Critical Path Institute
Critical Path Institute (C-Path) is a public charity based in Tucson, Arizona. It leads public-private collaborations to improve drug development, including by developing tools and approaches that support research, clinical trials, and regulatory decision-making.
Critical Path Institute at a glance
In short: Critical Path Institute gave $3.8M across 17 grants in 2025 (avg $221K), top state Massachusetts. 71% of 2025 grantees were new. Source: 2025 IRS Form 990.
- Annual giving (2025)
- $3,758,536
- -21.6% vs 2024
- Grants made (2025)
- 17
- +21.4% vs 2024
- Average grant
- $221,090
- -35.5% vs 2024
- Median grant
- $127,093
- Total assets
- $38,361,666
- +22.6% vs 2024
- New grantees (estimate)
- 71% first-time grantees (12 of 17, 2025; small sample)
- Primary geography
- Massachusetts (35% of itemized 2025 grant dollars)
- Latest 990 filing
- Form 990, 2025 View filing
Data from IRS Form 990, 2025; updated October 2026. New grantees are estimated by matching recipient names across years (methodology).
How to apply to Critical Path Institute
- How to Apply
-
The TRxA website describes awards for academic researchers who apply and are selected. It provides eligibility, project-scope, and funding-level information, and says funded institutions negotiate a project agreement with the program.
- Contact
Mailing address: 1840 E River Road 100, Tucson, AZ 85718
Phone: (520) 547-3440
Website: https://c-path.org
Application details from Grantable's research on the foundation's public materials; confirm on its website before applying.
Open Grants
2 open opportunities from Critical Path Institute
Who Critical Path Institute funds
How this funder distributes its grants
Top Recipients
Top 10 recipients in 2025
The largest 2025 recipient was National Organization for Rare Disorders ($1.3M). Together the top 10 received $3.2M.
Grant Size Distribution
65 grants across all recorded years
The most common grant size was in the $100–250K range: 24 grants of 65 (37%).
Geographic Focus
Where this funder awards grants
C-Path’s TRxA FAQ says funding is available to eligible faculty and projects at academic or nonprofit organizations anywhere in the world. In 2025, the largest shares of reported grant dollars went to recipients in Massachusetts (35%), California (12%), Illinois (10%), North Carolina (9%), and Pennsylvania (6%).
Grant Distribution by State
Share of 2025 grant dollars across all 17 itemized grants.
States
Cities
Is Critical Path Institute open to new grantees?
71%
first-time grantees, 2025
In 2025, 12 of 17 grantees (71%) were first-time recipients. With only 17 grantees, that is a small sample: one grantee more or less moves the share by about 6 points. First grants averaged $239K; repeat grants $179K. How we count
Medians: $119K first-time, $145K repeat.
- 29% of 2025 grantees were also funded in 2024. Method
- Giving held roughly steady from 2022 to 2025 (−4%). Method
Estimate from itemized grant lists in IRS Form 990 filings (2019–2025). Recipient names are matched across years, so a renamed or misspelled grantee can look new; grants to individuals are left out. Methodology.
Giving History
Giving Over Time
Total grant dollars and number of grants per year
From 2019 to 2025, annual grant giving ranged from $1.9M (2019) to $4.8M (2024). In 2025 it made 17 grants totaling $3.8M.
Grants by year
Grant recipients and amounts by year
| Recipient | Purpose | Amount |
|---|---|---|
| National Organization for Rare Disorders Quincy, MA | Subaward | $1,319,385 |
| Northwestern University Evanston, IL | Subaward | $381,946 |
| University of California San Francisco, CA | Subaward | $347,500 |
| Seattle Children's Hospital Seattle, WA | Subaward | $234,728 |
| Wake Forest University Charlotte, NC | Subaward | $215,717 |
| Yale University New Haven, CT | Subaward | $172,778 |
| University of Pittsburgh Pittsburgh, PA | Subaward | $145,000 |
| Washington University St. Louis, MO | Subaward | $140,000 |
| University Hospital Cleveland Medical Ctr Cleveland, OH | Subaward | $127,093 |
| Bioagilytix Labs Durham, NC | Subaward | $111,767 |
Ready to take the next step with Critical Path Institute?
