Howard Hughes Medical Institute
The Howard Hughes Medical Institute (HHMI) is a private biomedical research institution based in Chevy Chase, Maryland, and listed as a public charity. Founded in 1953, it supports scientists through long-term programs and also supports science education and public engagement.
Howard Hughes Medical Institute at a glance
In short: Howard Hughes Medical Institute gave $8.8M across 31 grants in 2025 (avg $285K), top state California. 45% of 2025 grantees were new. Source: 2025 IRS Form 990.
- Annual giving (2025)
- $8,823,841
- -82.9% vs 2024
- Grants made (2025)
- 31
- -50.0% vs 2024
- Average grant
- $284,640
- -65.8% vs 2024
- Median grant
- $20,000
- Total assets
- $29,497,763,012
- +8.1% vs 2024
- New grantees (estimate)
- 45% first-time grantees (13 of 29, 2025)
- Primary geography
- California (41% of itemized 2025 grant dollars)
- Latest 990 filing
- Form 990, 2025 View filing
Data from IRS Form 990, 2025; updated October 2026. New grantees are estimated by matching recipient names across years (methodology).
How to apply to Howard Hughes Medical Institute
- Accepts unsolicited proposals
- No
- Invitation Only
-
HHMI does not accept unsolicited requests. Applicants should review the eligibility criteria and application process for the specific competition; most competitions have a formal invitation and review process.
- Contact
Mailing address: 4000 Jones Bridge Road, Chevy Chase, MD 20815-6789
Phone: (301) 215-8500
Website: https://hhmi.org
Application details from Grantable's research on the foundation's public materials; confirm on its website before applying.
Open Grants
5 open opportunities from Howard Hughes Medical Institute
Freeman Hrabowski Scholars Program
Howard Hughes Medical Institute
Amount
Varies
Deadline
Deadline not published
Gilliam Fellows Program
Howard Hughes Medical Institute
Amount
Varies
Deadline
Deadline not published
Hanna H. Gray Fellows Program: Faculty Phase Grant
Howard Hughes Medical Institute
Amount
Up to US $1,080,000
Deadline
Deadline not published
Who Howard Hughes Medical Institute funds
How this funder distributes its grants
Top Recipients
Top 10 recipients in 2025
The largest 2025 recipient was University of California San Francisco ($3.1M). Together the top 10 received $8.5M.
Grant Size Distribution
521 grants across all recorded years
The most common grant size was under $50K: 208 grants of 521 (40%).
Geographic Focus
Where this funder awards grants
HHMI’s scientific research programs are open to researchers at institutions across the United States. In the 2025 itemized grants, recipient states accounting for the largest shares of grant dollars were California (41%), Massachusetts (25%), Connecticut (15%), Virginia (11%), and North Carolina (6%).
Grant Distribution by State
Share of 2025 grant dollars across all 31 itemized grants.
States
Cities
Is Howard Hughes Medical Institute open to new grantees?
45%
first-time grantees, 2025
In 2025, 13 of 29 grantees (45%) were first-time recipients. First grants averaged $47K; repeat grants $513K. How we count
Medians: $20K first-time, $25K repeat.
Estimate from itemized grant lists in IRS Form 990 filings (2019–2025). Recipient names are matched across years, so a renamed or misspelled grantee can look new; grants to individuals are left out. Methodology.
Giving History
Giving Over Time
Total grant dollars and number of grants per year
From 2019 to 2025, annual grant giving ranged from $8.8M (2025) to $103.8M (2023). In 2025 it made 31 grants totaling $8.8M.
