (as described below) whose research is focused on the proposed <strong>scientific theme or themes</strong> (as described below). Evidence should exist, that taken as a whole, the group of members have: 1) an existing strong <strong>research base</strong> of external research funding in basic and/or clinical research in diabetes and/or related areas within NIDDKs mission, (2) a consistent and outstanding record of reviewed publications related to the theme or themes, and (3) other evidence of impact on the field (e.g., participation in developing new methods or clinical guidelines, progress along the translational spectrum, national collaborations, or other evidence of health and societal impact).</p><h4 style="margin-left:0in;">The Administrative Core (includes an Enrichment Program)</h4><p style="margin-left:0in;">Each DRC must include an Administrative Core responsible for overall DRC leadership, allocation and oversight of Center resources, and to ensure the coordination and integration of DRC components and activities. Administrative Core personnel provide support for a required External Advisory Committee and the internal committee structure of the Center. The Administrative Core should have a process to <strong>a) </strong>assess the productivity, effectiveness, and appropriateness of Center activities including reviewing the biomedical research cores for utilization and feedback, and the P&F program; <strong>b) </strong>considering the criteria and selection process for Center membership and carrying out that process; <strong>c) </strong>foster collaborations and scientific opportunities among its members; and <strong>d) </strong>work with other DRCs and NIDDK Center programs and Coordinating Centers to facilitate administration of regional and/or national programs (see below section on <strong>Interaction with Coordinating Centers)</strong>. Irrespective of the leadership approach for the DRC, there should be a <strong>succession plan</strong> described in the application that will be triggered in the case that the contact PI cannot fulfill their duties for any reason.  </p><p style="margin-left:0in;">The Administrative Core must also support an <strong>Enrichment Program </strong>that is expected to be key for developing a community of diabetes researchers and growing that community over time.  It accomplishes this by providing enrichment activities that in turn foster investigator interactions leading to multidisciplinary diabetes research approaches and attract new investigators with relevant expertise to diabetes research. While many of these activities my already occur at the recipient institution, applicants are encouraged to suggest coordinated efforts, such as educational activities, that might operate on a <strong>regional or national level </strong>and involve multiple Diabetes Research Centers. Funding support for the Enrichment Program under the auspices of the Administrative Core may be requested. Support for visiting scientists, seminars, and research forums are appropriate items for inclusion in an enrichment program as well as any appropriate, innovative means to support the goals of the Center, e.g.workshops, etc.  Also, limited travel support may be requested to allow DRC investigators, particularly early-stage and junior investigators, to learn new laboratory techniques, to develop new collaborations, or to engage in scientific information exchange. In all cases, the enrichment program should further the overall aims and objectives of the DRC as well as its cores. Creative new programs, not precluded by NIH or NIDDK policies, are encouraged. While DRCs may not support stipends for graduate students or postdoctoral fellows, the environment fostered by the existence of the Center with its core facilities in conjunction with its enrichment program and educational opportunities should serve to foster the careers of students, postdoctoral fellows and junior faculty, including those in F-, K- and T- mechanism training programs.</p><p style="margin-left:0in;">Finally, all DRCs will be required to maintain an <strong>institutional DRC website</strong>, with the Administrative Core taking primary responsibility for its curation and oversight, as well as for ensuring proper and seamless integration of the Center website with the NIDDK Diabetes Research Center program website <a href="http://www.diabetescenters.org/"><u>http://www.diabetescenters.org/</u></a>. </p><h4 style="margin-left:0in;"> </h4><h4 style="margin-left:0in;">Biomedical Resource Cores</h4><p style="margin-left:0in;">DRCs are designed around Biomedical Research Cores that provide shared, specialized technical resources and/or expertise that enhance the efficiency, productivity, and multidisciplinary nature of research performed by Center-affiliated investigators. Cores are intended to facilitate basic and/or clinical research in diabetes, endocrinology and metabolic diseases to accomplish the stated goals and theme(s) of the individual DRC. During the application review, the merit of each core is considered separately and NIDDK may only be able to fund those cores that are rated exceptional or outstanding during peer review. </p><p style="margin-left:0in;">Each Biomedical Research Core should provide state-of-the art services including but not limited to