McKnight Brain Research Foundation
McKnight Brain Research Foundation is a private foundation, based in Orlando, FL. IRS filing data is available from 2021 through 2025. As of 2025, the organization holds $37.4M in total assets. In 2025, it awarded 6 grants totaling $3.1M. Net investment income was $4.1M.
McKnight Brain Research Foundation at a glance
In short: McKnight Brain Research Foundation gave $3.1M across 6 grants in 2025 (avg $519K), mostly in New York. Source: 2025 IRS Form 990-PF.
- Annual giving (2025)
- $3,115,156
- -29.9% vs 2024
- Grants made (2025)
- 6
- -25.0% vs 2024
- Average grant
- $519,193
- -6.5% vs 2024
- Median grant
- $210,044
- Total assets
- $37,351,567
- -5.2% vs 2024
- Primary geography
- New York (50% of itemized 2025 grant dollars)
- Latest 990 filing
- Form 990-PF, 2025 View filing
Data from IRS Form 990-PF, 2025; updated September 2026.
Who McKnight Brain Research Foundation funds
How this funder distributes its grants
Top Recipients
Top 6 recipients in 2025
The largest 2025 recipient was American Federation for Aging Research ($1.5M). Together the top 6 received $3.1M.
Grant Size Distribution
34 grants across all recorded years
The most common grant size was under $50K: 10 grants of 34 (29%).
Geographic Focus
Where this funder awards grants
Grant Distribution by State
Share of 2025 grant dollars across all 6 itemized grants.
Cities
How McKnight Brain Research Foundation gives
- Giving grew 48% from 2022 to 2025. Method
- In 2025 it paid out 148% of its IRS minimum distribution (the 5% rule). Method
From the foundation's IRS Form 990-PF filings. Methodology.
Giving History
Giving Over Time
Total grant dollars and number of grants per year
From 2021 to 2025, annual grant giving ranged from $1.6M (2021) to $4.4M (2024). In 2025 it made 6 grants totaling $3.1M.
Grants by year
Grant recipients and amounts by year
| Recipient | Purpose | Amount |
|---|---|---|
| American Federation for Aging Research New York, NY | Funding of research | $1,543,700 |
| Foundation for the NIH North Bethesda, MD | Funding of research | $1,000,000 |
| American Brain Foundation Minneapolis, MN | Funding scholarship in cognitive aging and memory loss | $247,500 |
| University of Miami Coral Gables, FL | Funding of research | $172,588 |
| University of Alabama Birmingham Birmingham, AL | Funding of the Evelyn F. McKnight Brain Institute at UAB | $94,270 |
| University of Arizona Tucson, AZ | Funding of the Evelyn F. McKnight Brain Institute at the University of Arizona | $57,098 |
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Financial History
Multi-year comparison from IRS filings
| Filing year | Total Assets | Revenue | Expenses | Grants paid | Grants | Qualifying Distributions | Net Investment Income | Distributable Amount |
|---|---|---|---|---|---|---|---|---|
| 2025 | $37,351,567 | $3,138,894 | $5,180,121 | $3,115,156 | 6 | $4,416,061 | $4,093,177 | $2,988,893 |
| 2024 | $39,392,794 | $2,866,976 | $6,071,805 | $4,443,873 | 8 | $5,523,135 | $3,436,233 | $2,828,126 |
| 2023 | $42,597,623 | $731,936 | $2,967,372 | $1,681,922 | 5 | $2,424,751 | $1,879,806 | $2,774,744 |
| 2022 | $44,833,059 | $5,557,490 | $3,157,133 | $2,097,815 | 8 | $2,703,592 | $5,591,580 | $3,015,394 |
| 2021 | $42,432,702 | $9,753,717 | $2,523,177 | $1,591,958 | 7 | — | $9,138,969 | $2,728,732 |
Under IRS private-foundation payout rules, McKnight Brain Research Foundation reported a distributable amount of $3.0M for 2025 — the minimum it must pay out in qualifying distributions.
Leadership & Key People
Officers and directors from IRS filings
McKnight Brain Research Foundation is led by Alice Luo Clayton, CEO on the 2025 filing; all 13 officers listed in 2025 are compensated.