Grants by year
Grant recipients and amounts by year
| Recipient | Purpose | Amount |
|---|---|---|
| University of California San Francisco San Francisco, CA | Medical Research | $3,062,953 |
| Harvard University Cambridge, MA | Medical Research | $2,113,215 |
| Yale University New Haven, CT | Medical Research | $1,286,366 |
| Loudoun County Public Schools Ashburn, VA | Support of K-12 Science Education Activities | $1,000,000 |
| Stanford University Redwood City, CA | Medical Research | $502,742 |
| North Carolina Central University Durham, NC | Science Education Alliance | $370,465 |
| Helen Hay Whitney Foundation New York, NY | Medical Research | $73,500 |
| University of Oklahoma Norman, OK | Biointeractive | $39,600 |
| New Mexico State University Las Cruces, NM | Driving Change | $25,000 |
| North Carolina a & T State University Greensboro, NC | Driving Change | $25,000 |
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Financial History
Multi-year comparison from IRS filings
| Filing year | Total Assets | Revenue | Expenses | Grants paid | Grants | Net Investment Income |
|---|---|---|---|---|---|---|
| 2025 | $29,497,763,012 | $2,004,784,057 | $1,178,202,544 | $8,823,841 | 31 | $1,966,414,132 |
| 2024 | $27,296,895,597 | $1,760,221,928 | $1,152,447,870 | $51,583,110 | 62 | $1,737,313,649 |
| 2023 | $25,892,499,538 | $749,022,788 | $1,147,090,579 | $103,771,412 | 180 | $718,984,759 |
| 2022 | $25,877,392,654 | $2,117,477,557 | $986,289,955 | $21,505,266 | 54 | $2,087,454,899 |
| 2021 | $29,343,107,763 | $2,096,794,078 | $954,764,083 | $26,819,790 | 194 | $2,072,096,518 |
| 2020 | $23,840,455,852 | $1,467,289,681 | $947,377,660 | $41,421,583 | 81 | $1,451,456,638 |
| 2019 | $22,544,411,510 | $1,411,381,183 | $1,081,673,510 | $24,941,559 | 122 | $1,307,204,710 |
Research compiled by Grantable AI from public sources. Last updated October 2026.
Mission & Focus Areas
HHMI’s stated mission is to promote human knowledge through discovery research and science education, principally in basic biomedical sciences, and to disseminate and apply that knowledge for humanity’s benefit.
Its research activities include the Investigator Program and Janelia Research Campus, alongside programs for scientists at different career stages. HHMI describes its approach as “people, not projects.” Investigators are HHMI employees who retain academic appointments and laboratories at their home institutions; they receive an initial seven-year appointment, renewable following successful review. HHMI also describes its work in science education, fellowships, and media, including the Gilliam Fellows, Hanna H. Gray Fellows, and Freeman Hrabowski Scholars programs.
The 2025 filing lists support for universities and other organizations. Examples include medical research grants to the University of California, an individual recipient, Harvard University, Yale University, and Stanford University. Other listed purposes include K–12 science education activities, a Science Education Alliance, BioInteractive, and the Driving Change initiative. Among the grantees described in their own statements, the American Society for Cell Biology says it leads a global scientific community focused on the cell, and the Whitehead Institute for Biomedical Research says it advances research in genetics and genomics.
Grantmaking
In filing year 2025, HHMI reported 31 itemized grants totaling $8,823,841. The grants ranged from $10,000 to $3,062,953, with a median of $20,000. The largest listed awards were $3,062,953 to the University of California, an individual recipient, for medical research; $2,113,215 to Harvard University for medical research; $1,286,366 to Yale University for medical research; and $1,000,000 to Loudoun County Public Schools for K–12 science education activities.
HHMI’s website describes competitions for programs including Investigators, Freeman Hrabowski Scholars, Hanna Gray Fellows, and Gilliam Fellows. It says scientific programs have specific objectives and eligibility criteria, and that most competitions use formal invitation and review processes. The Gilliam program page in the supplied program information says it is not currently accepting applications. The Hanna H. Gray Fellows program is listed as active; the supplied description says it supports early-career researchers and gives eligibility information including a PhD or MD, at least 75% research effort, and no more than 24 months of postdoctoral experience. Awards to program participants are distinct from HHMI’s grants to outside organizations.
Leadership & Key People
Leadership team and compensation from IRS filings
The 2025 filing lists Clayton S. Rose as trustee and chair; Charlene Barshefsky as trustee and chair of the Nominating and Governance Committee; David Julius as trustee and chair of the Research Committee; Debora L. Spar as trustee and chair of the Audit and Compensation Committee; and Fred R. Lummis as trustee and chair of the Finance Committee. It also lists Alison F. Richard, Edith Heard, Jay Jacobs, Joseph L. Goldstein, and Kurt L. Schmoke as trustees.
HHMI’s website says its board of trustees meets four times a year and carries out governance through five standing committees.
Howard Hughes Medical Institute is led by Erin K. O'Shea PhD, President on every filing since 2019; all 34 officers listed in 2025 are compensated.