access to specialized equipment for multiple, funded research projects. Examples of current biomedical research cores and the categories they fall into can be found at <a href="https://www.diabetescenters.org/cores">https://www.diabetescenters.org/cores</a>. However, innovation and cores in new areas such as computational biology or bioinformatic applications to diabetes; biomedical engineering, and support of clinical research in diabetes are encouraged. It is expected that the cores proposed address the specific objectives and theme(s) described in the application which is based on the unique requirements of investigators at the applicant institution(s). Emphasis should be placed on services that support and foster interdisciplinary, integrated and translational approaches to research in Diabetes Center topic or thematic areas. Preference will be given to diabetes-related core support services that are not readily available or cost-effective when supplied from commercial sources, and techniques or technologies that may be technically challenging or require specialized expertise, equipment or infrastructure. A justification for the core will be provided in the application. Establishment and continued support of biomedical research cores within a DRC are justified on the basis of significant use by independently funded Center investigators. Thus, usage tables are part of the application. The application should provide a justification for each core that could include: 1) providing added value and access to the resource beyond that provided through fee-for-service; 2) providing a unique resource that would not otherwise be available to individual Center members because it is too costly, too labor-intensive, or too specialized; 3) providing a service more effectively than would be feasible in individual cores, therefore avoiding duplication and lowering cost for Center members; or 4) the service/ instrumentation/ expertise exists only with the participation of multiple centers and their members user fees in proportion to by-in from center to which they belong. The need for core support from the DRC must be well-justified with a broad user base of NIH-funded investigators pursuing research activities in DRC topic areas. The relevance and utilization of the core services by the research base will be emphasized during the review process.</p><p style="margin-left:0in;">If a proposed biomedical research core is an existing institutional or departmental research core, applicants must provide a <strong>strong rationale and compelling justification </strong>addressing the value added for Center members.  In that case it may be helpful to explain if members would still be able to access the core or what their limitations would be if the DRC did not exist. For an exceptional institutional core for which there is a strong and compelling justification, consider the merit of having a faculty liaison or consultant with expertise in both diabetes, endocrinology or metabolism and the technology of that core to assist the members as needed with experimental design and interpretation of data derived from its use of from a diabetes, endocrinology or metabolism perspective.</p><p style="margin-left:0in;">Synergy and avoiding duplication among DRC-supported cores should be a priority to leverage NIDDK-supported resources. Centers are encouraged to interact with the broader research community, serving as resources to support research of importance to NIDDK. Therefore, biomedical research core usage by (1) Members of other DRCs; (2) Members of other NIDDK-funded Centers; and (3) Non-Center members, both locally and nationally, is encouraged when Core capacity allows and institutional policies can be accommodated.</p><p style="margin-left:0in;"><strong>Additional Biomedical Research Core Activities </strong></p><p>Teaching new or complex techniques and methodologies is an important function of a Core. When appropriate, Core staff should provide instruction for investigators, laboratory personnel, and/or fellows to learn, and then become proficient in, technologies that will become part of the repertoire of the user's laboratory. In addition to providing products or services, a Core must ensure appropriate quality control and maintain a record of use. Limited developmental research is also an appropriate function of a Core facility if it is directly related to enhancing the function or usefulness of the Core and is not an undertaking that should more appropriately be funded through other mechanisms. As part of each Core, applicants should provide plans for responding to the changing needs of the Center members.  </p><h4 style="margin-left:0in;">Pilot and Feasibility (P&F) Program</h4><p style="margin-left:0in;">The DRC P&F program provides modest support (typically 1-2 years) for new initiatives or feasibility research studies in Diabetes Center topic areas.  <strong>At least 25% of the overall Center direct costs</strong> should be devoted for support of P&F projects, but additional institutional commitments to increase the pool are welcome. The number and maximum size of the P&F awards, and whether there are different amounts for different types of research grants is entirely up to the applicant, but that should be justified.  