Alpha-1 Foundation Inc
Alpha-1 Foundation Inc is a public charity based in Coral Gables, Florida. Founded in 1995, it funds research and programs related to Alpha-1 Antitrypsin Deficiency, with the stated aim of finding a cure and improving the lives of people affected by the condition worldwide.
Alpha-1 Foundation Inc at a glance
In short: Alpha-1 Foundation Inc gave $1.8M across 19 grants in 2025 (avg $95K), top state Florida. 47% of 2025 grantees were new. Source: 2025 IRS Form 990.
- Annual giving (2025)
- $1,812,816
- -19.1% vs 2024
- Grants made (2025)
- 19
- +35.7% vs 2024
- Average grant
- $95,411
- -40.4% vs 2024
- Median grant
- $63,368
- Total assets
- $47,454,771
- +6.7% vs 2024
- New grantees (estimate)
- 47% first-time grantees (9 of 19, 2025; small sample)
- Primary geography
- Florida (26% of itemized 2025 grant dollars)
- Latest 990 filing
- Form 990, 2025 View filing
Data from IRS Form 990, 2025; updated October 2026. New grantees are estimated by matching recipient names across years (methodology).
How to apply to Alpha-1 Foundation Inc
- How to Apply
-
Submit a letter of intent during the annual grant cycle. Applicants whose letters are selected are invited to submit a full proposal.
- Contact
Mailing address: 3300 Ponce De Leon Blvd, Coral Gables, FL 33134-7211
Phone: (305) 567-9888
Website: https://alpha1.org
Application details from Grantable's research on the foundation's public materials; confirm on its website before applying.
Open Grants
11 open opportunities from Alpha-1 Foundation Inc
Alpha-1 Foundation Ab Rees Fast Track Awards
Alpha-1 Foundation Inc
Amount
Up to $50K
Deadline
Deadline not published
Alpha-1 Foundation In-Cycle Research Grants
Alpha-1 Foundation Inc
Amount
Varies
Deadline
Deadline not published
Alpha-1 Foundation Pilot and Feasibility Grants
Alpha-1 Foundation Inc
Amount
Varies
Deadline
Deadline not published
Who Alpha-1 Foundation Inc funds
How this funder distributes its grants
Top Recipients
Top 10 recipients in 2025
The largest 2025 recipient was University of Florida ($471K). Together the top 10 received $1.5M.
Grant Size Distribution
79 grants across all recorded years
The most common grant size was under $50K: 25 grants of 79 (32%).
Geographic Focus
Where this funder awards grants
The foundation is based in Coral Gables, Florida. Its 2025 grant dollars went to recipients in multiple states, led by Florida (26%), Massachusetts (20%), Texas (14%), California (10%), and Colorado (9%). Its website describes research investment and collaboration across North America, Europe, the Middle East, and Australia.
Grant Distribution by State
Share of 2025 grant dollars across all 19 itemized grants.
States
Cities
Is Alpha-1 Foundation Inc open to new grantees?
47%
first-time grantees, 2025
In 2025, 9 of 19 grantees (47%) were first-time recipients. With only 19 grantees, that is a small sample: one grantee more or less moves the share by about 5 points. First grants averaged $57K; repeat grants $130K. How we count
Medians: $39K first-time, $97K repeat.
- 53% of 2025 grantees were also funded in 2024. Method
- Giving held roughly steady from 2022 to 2025 (+5%). Method
Estimate from itemized grant lists in IRS Form 990 filings (2021–2025). Recipient names are matched across years, so a renamed or misspelled grantee can look new; grants to individuals are left out. Methodology.
Giving History
Giving Over Time
Total grant dollars and number of grants per year
From 2021 to 2025, annual grant giving ranged from $1.6M (2023) to $2.2M (2024). In 2025 it made 19 grants totaling $1.8M.
Grants by year
Grant recipients and amounts by year
| Recipient | Purpose | Amount |
|---|---|---|
| University of Florida Gainsville, FL | Research | $470,549 |
| Regents of the Univ of California Davis, CA | Research | $178,944 |
| Brigham & Women's Hospital Inc Boston, MA | Research | $174,125 |
| Baylor College of Medicine Houston, TX | Research | $174,051 |
| National Jewish Health Denver, CO | Research | $99,723 |
| Univeristy of Cincinnati Cleveland, OH | Research | $99,500 |
| Clemson University Clemson, SC | Research | $99,452 |
| Boston Medical Center Boston, MA | Research | $95,267 |
| The University of Texas Austin, TX | Research | $74,000 |
| Boston Univ of Internal Medicine Boston, MA | Research | $63,368 |
Ready to take the next step with Alpha-1 Foundation Inc?