Financial History
Multi-year comparison from IRS filings
| Filing year | Total Assets | Revenue | Expenses | Grants paid | Grants | Net Investment Income |
|---|---|---|---|---|---|---|
| 2025 | $38,361,666 | $46,783,745 | $40,232,360 | $3,758,536 | 17 | $934,975 |
| 2024 | $31,286,582 | $42,610,862 | $38,344,617 | $4,796,570 | 14 | $949,583 |
| 2023 | $26,726,645 | $35,267,282 | $32,008,378 | $4,116,598 | 12 | $403,834 |
| 2022 | $19,962,086 | $31,176,116 | $29,600,280 | $3,914,930 | 12 | $6,633 |
| 2021 | $18,494,765 | $24,427,097 | $23,005,505 | $2,981,277 | 10 | $5,817 |
| 2020 | $16,657,850 | $18,464,314 | $17,552,600 | $2,499,466 | 9 | $156,753 |
| 2019 | $17,507,463 | $16,797,670 | $15,372,966 | $1,911,646 | 9 | $215,046 |
Research compiled by Grantable AI from public sources. Last updated October 2026.
Mission & Focus Areas
C-Path’s stated mission is to lead collaborations that accelerate drug development and advance better treatments worldwide. Its 2023 filing describes its work as advancing medical innovation and regulatory science through teams that share data, knowledge, and expertise to produce consensus-based science.
The organization’s stated program areas include rare neurodegenerative diseases, rare disease data and analytics, ataxias, polycystic kidney disease, Alzheimer’s disease, Parkinson’s disease, tuberculosis, sickle cell disease, type 1 diabetes, Duchenne muscular dystrophy, and other areas. Its website also describes the Translational Therapeutics Accelerator (TRxA), which provides funding and development guidance to academic researchers working to advance novel therapeutics.
TRxA’s FAQ says eligible applicants are faculty at universities and nonprofit institutions worldwide. Current awards are limited to small-molecule therapeutics; diagnostics, gene therapies, drug repurposing, and siRNA are listed as outside the program’s current scope. Peptidomimetics may qualify if their molecular weight is less than around 1,000 daltons.
Grantmaking
In filing year 2025, C-Path reported 17 grants totaling $3,758,536. Grant amounts ranged from $23,000 to $1,319,385, with a median of $127,093. The largest listed grants included $1,319,385 to the National Organization for Rare Disorders, $381,946 to Northwestern University, $347,500 to the University of California, San Francisco, and $234,728 to Seattle Children’s Hospital. The listed grant purposes were subawards.
Among the supported organizations, Northwestern describes its mission as excellent teaching, innovative research, and student growth. Seattle Children’s describes its mission as pediatric health and wellness through clinical care and research. The University of Pittsburgh describes itself as a public research university serving its region, state, and nation. Banner Health describes its nonprofit mission as making health care easier so life can be better.
TRxA describes three one-year funding levels: up to $250,000, $500,000, or $1,000,000 in total costs, with indirect costs limited to 10%. Funded institutions are expected to engage with TRxA and negotiate a project agreement. C-Path announced its 2026 BRIDGe request for proposals on January 21, 2026; that launch date is in the past, and no application deadline is stated in the available information.
Leadership & Key People
Leadership team and compensation from IRS filings
The 2025 filing lists the following board members: Bonnie Allin, Mara G Aspinall, Peter Barton Hutt, Karen Bernstein, Louis Breton, Timothy R Franson, Kay Holcombe, Shaun A Kirkpatrick, Alan G Levin, and James W Newman.
Critical Path Institute is led by Klaus Romero, CEO since 2025 (on filings since 2019); 14 of 28 officers listed in 2025 are compensated.
Officers on the 2025 filing
Klaus Romero
CEO
Chief Science Officer → Chief Science Officer & CEO, 2024
Chief Science Officer & CEO → CEO, 2025
On filings since 2019
40 hrs/week
$169K (2019) → $465K (2025)
Diane Stephenson
Executive Director
On filings since 2019
40 hrs/week
$171K (2019) → $261K (2025)
Marco Schito
Executive Director
Scientific Director → Executive Director, 2022
On filings since 2019
40 hrs/week
$134K (2019) → $261K (2025)
Sonya Eremenco
Executive Director
Associate Director → Executive Director, 2021
On filings since 2019
40 hrs/week
$158K (2019) → $243K (2025)
Kristen Swingle
President & COO
Chief Operating Officer & Treasurer → COO & Interim President, 2022
COO & Interim President → COO & President, 2023
On filings since 2020
40 hrs/week
$127K (2020) → $382K (2025)
Sudhir Sivakumaran
Executive Director
Vice President & Executive Director → Executive Director, 2024
On filings since 2021
40 hrs/week
$171K (2021) → $256K (2025)
Maaike Everts
Executive Director
On filings since 2024
40 hrs/week
$251K (2024) → $258K (2025)