The P&F program is particularly directed at <i>early-stage or new investigators </i>to provide them minimal support for collecting required preliminary data to support a grant application for independent research in diabetes/metabolic disease focused area.  P&F study support is not intended for large projects by established investigators that would otherwise be submitted as separate research grant applications or to support or supplement ongoing funded research. It can be used as a strategy to engage an experience researcher from another field (e.g., immunology, neuroscience, artificial intelligence, machine learning etc.) with the goal of applying their novel technology or innovative science to diabetes, endocrinology or metabolic disease research.  </p><p style="margin-left:0in;">The solicitation and review of P&F applications, as well as the review of progress and management of the P&F program reside within each Center. This approach provides each Center with the needed flexibility for effective and efficient management of their P&F program. DRCs are encouraged to partner with other NIDDK-funded Center programs at their Institution and/or regionally to synergize the process of soliciting, reviewing and managing their P&F programs.  DRCs should also participate in contributing to and updating a national reviewer database that is maintained by the NIDDK Diabetes Centers website <a href="https://diabetescenters.org/"><u>https://diabetescenters.org/</u></a></p><h4 style="margin-left:0in;">Additional Opportunities for Resource Cores and Programs</h4><p style="margin-left:0in;">The principal goal of the additional opportunities listed below is to provide regional/national DRC shared biomedical research core services or a regional/national P&F grant program opportunities to support diabetes researchers at institutions that are not currently served by a Diabetes Research Center.  Mechanisms to provide outreach to other diabetes researchers, that are not part of the DRC membership, is a priority for NIDDK. DRCs are encouraged to propose partnerships that establish national or regional biomedical research cores and/or P&F programs with other institutions. The primary goal of such partnerships is to foster scientific collaborations and to provide access to the DRC infrastructure to investigators at these institutions or organizations.</p><p style="margin-left:0in;">Thus, to broaden the scope and reach of the DRC P&F program, a DRC may propose, for example, a <strong>regional or national P&F program that provides grants to other institutions</strong>. In general, NIDDK currently expects DRCs to allow investigators at affiliated hospitals or institutions to participate in the Center P&F program. Expansion of the P&F program to an affiliated institution/hospital is encouraged but is not sufficient to be considered a Regional/National program for purposes of expanding the allowable requested funds. However, applicants may request funds to expand their P&F program to researchers at non-DRC institutions.</p><p style="margin-left:0in;">Alternatively, to broaden the scope and reach of current research core services, a Center may propose to serve a wider scientific community on a geographic or national level through the establishment of a <strong>Regional/National Shared Biomedical ResourceCore </strong>that is located at a different institution. Such a Regional/National Core may not be established with an affiliated hospital of the applicant organization; such an arrangement would be considered an institutional, rather than a regional/national, core for the purposes of this NOFO. If the Center is primarily located at an affiliated hospital, then core(s) based at another affiliated hospital of the same academic institution will not be considered Regional/National Shared Resource Cores. In contrast, with a regional or national core located at a different institution, the Center will service a specific research base that is expanded beyond investigators at the academic institution and/or affiliated hospitals where the Center is primarily located. Support for the expansion of the Center P&F program to investigators at the institution where the Regional/National Shared Resource Core is located is also encouraged.</p><p style="margin-left:0in;"><strong>Additional Opportunity for a National Enrichment Program</strong></p><p style="margin-left:0in;">The Diabetes Research Center may request support for a National Enrichment Program to attract medical students to pursue a career in diabetes research, its complications, and related endocrine and metabolic diseases. NIDDK currently supports short-term (2-3 month) research experiences for medical students through its T32 and T35 institutional training grants. To further enrich these activities in a coordinated fashion across all the NIDDK Diabetes Research Centers, applicants may propose a National Enrichment Program. To enhance their short-term research experiences, medical students may be invited to a 2-day research symposium under the auspices of the Diabetes Research Center National Enrichment Program to present their research results, attend lectures presented by internationally recognized diabetes researchers, learn about future funding opportunities for research training and career development, and to interact with the attending faculty, as well as each other. Furthermore, the National Enrichment Program may propose additional enrichment opportunities for the medical students such as lectures and seminars through webinars, video conferences or other broadly disseminated activities.