Carolinas Center for Medical Excellence Found

Duke Energy Foundation

Charlotte, NC

The Duke Energy Foundation funds workforce development, local economic development and recovery, disaster resilience, conservation, and economic opportunity in communities across North Carolina, South Carolina, Florida, Ohio, Kentucky, and Indiana. It reports more than $30 million in annual charitable grants; awards vary widely, with a 2024 median of $25,000, and applications of $20,000 or less are accepted on a rolling basis. Applicants should contact their local Foundation representative before applying.

The Leon Levine Foundation

Charlotte, NC

The Leon Levine Foundation funds healthcare, human services, education, and Jewish community work, primarily benefiting people in North and South Carolina. Its 2025 grants ranged from $10,000 to $2.1 million, with a median of $60,000. It accepts unsolicited requests through an eligibility quiz and portal, starting with a letter of inquiry.

Foundation for the Carolinas

Charlotte, NC

Foundation For The Carolinas funds nonprofits and other eligible organizations working in areas such as education, health and human services, the environment, youth development, and animal welfare, primarily across 13 counties in North and South Carolina. Its 2024 grants had a median of $25,000, though amounts varied widely; most grants are donor-recommended and have no application process, while some competitive programs accept applications under program-specific rules.

North Carolina Association of Free and Charitable Clinics Inc

Charlotte, NC

The North Carolina Association of Free & Charitable Clinics funds member clinics that provide healthcare to uninsured and underinsured people in North Carolina. In 2024, it made 62 grants ranging from $5,880 to $245,600, with a median of $61,183. The profile does not state whether it accepts unsolicited requests.

Dogwood Health Trust

Asheville, NC

Dogwood Health Trust funds organizations working to improve health and wellbeing through housing, education, economic opportunity, and health and wellness in Western North Carolina’s 18 counties and the Qualla Boundary. Its 2024 grants ranged from $2,000 to $21 million, with a median of $37,500; amounts vary by opportunity.

Sisters of Charity Foundation of South Carolina

Cleveland, OH

The Sisters of Charity Foundation of South Carolina funds nonprofits and coalitions serving South Carolina, focusing on systems change in economic mobility and housing security, plus community engagement activities; health care systems change grants are by invitation only. Recent grants ranged from $5,500 to $100,000, with a median of $25,000; current Systems Change grants offer up to $75,000 annually for local or regional work or $100,000 for state-level work, while Community Engagement grants are up to $1,500. Systems Change Grants currently accept Letters of Intent through an inquiry process; unsolicited requests for health care grants are not accepted.

The Cannon Foundation Inc

Concord, NC

The Cannon Foundation funds capital and equipment projects in human services, higher education, healthcare, and community programs, primarily for organizations with significant operations in North Carolina. Its 2025 grants ranged from $2,500 to $500,000, with a median award of $50,000. Organizations begin with an online inquiry form; the profile does not state whether unsolicited requests are accepted.

Reynolds American Foundation

Winston-Salem, NC

United Way of Greenville County Inc

Greenville, SC

United Way of Greenville County funds multi-year grants to organizations addressing poverty through affordable housing, childcare, postsecondary education and job credentials, and transportation. Its 2024 grants ranged from $5,118 to $252,389, with a median of $35,000; funding focuses on organizations serving Greenville County, South Carolina. The current grant cycle is closed, and the next is expected in 2026; the profile does not state whether unsolicited requests are accepted.

The Duke Endowment

Charlotte, NC

The Duke Endowment funds child and family well-being, health care, higher education at four named colleges and universities, and rural churches, primarily in North Carolina and South Carolina. Its 2024 grants ranged from $7,000 to $6.8 million, with a median of $200,000. The application process varies by program; the profile does not state whether unsolicited requests are accepted.

American Electric Power Foundation

Wilmington, DE

The American Electric Power Foundation funds STEM education, basic needs such as hunger and housing, social justice, and environmental protection. Its 2025 grants had a median of $10,000, with awards ranging from $500 to about $1.43 million; funding is concentrated in Ohio, with grants also going to states including Texas, Indiana, Virginia, and West Virginia. It accepts applications only from preselected organizations invited through a local AEP Operating Company and does not accept unsolicited requests.

Puget Sound Energy Foundation

Wilmington, DE

The Puget Sound Energy Foundation funds nonprofits serving communities where PSE has a service or generation presence, primarily in Washington, across household needs, education and workforce pathways, climate resilience, and community safety. Grants vary widely; in 2024 they ranged from $13 to $100,000, with a $500 median, while its 2026 disaster-focused competitive program offers up to $15,000. It generally does not accept unsolicited requests, but eligible local nonprofits can apply through that competitive program.