Officers on the 2025 filing
Erin K. O'Shea PhD
President
On filings since 2019
40 hrs/week
$1.2M (2019) → $1.7M (2025)
Gerald M. Rubin PhD
Senior Group Leader, Former Vice President, Executive Director & Jrc
Vice President, Executive Director & Janelia Res Campus → Vice President, Executive Director, Jrc & Senior Group Leader, 2020
Vice President, Executive Director, Jrc & Senior Group Leader → Senior Group Leader, Former Vice President, Executive Director & Jrc, 2021
On filings since 2019
40 hrs/week
$811K (2019) → $599K (2025)
Sean B. Carroll PhD
Investigator, Former Vice President Sci. & Executive Director Media Group
Vice President for Science & Educational Media Group → Investigator, Former Vice President Sci. & Ed.media Group, 2024
Investigator, Former Vice President Sci. & Ed.media Group → Investigator, Former Vice President Sci. & Executive Director Media Group, 2025
On filings since 2019
40 hrs/week
$739K (2019) → $594K (2025)
Ronald Vale PhD
Senior Group Leader, Former Vice President, Executive Director & Jrc
Vice President, Executive Director & Janelia Research Campus → Senior Group Leader, Former Vice President, Executive Director & Jrc, 2025
On filings since 2020
40 hrs/week
$513K (2020) → $770K (2025)
Nelson Spruston PhD
Vice President, Executive Director & Janelia Research Campus
On filings since 2024
40 hrs/week
$668K (2024) → $644K (2025)
Seth Grossman Esq.
Vice President, Chief Operating Officer & Senior Advisor to the President
On filings since 2024
40 hrs/week
$541K (2025)
Charlene Barshefsky Esq.
Trustee, Chair Nom & Gov Committee
Trustee → Trustee, Chair Nom & Gov Committee, 2021
On filings since 2019
4 hrs/week
$40K (2019) → $88K (2025)
Clayton S. Rose PhD
Trustee & Chair
Trustee, Chair Audit & Comptroller → Trustee, Chair, Chair Audit & Comptroller, 2020
Trustee, Chair, Chair Audit & Comptroller → Trustee & Chair, 2021
On filings since 2019
6 hrs/week
$50K (2019) → $100K (2025)
Debora L. Spar PhD
Trustee, Chair Audit & Comptroller
Trustee → Trustee, Chair Audit & Comptroller, 2020
On filings since 2019
4 hrs/week
$40K (2019) → $70K (2025)
Fred R. Lummis
Trustee & Chair Finance Committee
On filings since 2019
4 hrs/week
$50K (2019) → $70K (2025)
David Julius PhD
Trustee & Chair Research Committee
Trustee → Trustee & Chair Research Committee, 2025
On filings since 2021
3 hrs/week
$54K (2022) → $60K (2025)
Risa Lavizzo-Mourey MD MBA
Trustee & Chair Education Committee
Trustee → Trustee & Chair Education Committee, 2025
On filings since 2021
3 hrs/week
$51K (2022) → $60K (2025)
Glen Zwicker
Managing Director & Head of Investment Operations
Managing Director & Head of Investment Ops → Managing Director & Head of Investment Operations, 2024
On filings since 2020
40 hrs/week
$695K (2020) → $1M (2025)
Mark Sproles
Managing Director & Private Markets
On filings since 2023
40 hrs/week
$951K (2023) → $1.2M (2025)
Karen Eifler
Managing Director & Public Markets
On filings since 2024
40 hrs/week
$989K (2024) → $1.2M (2025)
Alison F. Richard PhD
Trustee
Trustee & Chair Education Committee → Trustee, 2025
On filings since 2019
3 hrs/week
$50K (2019) → $70K (2025)
Joseph L. Goldstein MD
Trustee
Trustee & Research Committee → Trustee & Chair Research Committee, 2022
Trustee & Chair Research Committee → Trustee, 2025
On filings since 2019
3 hrs/week
$50K (2019) → $70K (2025)
Kurt L. Schmoke Esq.
Trustee
Trustee & Chair → Trustee, 2021
On filings since 2019
2 hrs/week
$60K (2019) → $50K (2025)
Margaret D. Tutwiler
Trustee
Trustee From → Trustee, 2020
On filings since 2019
2 hrs/week
$33K (2020) → $60K (2025)
Paul M. Nurse PhD
Trustee
On filings since 2019
2 hrs/week
$40K (2019) → $60K (2025)
Natasha Neises
Senior Director, Financial Planning & Analysis
On filings since 2023
40 hrs/week
$268K (2023) → $295K (2025)
Edith Heard PhD
Trustee & Advisory Board Member
New on the 2025 filing
2 hrs/week
$13K (2025)
Jay Jacobs
Trustee
New on the 2025 filing
2 hrs/week
$15K (2025)
Kristian Greene
Director, Treasury Operations & Assistant Treasurer
New on the 2025 filing
40 hrs/week
$176K (2025)
Bodo Stern PhD
Chief of Strategic Initiatives
On filings since 2019
40 hrs/week
$353K (2019) → $447K (2025)
David E. Clapham PhD
Senior Group Leader, Former Vice President & Chief Scientific Officer
Vice President, Chief Scientific Officer & Senior Group Leader → Senior Group Leader, Former Vice President & Chief Science Officer, 2023
Senior Group Leader, Former Vice President & Chief Science Officer → Senior Group Leader, Former Vice President & Chief Scientific Officer, 2024
On filings since 2019
40 hrs/week
$896K (2019) → $590K (2025)
Heidi E. Henning Esq.
