The Alpha-1 Foundation is committed to finding a cure for Alpha-1 Antitrypsin Deficiency and to improving the lives of people affected by Alpha-1 worldwide.
Financial Overview
From 2024 IRS Form 990-PF · View filing
Total Assets
$44.5M
+18.1% YoY
Annual Giving
$2.2M
+36.9% YoY
Grant Count
14
+0.0% YoY
Avg Grant Size
$160K
+36.9% YoY
About Alpha-1 Foundation Inc
Based on IRS filings
Alpha-1 Foundation Inc is a nonprofit organization focused on Health, based in MIAMI, FL. IRS filing data is available from 2021 through 2024. As of 2024, the organization holds $44.5M in total assets. In 2024, it awarded 14 grants totaling $2.2M. Net investment income was $2.2M.
Focus Areas
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Geographic Focus
Where this funder awards grants
Grant Distribution by State
States
Cities
Financial History
Multi-year comparison from IRS filings
| Metric | 2024 | 2023 | 2022 |
|---|---|---|---|
| Total Assets | $44,464,081 | $37,662,654 | $35,496,616 |
| Revenue | $11,614,380 | $10,453,299 | $10,890,084 |
| Expenses | $10,093,036 | $8,547,943 | $6,364,206 |
| Qualifying Distributions | — | — | — |
| Net Investment Income | $2,181,265 | $1,628,280 | $1,460,203 |
| Distributable Amount | — | — | — |
Giving Over Time
Total grant dollars and number of grants per year
Grant Insights
How this funder distributes its grants
Top Recipients
Top 10 recipients in 2024
Grant Size Distribution
60 grants across all recorded years
Open Grants
7 open opportunities from Alpha-1 Foundation Inc
Alpha-1 Foundation: Clinical Pilot Grant
ALPHA-1 FOUNDATION INC
Amount
Up to US $75,000
Deadline
Rolling / Open
Alpha-1 Foundation: John W. Walsh Career Development Grant
ALPHA-1 FOUNDATION INC
Amount
Up to US $300,000
Deadline
Rolling / Open
Alpha-1 Foundation: Pilot and Feasibility Grant
ALPHA-1 FOUNDATION INC
Amount
Up to US $75,000
Deadline
Rolling / Open
Giving History
Grant recipients and amounts by year
Among its reported 2024 grants, the largest include University of Florida ($523,817), Brigham & Women's Hospital ($397,375), Columbia University ($234,375).
| Recipient | Purpose | Amount |
|---|---|---|
| University of Florida Gainesville, FL | Research | $523,817 |
| Brigham & Women's Hospital Boston, MA | — | $397,375 |
| Boston Medical Center Boston, MA | — | $99,500 |
| Boston University Boston, MA | — | $185,618 |
| University of Alabama Birmingham, AL | — | $124,500 |
| Columbia University New York, NY | — | $234,375 |
| National Jewish Health Denver, CO | — | $40,000 |
| University of Colorado Denver, CO | — | $70,000 |
| University of Chicago Chicago, IL | — | $62,148 |
| Clemson University Clemson, SC | — | $99,452 |
Leadership & Key People
Officers and directors from IRS filings
Compensation Overview
From 2024 IRS filing
From 2024 filing
| Name | Title | Hours | Compensation |
|---|---|---|---|
| Scott Santarella | President and CEO | 40 | $330,774 |
| Randel H Plant | Sen Dir Research Progs | 40 | $143,033 |
| Angela T McBride | Sen Dir Corp Relations | 40 | $127,368 |
| Linda Rodriguez | Development Director | 40 | $122,295 |
| Jeanne Kushner | Sr Dir of Communications | 40 | $100,532 |
| Darrell Kotton | Director | 4 | — |
| Virginia Clark | Physician Director | 8 | — |
| Fred C Walsh | Vice Chair | 8 | — |
| Jennifer Jopp | Director | 4 | — |
| Jon Hagstrom | Chair | 8 | — |
| Kenneth Irvine | Treasurer | 8 | — |
| Peggy Iverson | Secretary | 8 | — |
| Ann Knebel | Director | 4 | — |
| Noel G McElvaney | Director | 4 | — |
| Faron Schonfeld | Director | 4 | — |
| Mark Brantly | Director | 4 | — |
| Catherine Vernon | Director | 4 | — |
| Mark B Delvaux | CFO | 10 | — |
Subject Areas
Focus areas based on grantmaking activity
Frequently Asked Questions
What is Alpha-1 Foundation Inc?
Alpha-1 Foundation Inc is a nonprofit organization focused on Health, based in MIAMI, FL. It holds $44.5M in total assets as of 2024.
How large is Alpha-1 Foundation Inc?
As of 2024, Alpha-1 Foundation Inc holds $44.5M in total assets with $11.6M in annual revenue. It awarded 14 grants totaling $2.2M in 2024.
Where does Alpha-1 Foundation Inc operate?
Alpha-1 Foundation Inc has awarded grants in Alabama, California, Colorado, Connecticut, Florida, Illinois, Kansas, Kentucky, Massachusetts, Minnesota, Missouri, North Carolina, New York, South Carolina, Texas.
What size grants does Alpha-1 Foundation Inc award?
In 2024, Alpha-1 Foundation Inc awarded 14 grants totaling $2.2M — an average of about $160K per grant, based on its IRS Form 990 filings.
What is Alpha-1 Foundation Inc's EIN?
Alpha-1 Foundation Inc's EIN (Employer Identification Number) is 65-0585415. IRS Form 990 filing data is available on this page for 2021–2024.
Explore Open Grants
Browse active grant opportunities in Alpha-1 Foundation Inc's focus areas in our free grants database
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Data last updated April 2026. Sourced from IRS Form 990-PF filings.