CTNNB1 Connect and Cure Grant Program

Geographic Scope: No geographic restrictions mentioned; accepts applications from academic, government, non-profit or for-profit research entities

Program Overview

CCC supports several research initiatives per year to advance the understanding and treatment of CTNNB1 Syndrome. Proposals are invited on a rolling basis and may also be solicited in response to specific Requests for Proposals (RFP).

Focus Areas

• Primary interest: Projects that will lead to new interventions to alleviate symptoms associated with CTNNB1 Syndrome
• Accepted areas: All areas of research relevant to CTNNB1 Syndrome, with particular emphasis on:
  • Developing comprehensive Patient Registry and Natural History Studies
  • Growing mouse models with gene deletions to understand molecular and functional changes
  • Defining molecular and functional changes caused by CTNNB1 allele deletion
  • Developing human-derived neurons to assess molecular changes and treatment effectiveness
  • Partnering with biotech and pharmaceutical companies to advance treatment development

Eligibility

• Applicants: Academic, government, non-profit or for-profit research entities
• Academic researchers: Must have primary faculty appointment at Instructor level or higher, OR be under mentorship of a PI with faculty appointment
• Suitable for: Junior faculty in early career stages, established investigators entering CTNNB1 research field, investigators in rare genetic disease field seeking pilot study funding

Research Type

CCC seeks to support innovative, high-risk/high-reward research in its early stages

Funding Restrictions

• Indirect Costs Cap: No more than 8% of all grant funds may be allocated toward indirect costs (overhead/F&A costs)

Review Process

• Letters of Intent (LOI) reviewed by Scientific Advisory Board (SAB) and an advocate reviewer
• Approved LOIs invited to submit full grant proposal
• Final funding decisions based on: Scientific merit, relevance to CTNNB1 Syndrome, funding levels, and alignment with CCC programmatic goals

Contact Information

• Email: research@curectnnb1.org
• Organization Address: 221 W 9th St Ste 421, Wilmington, DE 19801
• EIN: 83-4541448

Application Process

1. Submission Format: Letters of Intent (LOI) first, followed by full grant proposal if LOI approved
2. LOI Review:
   • Reviewed by Scientific Advisory Board (SAB)
   • Reviewed by an advocate reviewer for relevance to CTNNB1 Syndrome community
3. Full Proposal Submission:
   • Investigators with approved LOI invited to submit full grant proposal
   • Review based on scientific merit, relevance to CTNNB1 Syndrome, funding levels, and programmatic alignment
4. Submission Guidelines:
   • Refer to LOI and grant guidelines (available on website)
   • No more than 8% of grant funds may cover indirect costs
5. Contact for Submissions and Questions:
   • Email: research@curectnnb1.org