Vice President, General Counsel & Secretary
On filings since 2019
40 hrs/week
$660K (2019) → $832K (2025)
Richard Axel MD
Investigator
On filings since 2019
40 hrs/week
$581K (2019) → $807K (2025)
Jeremy Compton
Controller
Associate Controller & Assistant Treasurer → Associate Controller, Controller & Assistant Treasurer, 2024
Associate Controller, Controller & Assistant Treasurer → Controller, 2025
On filings since 2020
40 hrs/week
$171K (2020) → $265K (2025)
Donald Koch
Vice President & Chief Investment Officer
On filings since 2021
40 hrs/week
$1.2M (2021) → $1.9M (2025)
Leslie B. Vosshall PhD
Vice President & Chief Scientific Officer
Investigator, Vice President & Chief Scientific Officer → Vice President & Chief Scientific Officer, 2023
On filings since 2022
40 hrs/week
$713K (2022) → $772K (2025)
Lynne Lochte
Chief Financial Officer & Treasurer
Deputy Chief Financial Officer & Assistant Treasurer → Chief Financial Officer & Treasurer, 2023
On filings since 2022
40 hrs/week
$85K (2023) → $481K (2025)
Blanton Tolbert PhD
Vice President Science Leadership, Culture & Lab Head
Vice President of Science Leadership & Culture → Vice President Science Leadership & Culture, 2024
Vice President Science Leadership & Culture → Vice President Science Leadership, Culture & Lab Head, 2025
On filings since 2023
40 hrs/week
$119K (2023) → $778K (2025)
Kristina Heiberger Esq.
Deputy General Counsel & Assistant Secretary
On filings since 2023
40 hrs/week
$286K (2023) → $425K (2025)
Former officers (22)
- Former: Dennis McKearin PhD (2019–2024) — Senior Scientific Officer & Former Vice President of Operations
- Former: Richard A. Pender (2019–2024) — Managing Director & Public Markets
- Former: Daniel A. Cronin PhD (2020–2024) — Vice President, Chief Financial & Operating Officer
- Former: Justin Galen (2024) — Managing Director & Private Markets
- Former: Gregory Deninno (2019–2023) — Managing Director & Private Markets
- Former: Monique L. Marcus (2019–2023) — Controller
- Former: Susan S. Plotnick (2019–2023) — Director of Finance & Assistant Treasurer
- Former: Ann K. Batlle Esq. (2022–2023) — Deputy General Counsel & Assistant Secretary
- Former: Eric R. Kandel MD (2019–2022) — Investigator
- Former: Landis Zimmerman (2019–2022) — Vice President & Chief Investment Officer
- Former: Lauren T. Spiliotes Esq. (2019–2022) — Deputy General Counsel & Assistant Secretary
- Former: Robert J. Kolyer Jr. (2019–2022) — Managing Director & Diversifying Assets
- Former: Anne M. Tatlock (2019–2021) — Trustee, Chair Nom & Gov Committee
- Former: James A. Baker III Esq. (2019–2021) — Trustee
- Former: John Palmisano (2019–2021) — Chief of Business Solutions & Former Vice President for Information Technology
- Former: Robert Tjian PhD (2019–2021) — Investigator & Former President
- Former: Stephen Jasko (2019–2021) — Former Chief Financial Officer & Treasurer
- Former: Randy W. Schekman PhD (2020–2021) — Investigator
- Former: Tom Cech PhD (2020–2021) — Investigator
- Former: Frances M. Phelan (2019) — Chief of People & Culture
- Former: Stephen M. Kitsoulis (2019) — Man Director - Fixed Income Retired
- Former: Thomas R. Cech PhD (2019) — Investigator
Data from IRS Form 990 filings, 2019–2025. "On filings since" is the earliest filing we hold that lists the person; hours are average hours per week as reported.
Compensation Overview
From 2025 IRS filing
The highest reported compensation on the 2025 filing was $1.9M, to Donald Koch (VP & Chief Investment Officer). 34 officers or directors reported compensation on that filing.
