Community Health Commission of Missouri

Generate Health STL

Saint Louis, MO

The mission of the organization is to build collective power to advocate for racially equitable policies and practices that center, support, and celebrate black families throughout their pregnancy and parenthood journeys.

St Louis Integrated Health Network

St. Louis, MO

St. Louis Integrated Health Network funds healthcare access, health equity, and community health and social-service initiatives, including safety-net provider capacity, food justice, and equitable physical activity, mainly in Metropolitan St. Louis. Its 2025 grants ranged from $7,142 to $2.51 million, with a median of $7,142. No general application process is specified; its described grant process works through participating network organizations.

Pershing Charitable Trust

St. Louis, MO

The Trust supports a broad range of work, including pediatric care, re-entry services, education, youth development, plant science, housing, and regional economic growth; 97% of its 2025 grant dollars went to Missouri. Grants ranged from $5,000 to $600,000, with a median of $30,000. It accepts unsolicited written requests, with no stated deadline.

United Way of Greater St Louis Inc

Saint Louis, MO

United Way of Greater St. Louis funds local nonprofits working on essential needs, youth success, health, financial mobility, and community stability, including direct services and efforts addressing root causes. Its 2025 grants ranged from $5,305 to $2.1 million, with a median of about $78,500; it primarily serves a 16-county region in Missouri and Illinois. It accepts applications through listed funding cycles, including a 2027 Targeted Fund cycle due October 12, 2026.

Trio Foundation of St Louis

St. Louis, MO

The Trio Foundation funds equity of opportunity, community enhancement, arts access, ecological preservation, and environmental justice, with a focus on people who may face discrimination and needs such as housing, healthcare, and childcare. Its 2025 grants ranged from $2,500 to $50,000, with a median of $22,500, and most funding goes to St. Louis City and nearby counties. It does not accept unsolicited requests in 2026; interested organizations are asked to contact staff to schedule a meeting before applying.

The Opportunity Trust D/B/a Zest Education

St. Louis, MO

The Opportunity Trust funds public-school improvement and expansion, charter schools, educator development, early literacy, preschool access, and family and student leadership, primarily in St. Louis and through its charter-school program across Missouri. In 2025, grants ranged from $5,500 to $1,488,050, with a median award of $156,750. It does not describe open unsolicited requests: its published process invited current grantees to apply and asked other interested school or district leaders to submit an interest form.

Area Resources for Community & Human Services

St. Louis, MO

ARCHS funds human-service programs in Greater St. Louis, including child and family support, early childhood and after-school education, victim services, and workforce development. Its 2025 grants had a median of about $161,000, though awards ranged widely; it issues requests for proposals when funding is available, and its questionnaire is not a funding application.

Pecha Family Foundation

St. Louis, MO

Washington University

Saint Louis, MO

Washington University’s reported grants primarily support research at universities, medical centers, and research institutes. In 2025, awards ranged from $5,100 to $6.23 million, with a median of $77,080, and went to recipients in multiple states; the profile does not state whether it accepts unsolicited requests.

St Louis Community Foundation Inc

St. Louis, MO

The foundation supports nonprofits through its own community priorities and funds it administers for private and family foundations, including economic mobility, youth connections, and a range of other donor-directed causes. In 2024, grants ranged from $5,050 to $4 million, with a median of $20,000; community-impact funding focuses mainly on high-need ZIP codes in Missouri and Illinois, though grants also go elsewhere. It does not state whether it accepts unsolicited requests; applicants should check each funder’s criteria and deadlines.

Norman J Stupp Foundation

Clayton, MO

The Norman J Stupp Foundation supports St. Louis-based initiatives, including work with children and families, youth, education, food access, health, and community spaces. Its grants typically range from $5,000 to $50,000, with a median of $10,000. It does not limit giving to preselected organizations; contact Commerce Trust Company for an application.

St Louis Community Foundation

St. Louis, MO

The St. Louis Community Foundation’s discretionary grants focus on economic mobility—such as housing, financial health, and jobs—and youth connections, including early education, educational innovation, and scholarships; it also administers grants for private and family foundations with their own priorities. Its 2024 itemized grants had a median of about $11,000, and recipients were primarily in Missouri, with others in Kansas, New York, Illinois, and Colorado.