Officers on the 2025 filing
Alice Luo Clayton
CEO
New on the 2025 filing
40 hrs/week
$54K (2025)
Amy Porter
Interim Executive Director
Executive Director → Interim Executive Director, 2025
On filings since 2021
20 hrs/week
$118K (2021) → $120K (2025)
Angelika Schlanger
Executive Director
On filings since 2023
40 hrs/week
$192K (2023) → $36K (2025)
Allison Brashear
Trustee
On filings since 2021
6 hrs/week
$30K (2021) → $50K (2025)
Madhav Thambisetty
Trustee
On filings since 2021
6 hrs/week
$3K (2023) → $170K (2025)
Michael Dockery
Trustee
On filings since 2021
6 hrs/week
$40K (2021) → $50K (2025)
Patricia Boyle
Trustee
On filings since 2021
6 hrs/week
$30K (2021) → $50K (2025)
Susan Pekarkse
Trustee
On filings since 2021
6 hrs/week
$40K (2021) → $50K (2025)
Truist Bank
Trustee
On filings since 2021
15 hrs/week
$172K (2021) → $188K (2025)
John Brady
Trustee
On filings since 2022
6 hrs/week
$20K (2022) → $50K (2025)
Roy Hamilton
Trustee
On filings since 2024
6 hrs/week
$40K (2024) → $50K (2025)
Sharon Brangman
Trustee
On filings since 2024
6 hrs/week
$40K (2024) → $50K (2025)
J Lee Dockery
Trustee Emeritus
On filings since 2021
6 hrs/week
$40K (2021) → $50K (2025)
Former officers (3)
- Former: Richard Isaacson (2021–2023) — Trustee
- Former: Robert Wah (2021–2022) — Trustee
- Former: Gene G Ryerson (2021) — Trustee · Filing note: Ended 43021
Data from IRS Form 990 filings, 2021–2025. "On filings since" is the earliest filing we hold that lists the person; hours are average hours per week as reported.
Compensation Overview
From 2025 IRS filing
The highest reported compensation on the 2025 filing was $188K, to Truist Bank (Trustee). 13 officers or directors reported compensation on that filing.
Frequently asked questions about McKnight Brain Research Foundation
How much does McKnight Brain Research Foundation give each year?
McKnight Brain Research Foundation gave $3.1M across 6 grants in 2025, according to its 2025 IRS Form 990-PF. In 2024 it gave $4.4M across 8 grants.
What is McKnight Brain Research Foundation's typical grant size?
McKnight Brain Research Foundation's median grant in 2025 was $210,044, and its average grant was $519,193, across 6 grants on its 2025 IRS Form 990-PF.
Where does McKnight Brain Research Foundation give grants?
McKnight Brain Research Foundation gives mostly in New York: 50% of the grant dollars itemized on its 2025 IRS Form 990-PF went to recipients there. The next largest states were Maryland (32%) and Minnesota (8%).
Does McKnight Brain Research Foundation give general operating support?
Not in 2025: none of the 6 grants with a stated purpose on McKnight Brain Research Foundation's 2025 IRS Form 990-PF were described as general or operating support. Recurring purposes include "Funding of research" (3 grants).
Who are McKnight Brain Research Foundation's largest grantees?
McKnight Brain Research Foundation's largest 2025 grantees include American Federation for Aging Research ($1,543,700), Foundation for the NIH ($1,000,000) and American Brain Foundation ($247,500), according to its 2025 IRS Form 990-PF. Together they received 90% of its itemized 2025 grant dollars.
How large is McKnight Brain Research Foundation?
McKnight Brain Research Foundation reported $37.4M in total assets on its 2025 IRS Form 990-PF. It paid out $4.4M in qualifying distributions that year, against a required minimum of $3.0M (roughly 5% of its investment assets).
What is McKnight Brain Research Foundation's EIN?
McKnight Brain Research Foundation's EIN (Employer Identification Number) is 65-6301255. IRS Form 990 filing data is available on this page for 2021–2025.
Data last updated September 2026. Sourced from IRS Form 990-PF filings.
Data update history
(6)
When this profile's IRS filing data changed on Grantable
- Updated Form 990-PF for fiscal year 2021 (received by the IRS May 2, 2022)
- Updated Form 990-PF for fiscal year 2022 (received by the IRS May 11, 2023)
- Updated Form 990-PF for fiscal year 2023 (received by the IRS May 14, 2024)
- Updated Form 990-PF for fiscal year 2024 (received by the IRS May 3, 2025)
- Added Form 990-PF for fiscal year 2025 (received by the IRS May 14, 2026)
- IRS filings on file for fiscal years 2021–2024
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