RFP: Strategically Focused Research Network (SFRN) on Earlier Detection and Delaying Progression of Valvular Heart Disease Grant

RFP: Strategically Focused Research Network (SFRN) on Earlier Detection and Delaying Progression of Valvular Heart Disease Grant

Status: ACTIVE
Funder: American Heart Association
Amount: Up to US $4,400,000
Last Updated: December 06, 2025

Summary

The American Heart Association is seeking proposals for the RFP: Strategically Focused Research Network (SFRN) focused on the earlier detection and progression delay of Valvular Heart Disease (VHD). With 2.5% of the US population affected, this initiative aims to enhance understanding and improve diagnosis and treatment strategies for VHD, particularly in underrecognized and advanced cases. The network will support research in both human studies and animal models to tackle this growing health concern.

Overview

Valvular Heart Disease Valvular heart disease (VHD) is a common cardiovascular condition in which one or more heart valves are stenotic or regurgitant. If left untreated, VHD can eventually lead to heart failure, arrhythmia, recurrent hospital admissions, reduced quality of life, and early morbidity and mortality. With 2.5% of the US population diagnosed with VHD, and the increased prevalence in aging populations, VHD is a growing global health concern. Recent data confirm that VHD is often underrecognized and poorly detected in its early stages, leading to diagnosis and intervention only once the disease becomes symptomatic and advanced. The lack of robust population-based screening and variable accessibility to advanced imaging results in many people being diagnosed late, especially in lower-resource settings and among the elderly. Purpose The intent of this initiative is to support a collaborative network of researchers whose collective efforts will lead to enhanced understanding of the earlier detection and/or delaying progression of valvular heart disease. Therefore, this Request for Proposals seeks applications that can address these critical questions and stimulate significant advances in these areas of valvular heart disease. All proposed projects must address valvular heart disease. Within that context and as presented above, an array of potential areas of investigation exists. Both human studies and appropriately designed animal models that can foster understanding of valvular heart disease may be proposed.

Eligibility

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