Frequently asked questions about Howard Hughes Medical Institute
How much does Howard Hughes Medical Institute give each year?
Howard Hughes Medical Institute gave $8.8M across 31 grants in 2025, according to its 2025 IRS Form 990. In 2024 it gave $51.6M across 62 grants.
What is Howard Hughes Medical Institute's typical grant size?
Howard Hughes Medical Institute's median grant in 2025 was $20,000, and its average grant was $284,640, across 31 grants on its 2025 IRS Form 990. Organizations receiving their first grant from Howard Hughes Medical Institute that year got $47K on average.
Where does Howard Hughes Medical Institute give grants?
Howard Hughes Medical Institute's top state is California, with 41% of the grant dollars itemized on its 2025 IRS Form 990. The next largest states were Massachusetts (25%) and Connecticut (15%). The most frequent recipient cities were Cambridge, MA (4 grants), Greensboro, NC (3 grants) and Norman, OK (2 grants).
Does Howard Hughes Medical Institute give general operating support?
Not in 2025: none of the 31 grants with a stated purpose on Howard Hughes Medical Institute's 2025 IRS Form 990 were described as general or operating support. Recurring purposes include "Medical Research" (17 grants), "Science Education Alliance" (5 grants) and "Driving Change" (4 grants).
Who are Howard Hughes Medical Institute's largest grantees?
Howard Hughes Medical Institute's largest 2025 grantees include University of California San Francisco ($3,062,953), Harvard University ($2,113,215) and Yale University ($1,286,366), according to its 2025 IRS Form 990. Together they received 73% of its itemized 2025 grant dollars.
How large is Howard Hughes Medical Institute?
Howard Hughes Medical Institute reported $29.5B in total assets on its 2025 IRS Form 990. Its revenue that year was $2.0B.
What does Howard Hughes Medical Institute fund?
HHMI’s stated mission is to promote human knowledge through discovery research and science education, principally in basic biomedical sciences, and to disseminate and apply that knowledge for humanity’s benefit. See mission & focus areas ↑
How do I apply for a grant from Howard Hughes Medical Institute?
HHMI does not accept unsolicited requests. Eligibility and process details are in the grantmaking section of this profile. See how to apply ↑
What is Howard Hughes Medical Institute's EIN?
Howard Hughes Medical Institute's EIN (Employer Identification Number) is 59-0735717. IRS Form 990 filing data is available on this page for 2019–2025.
Does Howard Hughes Medical Institute accept unsolicited proposals?
No, according to Grantable's research on the foundation's published guidelines. See how to apply ↑
Data last updated October 2026. Sourced from IRS Form 990 filings. Research dossier generated October 2026.
Data update history
(7)
When this profile's IRS filing data changed on Grantable
- Updated Form 990 for fiscal year 2024 (received by the IRS February 14, 2025)
- Updated Form 990 for fiscal year 2025 (received by the IRS February 10, 2026)
- Updated Form 990 for fiscal year 2019 (received by the IRS March 2, 2020)
- Updated Form 990 for fiscal year 2020 (received by the IRS March 18, 2021)
- Updated Form 990 for fiscal year 2021 (received by the IRS February 8, 2022)
- Updated Form 990 for fiscal year 2022 (received by the IRS February 22, 2023)
- Updated Form 990 for fiscal year 2023 (received by the IRS February 21, 2024)
Explore Open Grants
Browse active grant opportunities in Howard Hughes Medical Institute's focus areas in our free grants database
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Cite this profile
Grantable. (2026). Howard Hughes Medical Institute funder profile. GrantGraph. Retrieved October 11, 2026, from https://grantable.co/funders/howard-hughes-medical-institute-morg_404f91b395864122bfbd78f5ba73dfc5
BibTeX
@misc{grantable_590735717_2026,
author = {{Grantable}},
title = {{Howard Hughes Medical Institute funder profile}},
howpublished = {GrantGraph},
year = {2026},
url = {https://grantable.co/funders/howard-hughes-medical-institute-morg_404f91b395864122bfbd78f5ba73dfc5},
note = {Accessed 2026-10-11. Data licensed CC BY 4.0}
}The figures on this page are open data under CC BY 4.0: reuse them with credit to Grantable and a link. Download the data.
Figures come from Howard Hughes Medical Institute's IRS filings (methodology). AI-written summaries, news items and logos are not covered by the open licence. Spot an error? Email hello@grantable.co.
Howard Hughes Medical Institute down — hundreds of funders to go?