Financial History
Multi-year comparison from IRS filings
| Filing year | Total Assets | Revenue | Expenses | Grants paid | Grants | Net Investment Income |
|---|---|---|---|---|---|---|
| 2025 | $47,454,771 | $13,755,427 | $13,980,782 | $1,812,816 | 19 | $3,211,865 |
| 2024 | $44,464,081 | $11,614,380 | $10,093,036 | $2,240,888 | 14 | $2,181,265 |
| 2023 | $37,662,654 | $10,453,299 | $8,547,943 | $1,637,134 | 14 | $1,628,280 |
| 2022 | $35,496,616 | $10,890,084 | $6,364,206 | $1,718,552 | 16 | $1,460,203 |
| 2021 | $34,603,486 | $10,942,439 | $6,256,103 | $1,937,237 | 16 | $2,701,074 |
Research compiled by Grantable AI from public sources. Last updated October 2026.
Mission & Focus Areas
The foundation’s mission is to find a cure for Alpha-1 Antitrypsin Deficiency and improve the lives of people affected by it worldwide. Its grant program supports basic and clinical research related to Alpha-1, researcher development, and ethical, legal, and social issues affecting people with genetic conditions.
The foundation’s 2025 grants included research awards to universities and medical institutions. Grantees describe their own missions in different terms: Baylor College of Medicine says it advances human health through patient care, research, education, and community services; National Jewish Health says it aims to heal, discover, and educate; and Boston Medical Center says it provides excellent, accessible health services regardless of a person’s status or ability to pay.
Grantmaking
In filing year 2025, the foundation reported 19 grants totaling $1,812,816. Grant sizes ranged from $7,500 to $470,549, with a median of $63,368. The largest awards listed were $470,549 to the University of Florida for research, $178,944 to the Regents of the University of California at Davis for research, $174,125 to Brigham & Women’s Hospital for research, $174,051 to Baylor College of Medicine for research, and $99,723 to National Jewish Health for research.
The foundation’s 2026–2027 in-cycle grants program uses a letter-of-intent process; selected applicants are invited to submit a full proposal. Listed award categories include career development, pilot and feasibility, clinical pilot, postdoctoral fellowship, research, and ethical, legal, and social issues grants. The postdoctoral fellowship offers up to $75,000 per year for two years, and travel grants are listed at up to $1,000. The foundation says its Grants Advisory Committee reviews applications for research quality and relevance; prospective grantees are screened against the U.S. Treasury’s OFAC list, and grants receive quarterly peer review before subsequent payments. Final research reports are peer-reviewed before final payments.
Leadership & Key People
Leadership team and compensation from IRS filings
The 2025 filing lists Jon Hagstrom as chair, Kenneth Irvine as treasurer, Peggy Iverson as vice chair, and Catherine Vernon as director/secretary. It also lists Virginia Clark as physician director and Alice Turner, Ann Knebel, Darrell Kotton, and Erin Carr as directors. Fred C. Walsh is listed as vice chair through September 2024.
Alpha-1 Foundation Inc is led by Scott T. Santarella, President & CEO on every filing since 2021; 7 of 19 officers listed in 2025 are compensated.
