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Readthrough Therapies for RYR-1-Related Disease Due to Nonsense Variants Research Grant

THE RYR-1 FOUNDATION

Funding Amount

Varies

Deadline

May 1, 2026

23 days left

Grant Type

foundation

Overview

Readthrough Therapies for RYR-1-Related Disease Due to Nonsense Variants Research Grant

Funder: The RYR-1 Foundation

Geographic Scope: International (researchers from around the world are eligible)

Focus Areas:

  • Readthrough therapies for RYR-1-Related Disease (RYR-1-RD) due to nonsense variants

  • Small molecule readthrough therapies

  • tRNA-based readthrough therapies

  • Research using nonsense RYR-1-RD mouse models
  • Rationale for RPA:
    1. Clinical severity of RYR-1-RD patients with nonsense variants
    2. Ongoing development of a nonsense RYR-1-RD mouse model
    3. Growing field of readthrough therapies

    Eligibility: Open to investigators; institutional affiliation required

    Contact Information:

  • Email: info@ryr1.org

  • Phone: 724/986-8288

  • Address: The RYR-1 Foundation, P.O. Box 13312, Pittsburgh, PA 15243
  • Background: The RYR-1 Foundation is dedicated to funding research in RYR-1-Related Diseases through a competitive grant review process. Since inception, the organization has invested more than $1.8 million in groundbreaking research and currently supports over $800,000 in RYR-1-RD research.

    How to Apply

    Application Format and Requirements

    Required Application Components:
    1. Title Page (Project Title) of the RYR-1-Related Diseases (RYR-1-RD) Project
    2. Enable Other Users to Access this Proposal Information/Acknowledgements
    3. Applicant/PI Institution & Contacts
    4. Key Personnel (including short curriculum vitae or NIH Biosketch)
    5. Abstract
    6. Impact Statement
    7. Preliminary/Supporting Data
    8. Budget Period Detail
    9. Budget Summary and Justification
    10. Organization Assurances
    11. Attachments
    12. Signature Page

    Detailed Instructions: Applicants should click the link provided on the Apply Now page for detailed submission instructions.

    Focus Areas & Funding Uses

    Fields of Work

    science-research

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