CTNNB1 Research Grant Program

CTNNB1 Connect and Cure supports several research initiatives a year to advance the understanding and treatment of CTNNB1 Syndrome, and invites proposals on a rolling basis. It may also invite proposals in response to a request for proposals.

Applications are accepted in all areas of research relevant to CTNNB1 Syndrome, with particular interest in projects that will lead to new interventions to alleviate the syndrome's symptoms. The foundation seeks innovative, high-risk and high-reward research in its early stages. The programme is intended to suit junior faculty early in their careers, established investigators in other fields who want to enter CTNNB1 Syndrome research, and rare genetic disease investigators seeking pilot funding in a new area of CTNNB1 research.

Academic, government, non-profit and for-profit research entities may apply. Academic applicants should hold a primary faculty appointment at the level of Instructor or higher, or show that they work under the mentorship of a principal investigator with a faculty appointment. No more than 8% of grant funds may be allocated to indirect costs — overhead or facilities and administrative costs.

Recent awards give a sense of scale: a $50,000 matching grant to Dr Damon Page at Seattle Children's and the University of Washington as the 2025 Rare Epilepsy Partnership Award, funded in partnership with CURE Epilepsy.

Submit a letter of intent first. The foundation's Scientific Advisory Board reviews it alongside an advocate reviewer who assesses how relevant the proposed research is to the CTNNB1 Syndrome community. If the letter of intent is approved, you will be invited to submit a full grant proposal.

Final funding decisions rest on scientific merit, relevance to CTNNB1 Syndrome, funding levels and how well the research suits the foundation's programmatic goals. Keep indirect costs to no more than 8% of the requested funds. Email research@curectnnb1.org with questions or to submit a research proposal; letter of intent and grant guidelines are published on the grant policy page.