Officers on the 2025 filing
Scott T. Santarella
President & CEO
On filings since 2021
40 hrs/week
$77K (2022) → $352K (2025)
Jon Hagstrom
Chair
Treasurer → Chair, 2022
On filings since 2021
8 hrs/week
No compensation reported
Angela T. McBride
Senior Director of Corporate Relations
Sen Director Corp Relations → Senior Director of Corporate Relations, 2025
On filings since 2021
40 hrs/week
$109K (2021) → $136K (2025)
Randel H. Plant
Senior Director of Research Programs
Sen Director Research Progs → Senior Director of Research Programs, 2025
On filings since 2021
40 hrs/week
$122K (2021) → $158K (2025)
Linda M. Rodriguez
Senior Development Director
Senior Director Development → Development Director, 2023
Development Director → Senior Development Director, 2025
On filings since 2022
40 hrs/week
$105K (2022) → $137K (2025)
Jeanne Kushner
Senior Director of Communications
On filings since 2024
40 hrs/week
$101K (2024) → $111K (2025)
Adriana Arce
Sen Director of Executive Operations & Scientific Events
New on the 2025 filing
40 hrs/week
$107K (2025)
Ann Knebel
Director
Director → Secretary, 2022
Secretary → Director, 2023
On filings since 2021
4 hrs/week
No compensation reported
Jennifer Jopp
Director
Secretary → Director, 2023
On filings since 2021
4 hrs/week
No compensation reported
Catherine Vernon
Director & Secretary
Director → Director & Secretary, 2025
On filings since 2022
4 hrs/week
No compensation reported
Darrell Kotton
Director
On filings since 2023
4 hrs/week
No compensation reported
Mark Brantly
Director
On filings since 2023
4 hrs/week
No compensation reported
Virginia Clark
Physician Director
On filings since 2023
8 hrs/week
No compensation reported
Alice Turner
Director
New on the 2025 filing
4 hrs/week
No compensation reported
Erin Carr
Director
New on the 2025 filing
4 hrs/week
No compensation reported
Mark B. Delvaux
CFO
Vice President & CFO → CFO, 2022
On filings since 2021
10 hrs/week
$100K (2025)
Fred C. Walsh
Vice Chair
On filings since 2021
8 hrs/week
No compensation reported
Kenneth Irvine
Treasurer
Director → Treasurer, 2022
On filings since 2021
8 hrs/week
No compensation reported
Peggy Iverson
Secretary & Vice Chair
Director → Secretary, 2023
Secretary → Secretary & Vice Chair, 2025
On filings since 2021
8 hrs/week
No compensation reported
Former officers (7)
- Former: Faron Schonfeld (2021–2024) — Director
- Former: Noel G McElvaney (2021–2024) — Director
- Former: Martin R. Zamora (2021–2023) — Director Emeritus
- Former: Elizabeth Johnson (2021–2022) — Director
- Former: James K. Stoller (2021–2022) — Director
- Former: Jeanine M. D'armiento (2021–2022) — Immediate Past Chair
- Former: Miriam A. O'Day (2021–2022) — President & CEO
Data from IRS Form 990 filings, 2021–2025. "On filings since" is the earliest filing we hold that lists the person; hours are average hours per week as reported.
Compensation Overview
From 2025 IRS filing
The highest reported compensation on the 2025 filing was $352K, to Scott Santarella (President and CEO). 7 officers or directors reported compensation on that filing.
Frequently asked questions about Alpha-1 Foundation Inc
How much does Alpha-1 Foundation Inc give each year?
Alpha-1 Foundation Inc gave $1.8M across 19 grants in 2025, according to its 2025 IRS Form 990. In 2024 it gave $2.2M across 14 grants.
What is Alpha-1 Foundation Inc's typical grant size?
Alpha-1 Foundation Inc's median grant in 2025 was $63,368, and its average grant was $95,411, across 19 grants on its 2025 IRS Form 990. Organizations receiving their first grant from Alpha-1 Foundation Inc that year got $57K on average.
Where does Alpha-1 Foundation Inc give grants?
Alpha-1 Foundation Inc's top state is Florida, with 26% of the grant dollars itemized on its 2025 IRS Form 990. The next largest states were Massachusetts (20%) and Texas (14%). The most frequent recipient cities were Boston, MA (4 grants) and Denver, CO (3 grants).
Does Alpha-1 Foundation Inc give general operating support?
Not in 2025: none of the 19 grants with a stated purpose on Alpha-1 Foundation Inc's 2025 IRS Form 990 were described as general or operating support. Recurring purposes include "Research" (19 grants).
Who are Alpha-1 Foundation Inc's largest grantees?
Alpha-1 Foundation Inc's largest 2025 grantees include University of Florida ($470,549), Regents of the Univ of California ($178,944) and Brigham & Women's Hospital Inc ($174,125), according to its 2025 IRS Form 990. Together they received 45% of its itemized 2025 grant dollars.
How large is Alpha-1 Foundation Inc?
Alpha-1 Foundation Inc reported $47.5M in total assets on its 2025 IRS Form 990. Its revenue that year was $13.8M.
What does Alpha-1 Foundation Inc fund?
The foundation’s mission is to find a cure for Alpha-1 Antitrypsin Deficiency and improve the lives of people affected by it worldwide. See mission & focus areas ↑
How do I apply for a grant from Alpha-1 Foundation Inc?
Submit a letter of intent during the annual grant cycle. Eligibility and process details are in the grantmaking section of this profile. See how to apply ↑
What is Alpha-1 Foundation Inc's EIN?
Alpha-1 Foundation Inc's EIN (Employer Identification Number) is 65-0585415. IRS Form 990 filing data is available on this page for 2021–2025.
Data last updated October 2026. Sourced from IRS Form 990 filings. Research dossier generated October 2026.