M. Wainwright Fishburn Jr.
Chairman
Vice Chair → Vice Chairman, 2021
Vice Chairman → Chairman, 2022
On filings since 2019
1 hr/week
No compensation reported
Yi Zhang
Senior Director
New on the 2025 filing
40 hrs/week
$198K (2025)
Lewis Barbieri
Corporate Secretary
Secretary → Corporate Secretary, 2020
On filings since 2019
40 hrs/week
$118K (2019) → $150K (2025)
Richard Liwski
Chief Technology Officer
On filings since 2019
40 hrs/week
$151K (2019) → $267K (2025)
Kevin Perkins
Chief Financial Officer & Treasurer
On filings since 2022
40 hrs/week
$85K (2022) → $279K (2025)
Cheryl Coon
Vice President Programs
On filings since 2024
40 hrs/week
$237K (2024) → $322K (2025)
Collin Hovinga
Vice President Programs
On filings since 2024
40 hrs/week
$245K (2024) → $273K (2025)
Shu Chin Ma
Vice President Programs
On filings since 2024
40 hrs/week
$194K (2024) → $256K (2025)
Timothy R. Franson
Board Member
Chair → Chairman, 2021
Chairman → Board Member, 2022
On filings since 2019
1 hr/week
No compensation reported
Alan G. Levin
Board Member
On filings since 2020
1 hr/week
No compensation reported
James W. Newman
Board Member
On filings since 2020
1 hr/week
No compensation reported
Kay Holcombe
Board Member
On filings since 2020
1 hr/week
No compensation reported
Peter Barton Hutt
Board Member
On filings since 2020
1 hr/week
No compensation reported
Shaun A. Kirkpatrick
Board Member
On filings since 2020
1 hr/week
No compensation reported
Tomas Salmonson
Board Member
On filings since 2020
1 hr/week
No compensation reported
Mara G. Aspinall
Board Member
On filings since 2021
1 hr/week
No compensation reported
Jeffery Jacob
Vice Chairman
On filings since 2022
1 hr/week
No compensation reported
Karen Bernstein
Board Member
On filings since 2023
1 hr/week
No compensation reported
Bonnie Allin
Board Member
On filings since 2024
1 hr/week
No compensation reported
Louis Breton
Board Member
On filings since 2024
1 hr/week
No compensation reported
Paul Edmeier
Chief Financial Officer & Treasurer
New on the 2025 filing
40 hrs/week
No compensation reported
Former officers (34)
- Former: Daniel M. Jorgensen (2023–2024) — CEO & Board Member
- Former: Sergey Rakhilin (2023–2024) — Executive Director
- Former: Paula J. Olsiewski (2019–2023) — Board Member
- Former: Stephen J. Coons PhD (2019–2023) — Senior Vice President
- Former: Kanwaljit Singh (2023) — Executive Director
- Former: Nicholas King (2023) — Executive Director
- Former: Terina Martinez (2023) — Executive Director
- Former: Inish O'Doherty (2019–2022) — Vice President
- Former: Alastair Jj Wood (2020–2022) — Board Member
- Former: John Michael Sauer (2020–2022) — Senior Vice President
- Former: Joseph Scheeren (2020–2022) — President & CEO
- Former: Jeff Barrett (2021–2022) — Senior Vice President
- Former: Robert M. Califf (2021–2022) — Board Member
- Former: Craig Brater (2022) — Board Member
- Former: Jeffrey Jacob (2020–2021) — Board Member
- Former: Cindy Parseghian (2019–2020) — Board Member
- Former: D. Craig Brater (2019–2020) — Board Member
- Former: Lynn Hudson (2019–2020) — Chief Science Officer
- Former: Martha A. Brumfield (2019–2020) — Former President & CEO
- Former: Michael Kasser (2019–2020) — Board Member
- Former: Richard T. Myers Jr. (2019–2020) — Board Member
- Former: Steven T. Broadbent MBA (2019–2020) — Former COO & Treasurer
- Former: Ariana Mullin (2020) — Executive Director
- Former: Alan G. Levin Ms CPA (2019) — Board Member
- Former: Alastair Jj Wood Mb Chb (2019) — Board Member
- Former: Daniela Conrado (2019) — Associate Director
- Former: Honorable James C. Greenwood (2019) — Board Member
- Former: Jeffrey E. Jacob Sm (2019) — Deputy Chairperson
- Former: John-Michael Sauer PhD (2019) — Program Officer
- Former: Joseph Scheeren Pharmd (2019) — CEO & President
- Former: Kay Holcombe Ms (2019) — Board Member
- Former: Peter Barton Hutt Llb Llm (2019) — Board Member
- Former: Shaun A. Kirkpatrick Ma (2019) — Board Member
- Former: Steve Arneric PhD (2019) — Executive Director
Data from IRS Form 990 filings, 2019–2025. "On filings since" is the earliest filing we hold that lists the person; hours are average hours per week as reported.
