Recent Ad Hoc Grant: ZEPIKActive - dCas9 activator for KMT2D function restoration
Funding Amount
$45,132.96
Deadline
Rolling / Open
Grant Type
Foundation
Deadline history & next window
- Cycle
- One-time opportunity
- Tracked since
- April 2026
Source: the cycle recorded on this listing. Confirm dates with the funder.
Overview
ZEPIKActive: Use of dCas9 Activator to Restore Normal KMT2D Function
Award Date: March 2025
This study explores whether dCas9-activated transcription can compensate for KMT2D haploinsufficiency in Kabuki syndrome type 1.
Research Focus
- Kabuki syndrome type 1 (KS1) caused by KMT2D mutations
- Impaired H3K4 methylation and disrupted gene activation
- Use of dCas9 (catalytically inactive Cas9) with transcriptional activator VP60
- Upregulation of wild-type KMT2D allele in zebrafish model of KS1
- Development of novel gene activation-based therapy for KS
Researchers
- Dr. David Geneviève, MD, PhD
- Dr. Farida Djouad, PhD
- Dr. Jean-Christophe Andrau, PhD
- Dr. Kyle Fink, PhD
Contact
Address: P.O. Box 214, Northbrook, IL 60065What Kabuki Syndrome Foundation actually gave
Source: IRS Form 990 filing, 2024
- Grants in 2024
- 3
- Total given
- $239K
- Median grant
- $101K
- Range
- $29K–$109K
- By dollars: Maryland 46%, Massachusetts 42%, Washington 12%. Top recipient cities: Baltimore, MD; Boston, MA; Seattle, WA.
Example grants
Kennedy Krieger Institute · Baltimore, MD
Kabuki syndrome research
$109K
Boston Childrens Hospital · Boston, MA
Kabuki syndrome research
$101K
Seattle Children's Hospital · Seattle, WA
Kabuki syndrome research
$29K
Focus Areas & Funding Uses
Fields of Work
- Science research
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