Target ALS Foundation Inc is a 501(c)(3) public charity based in New York City dedicated to accelerating research and discovery of effective treatments for amyotrophic lateral sclerosis (ALS). Founded in 2013, the organization operates through its Innovation Ecosystem model, which brings together leading scientists from academia and industry to collaborate on ALS research with unprecedented urgency and efficiency.
Financial Overview
From 2024 IRS Form 990-PF · View filing
Total Assets
$128.9M
-28.6% YoY
Annual Giving
$18.0M
+68.5% YoY
Grant Count
75
+59.6% YoY
Avg Grant Size
$241K
+5.6% YoY
Mission & Focus Areas
Mission: Break down barriers to ALS research to find effective treatments. Target ALS unites academia, the pharma and biotech industry, government, venture capital, nonprofits, and the ALS community to overcome challenges that have historically hindered progress.
Vision: A world where Everyone Lives—where breakthroughs in ALS research lead to effective treatments that give those living with ALS and their families hope and a future they deserve.
Core Values:
- Impatient Optimism: Driven by the urgency of ALS (typically 2-5 years from diagnosis) while remaining steadfastly optimistic that effective treatments are achievable
- Deliberate Disruption: Challenging the status quo by uniting multidisciplinary teams, removing intellectual property restrictions, and providing minimal to no-cost resources globally with no strings attached
- Radical Collaboration: Bringing together diverse voices across researchers, clinicians, industry, and the ALS community
Grantmaking
Target ALS has funded over 750 research grants totaling $80 million invested in ALS research. The organization reports that 58% of research consortia it has funded has led to drug discovery.
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Geographic Focus
Where this funder awards grants
Target ALS funds research primarily in California, New York, and Massachusetts, with a global reach. The organization provides resources and data access worldwide with no strings attached.
Grant Distribution by State
States
Cities
Financial History
Multi-year comparison from IRS filings
As of 2023-2024:
- Total Assets: $128,911,762 (2024)
- Total Revenue: $79.6M (2023); $51,745,776 (2024)
- Total Expenses: $15.9M (2023); $27,108,058 (2024)
- Total Liabilities: $3.05M (2023)
- Total Giving: $18,048,427 (2024)
Major Funding Source: Bloomberg Family Foundation provided $16,000,000 in general support
The organization maintains significant reserves relative to annual spending, positioning it to sustain long-term research initiatives.
| Metric | 2024 | 2023 | 2022 |
|---|---|---|---|
| Total Assets | $128,911,762 | $180,572,961 | $115,562,468 |
| Revenue | $51,745,776 | $79,570,641 | $98,381,069 |
| Expenses | $27,108,058 | $15,859,537 | $9,271,989 |
| Qualifying Distributions | $27,030,939 | $15,856,237 | $9,271,989 |
| Net Investment Income | $3,765,775 | $407,954 | $24,092 |
| Distributable Amount | $3,680,524 | $7,785,698 | $4,423,430 |
Giving Over Time
Total grant dollars and number of grants per year
Grant Insights
How this funder distributes its grants
Top Recipients
Top 10 recipients in 2024
Grant Size Distribution
182 grants across all recorded years
Giving History
Grant recipients and amounts by year
No grants recorded for .
Leadership & Key People
Leadership team and compensation from IRS filings
Founder: Dan Doctoroff (founded Target ALS in 2013)
Staff Contact: Christine Aranyos Prouty (Wire transfer inquiries)
Compensation Overview
From 2024 IRS filing
From 2024 filing
| Name | Title | Hours | Compensation |
|---|---|---|---|
| ALLISON JAFFIN | BOARD MEMBER | 1 | — |
| ANDY BERNDT | BOARD MEMBER | 1 | — |
| CHRIS HENDERSON | BOARD MEMBER | 1 | — |
| MANISH RAISINGHANI | PRESIDENT | 40 | $400,414 |
| KENNETH DEVANEY | TREASURER | 40 | $286,188 |
| DANIEL L DOCTOROFF | CHAIR | 1 | — |
| JOHN DUNLOP | BOARD MEMBER | 1 | — |
| ZACH W HALL | BOARD MEMBER | 1 | — |
| STORY LANDIS | BOARD MEMBER | 1 | — |
| RICHARD HARGEAVES | BOARD MEMBER | 1 | — |
| CAROLE HO | BOARD MEMBER | 1 | — |
| STACIE WENINGER | BOARD MEMBER | 1 | — |
| SARA SHEIKH | BOARD MEMBER | 1 | — |
| ALISA DOCTOROFF | BOARD MEMBER | 1 | — |
| BRAD S KARP | BOARD MEMBER | 1 | — |
Recent News & Activity
Recent developments and announcements
Target ALS continues to expand its grantmaking portfolio with recent announcements including:
2025 In Vivo Target Validation Grantees announced
Announcing the 2025 In Vivo Target Validation Grantees2025 Novel Modalities Consortia Grantees announced
Announcing the 2025 Novel Modalities Consortia GranteesThird-year funding awarded to three groundbreaking projects pushing the frontier of ALS treatment
Target ALS Awards Third-Year Funding to Three Groundbreaking Projects PushingQ1 2026 grants and funding opportunities update released
Q1 2026 Grants & Funding Opportunities Update - Target ALSGrantee NRG Therapeutics advanced NRG5051 into Phase I clinical trial, representing progress toward viable treatments
Target ALS Grantee NRG Therapeutics Advances NRG5051 into ...Contact Information
Address: 244 Madison Avenue #1025, New York, NY 10016
Phone: (332) 333-4140
Website: www.targetals.org
Giving Options: Target ALS accepts one-time donations, monthly gifts, tribute gifts, donor-advised fund recommendations, planned gifts, and corporate sponsorships. The organization also hosts an annual meeting bringing together over 900 global leaders in ALS research and innovation.
Subject Areas
Focus areas based on grantmaking activity
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Data last updated April 2026. Sourced from IRS Form 990-PF filings. Research dossier generated April 2026.
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