Data update history
(6)
When this profile's IRS filing data changed on Grantable
- Updated Form 990 for fiscal year 2021 (received by the IRS March 4, 2022)
- Updated Form 990 for fiscal year 2022 (received by the IRS February 16, 2023)
- Updated Form 990 for fiscal year 2023 (received by the IRS March 25, 2024)
- Updated Form 990 for fiscal year 2024 (received by the IRS May 15, 2025)
- Added Form 990 for fiscal year 2025 (received by the IRS May 15, 2026)
- IRS filings on file for fiscal years 2021–2024
Explore Open Grants
Browse active grant opportunities in Alpha-1 Foundation Inc's focus areas in our free grants database
Similar Funders
Funders that support many of the same organizations
President and Fellows of Harvard College
Cambridge, MA
Harvard’s grantmaking primarily supports research and education, including research awards and sub-awards to universities, hospitals, and research institutes. In 2025, it reported 352 grants ranging from $5,002 to $27.4 million, with a median of $123,018; recipients were concentrated in Massachusetts, which received 64% of grant dollars. The profile does not state whether Harvard accepts unsolicited requests.
Assets
$79.9B
Grants
352
Total Given
$273.3M
American Heart Association Inc
Dallas, TX
The American Heart Association funds basic, clinical, behavioral, translational and population research on cardiovascular, cerebrovascular and brain health, along with research training and education programs. In 2025 it awarded 833 grants totaling about $198 million; amounts ranged from $5,000 to nearly $9.93 million, with a median of $20,000. Research awards are for eligible U.S.-based nonprofit institutions, and the profile describes a formal proposal process but does not state whether unsolicited requests are accepted.
Assets
$2.0B
Grants
833
Total Given
$198.2M
American Cancer Society Inc
Atlanta, GA
The American Cancer Society funds cancer research, patient support, and advocacy, including grants to researchers, institutions, and related organizations. Its 2025 grants ranged from $5,648 to $9.6 million, with a median of $15,000; research funding supports institutions across the United States. It accepts applications for specific research programs through ProposalCentral, but the profile does not state whether it accepts unsolicited requests generally.
Assets
$1.7B
Grants
509
Total Given
$23.1M
Silicon Valley Community Foundation
Mountain View, CA
Silicon Valley Community Foundation funds work in areas such as housing, economic security, education, health, the environment, arts and culture, and civic engagement, with Community Action Grants supporting local, community-led organizations in San Mateo and Santa Clara counties. Its 2024 grants had a median of $51,716, though amounts varied widely; applications depend on the program, and SVCF states that it does not accept unsolicited proposals for advised funds.
Assets
$12.3B
Grants
3,576
Total Given
$3.2B
Vanderbilt University Medical Center
Nashville, TN
Vanderbilt University Medical Center supports medical and scientific research, health and educational programs, and related institutional purposes, with grants to universities, medical centers, and research organizations. Its 2025 grants had a median of about $116,000, though awards ranged widely; recipients were based across the U.S., with the most funding going to Tennessee. The profile does not state whether it accepts unsolicited requests.
Assets
$7.8B
Grants
246
Total Given
$125.1M
Cornell University
Ithaca, NY
Cornell funds education, research—especially research grants—medical services, and public-service activities, with grants concentrated in New York and also reaching recipients across the U.S. In 2025, its grants ranged from $5,043 to $5.66 million, with a median of about $96,000. The profile does not state whether Cornell accepts unsolicited requests.
Assets
$19.8B
Grants
338
Total Given
$126.7M
More similar funders
More Funders in Florida
Cite this profile
Grantable. (2026). Alpha-1 Foundation Inc funder profile. GrantGraph. Retrieved October 11, 2026, from https://grantable.co/funders/alpha-1-foundation-inc-morg_a53500c0421d4dac824fddaaa983a99c
BibTeX
@misc{grantable_650585415_2026,
author = {{Grantable}},
title = {{Alpha-1 Foundation Inc funder profile}},
howpublished = {GrantGraph},
year = {2026},
url = {https://grantable.co/funders/alpha-1-foundation-inc-morg_a53500c0421d4dac824fddaaa983a99c},
note = {Accessed 2026-10-11. Data licensed CC BY 4.0}
}The figures on this page are open data under CC BY 4.0: reuse them with credit to Grantable and a link. Download the data.
Figures come from Alpha-1 Foundation Inc's IRS filings (methodology). AI-written summaries, news items and logos are not covered by the open licence. Spot an error? Email hello@grantable.co.
Alpha-1 Foundation Inc down — hundreds of funders to go?