</p><p style="margin-left:0in;"><strong>The DRC Theme(s) and DRC members</strong></p><p style="margin-left:0in;">The application will describe one or more scientific theme(s) that will be the focus over the period of the grant or provides an overarching description of the work of the center members.  </p><p style="margin-left:0in;">The application will also describe the criteria for being a member of the DRC and how potential future members are nominated, identified or evaluated for inclusion.  It is our position that there is not a one-size best fits all approach to this.  Each DRC may have developed their own approaches for inclusion of and identifying new members that seem to work well for them. As an example, some DRCs only extend membership to faculty members with federal funding, whereas elsewhere faculty seeking funding working in relevant areas may be extended membership.  Some centers have membership policies related to P&F grant recipients.  Alternatively different levels of membership are sometimes proposed.  In other cases a center may  prioritize creating a broader community of those focused on the theme or themes of the DRC.  That may include faculty seeking funding, emeritus faculty, non-faculty (local diabetes or local industry scientists, community members, patient advocates etc.) or trainees.  In other cases, thematic priorities (for example a focus on T1D) may provide a rationale to have a more limited membership.  Similarly, institutional policies related to core charge-backs and other factors including the limited ability to support benefits proposed for members may be a valid consideration.  While the exact strategy for this will reside with the applicants, the rationale for the approach to membership and the process need to be outlined in the proposal and will be part of the evaluation. <strong>If the membership approach includes trainees, non-faculty (e.g., trainees, community or industry representatives) and emeritus faculty, only the biosketches of current funded DRC members who are also institutional faculty on clinical-, research- or tenure- tracks (but not emeritus)  should be included in the application</strong>. Emphasis in the peer review process will be given to the quality of the members research related to the theme(s), potential to benefit from core utilization and potential for collaboration.  As mentioned earlier, at least a core group of members should have consistent and outstanding record of reviewed publications related to the theme or themes, likelihood of collaboration within the center, and other evidence beyond publications of impact on the field.  It is recognized that the community the center aims to ultimately engage may be broader than the members described in the application.</p><p style="margin-left:0in;"><strong>Description of DRC Research Base</strong></p><p style="margin-left:0.0px;">Funding should be described in the following three categories: (1) the <strong>research base</strong> of the proposed DRC members (whose biosketches are included and as reported in dollars from all funding sources ), (2) the <strong>research base from NIDDK</strong> (of the same group), and (3) <strong>all diabetes-related funding to the applicant institution(s) </strong>from any source in the most recent fiscal year (not the multi-year total) including from members and nonmembers. These are described in more detail below along with the rationale.</p><p style="margin-left:0in;">(1) The <strong>research base</strong> from the most recent full fiscal year provides the major support for DRC members. It is the research funding to the proposed DRC members (whose biosketches are included) from all sources [e.g., from government agencies, private foundations or non-profit organizations (dot-orgs) or companies (dot-coms)] except for training and other Center grants for the most recent whole fiscal year. Funds from research grants and research contracts should be included. These peer-reviewed research awards can include government and privately funded research awards to the members, even if the member is in an interdisciplinary field that is nevertheless beneficial to the center.  Since "Facilities and Administration" costs (also known as indirect costs) vary considerably between institutions – <strong>the research base should be calculated using direct costs only</strong>.  While collaboration and synergy between and among training (e.g., T, K, F series awards) and other Centers (e.g., UC2, P, and RC series awards) is strongly encouraged and described within the application, the research base should not include the funding from training or other Center grants. The research base for the DRC, including any affiliated hospitals and proposed partners or partner institutions, <strong>must consist of at least $12 million per year in direct costs of peer-reviewed research projects</strong>. The focus, relevance, interrelationships, quality, productivity, and, to some extent, quantity are all important considerations for the adequacy of

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