Compensation Overview
From 2025 IRS filing
The highest reported compensation on the 2025 filing was $465K, to Dr Klaus Romero (CEO). 14 officers or directors reported compensation on that filing.
Frequently asked questions about Critical Path Institute
How much does Critical Path Institute give each year?
Critical Path Institute gave $3.8M across 17 grants in 2025, according to its 2025 IRS Form 990. In 2024 it gave $4.8M across 14 grants.
What is Critical Path Institute's typical grant size?
Critical Path Institute's median grant in 2025 was $127,093, and its average grant was $221,090, across 17 grants on its 2025 IRS Form 990. Organizations receiving their first grant from Critical Path Institute that year got $239K on average.
Where does Critical Path Institute give grants?
Critical Path Institute's top state is Massachusetts, with 35% of the grant dollars itemized on its 2025 IRS Form 990. The next largest states were California (12%) and Illinois (10%).
Does Critical Path Institute give general operating support?
Not in 2025: none of the 17 grants with a stated purpose on Critical Path Institute's 2025 IRS Form 990 were described as general or operating support. Recurring purposes include "Subaward" (17 grants).
Who are Critical Path Institute's largest grantees?
Critical Path Institute's largest 2025 grantees include National Organization for Rare Disorders ($1,319,385), Northwestern University ($381,946) and University of California ($347,500), according to its 2025 IRS Form 990. Together they received 55% of its itemized 2025 grant dollars.
How large is Critical Path Institute?
Critical Path Institute reported $38.4M in total assets on its 2025 IRS Form 990. Its revenue that year was $46.8M.
What does Critical Path Institute fund?
C-Path’s stated mission is to lead collaborations that accelerate drug development and advance better treatments worldwide. See mission & focus areas ↑
How do I apply for a grant from Critical Path Institute?
The TRxA website describes awards for academic researchers who apply and are selected. Eligibility and process details are in the grantmaking section of this profile. See how to apply ↑
What is Critical Path Institute's EIN?
Critical Path Institute's EIN (Employer Identification Number) is 20-1991334. IRS Form 990 filing data is available on this page for 2019–2025.
Data last updated October 2026. Sourced from IRS Form 990 filings. Research dossier generated October 2026.
Data update history
(8)
When this profile's IRS filing data changed on Grantable
- Updated Form 990 for fiscal year 2019 (received by the IRS April 29, 2020)
- Updated Form 990 for fiscal year 2020 (received by the IRS May 7, 2021)
- Updated Form 990 for fiscal year 2021 (received by the IRS March 21, 2022)
- Updated Form 990 for fiscal year 2022 (received by the IRS April 7, 2023)
- Updated Form 990 for fiscal year 2023 (received by the IRS March 20, 2024)
- Updated Form 990 for fiscal year 2024 (received by the IRS April 10, 2025)
- Updated Form 990 for fiscal year 2025 (received by the IRS March 2, 2026)
- IRS filings on file for fiscal years 2019–2025
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Browse active grant opportunities in Critical Path Institute's focus areas in our free grants database
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Cite this profile
Grantable. (2026). Critical Path Institute funder profile. GrantGraph. Retrieved October 16, 2026, from https://grantable.co/funders/critical-path-institute-morg_65c6000ffc094ef2b7b8a0443239feda
BibTeX
@misc{grantable_201991334_2026,
author = {{Grantable}},
title = {{Critical Path Institute funder profile}},
howpublished = {GrantGraph},
year = {2026},
url = {https://grantable.co/funders/critical-path-institute-morg_65c6000ffc094ef2b7b8a0443239feda},
note = {Accessed 2026-10-16. Data licensed CC BY 4.0}
}The figures on this page are open data under CC BY 4.0: reuse them with credit to Grantable and a link. Download the data.
Figures come from Critical Path Institute's IRS filings (methodology). AI-written summaries, news items and logos are not covered by the open licence. Spot an error? Email hello@grantable.co.
Critical Path Institute down — hundreds of funders to go?