Rex Hospital Inc

Duke Energy Foundation

Charlotte, NC

The Duke Energy Foundation funds workforce development, local economic development and recovery, disaster resilience, conservation, and economic opportunity in communities across North Carolina, South Carolina, Florida, Ohio, Kentucky, and Indiana. It reports more than $30 million in annual charitable grants; awards vary widely, with a 2024 median of $25,000, and applications of $20,000 or less are accepted on a rolling basis. Applicants should contact their local Foundation representative before applying.

Wakemed

Raleigh, NC

The mission of wakemed is to improve the health and well-being of our community with outstanding and compassionate care to all.

Stangler Family Foundation

Cary, NC

The Stangler Family Foundation supports charitable organizations working in areas including hunger relief, housing, child and family well-being, conservation, and education, with most 2025 grant funding going to North Carolina, followed by Minnesota. Its 2025 grants ranged from $210 to $20,000, with a median of $1,000. It funds only preselected organizations and does not accept unsolicited requests.

Duke University Health System Inc

Durham, NC

Duke University Health System funds 501(c)(3) organizations working on healthy communities, including housing, healthy food, healthcare access, education, and economic stability. Its 2025 grants ranged from $6,000 to $350,000, with a median of $12,500, and went primarily to North Carolina, with some support in Texas and Tennessee. It accepts unsolicited requests through its Building Healthy Communities application process.

Lonnie & Carol Poole Family Foundation

Raleigh, NC

The foundation supports a range of charitable organizations, including schools and universities, community groups, churches, and service providers; in 2024, grants ranged from $500 to $87,302, with a $5,000 median. Most funding went to North Carolina, with smaller amounts going to other states. It gives only to preselected organizations and does not accept unsolicited requests.

Bell Koonce Burnette Foundation

Raleigh, NC

The Bell Koonce Burnette Foundation funds charitable organizations, including schools, community groups, historic preservation, capital campaigns, endowments, and disaster relief. In 2025, it made 51 grants totaling $345,000, with a median grant of $1,000 and awards ranging from $100 to $200,000; all grant dollars went to North Carolina recipients. It funds only preselected organizations and does not accept unsolicited requests.

Enterprise Holdings Foundation

Saint Louis, MO

The Enterprise Holdings Foundation supports education, environmental stewardship, disaster relief, hunger relief, health, arts, and community needs, with emphasis on organizations connected to Enterprise employees, their families, or established customers. It gives across communities where Enterprise operates; its 2024 median grant was $3,000, though grants ranged widely. Applications are accepted at any time, but the profile does not say whether unsolicited requests are accepted.

Guess Family Foundation

Raleigh, NC

The GUESS FAMILY FOUNDATION funds charitable organizations in health care, social services, disability support, food assistance, and environmental conservation, with grants across multiple states and the largest share going to North Carolina. In 2025, grants ranged from $1,000 to $10,000, with a median of $2,000; it funds only preselected organizations and does not accept unsolicited requests.

United Way of the Greater Triangle Inc

Durham, NC

United Way of the Greater Triangle funds community-driven nonprofit programs addressing poverty and social mobility, including workforce development, housing, food access, health, and youth development. Its 2025 grants had a median award of about $25,000 (range $5,510–$427,548), primarily supporting North Carolina recipients, with a regional focus on Durham, Wake, Orange, and Johnston counties; it describes application processes for specific funds but does not state a general policy on unsolicited requests.

Nancy a Wright Foundation Inc

Chapel Hill, NC

John Rex Endowment

Raleigh, NC

The John Rex Endowment funds efforts to advance racial equity and justice, strengthen organizations, and improve children’s social-emotional health, mainly in Wake County and across North Carolina when children and families there benefit. Its 2024 grants ranged from $50 to $254,100, with a median of $25,000. It accepts requests only through announced funding opportunities, not unsolicited proposals.

John R & Carolyn J Maness Family

Chapel Hill, NC

The John R. & Carolyn J. Maness Family Foundation supports schools, churches, youth development, housing, health care, and the arts, with most 2025 grant dollars going to organizations in North Carolina, Maryland, and Virginia. Its 2025 grants ranged from $500 to $23,000, with a median of $2,000. It does not accept unsolicited requests and funds only preselected organizations.