IWMF Pilot Clinical Trial Grants

Applying for a Research Grant
IWMF seeks applications for research and clinical studies that will deliver meaningful therapeutic benefits for Waldenstrom macroglobulinemia (WM) patients within the next 3–5 years. Grant amounts range from $250K–$1M over 2–4 years, with a separate award to support young investigators.
Working in partnership with our world-class Scientific Advisory Committee, IWMF has developed an updated 2026 Strategic Research Agenda to advance innovative discoveries, support novel clinical trials, and foster collaborations that will continue to revolutionize treatments for WM.
IWMF seeks to support independent investigators affiliated with academic institutions using investigator-initiated trials (IITs) to undertake clinical studies of novel agents, novel combinations, or new immunotherapies with potential for clinical breakthroughs in Waldenstrom macroglobulinemia (WM) patients. These clinical studies are designed to demonstrate proof-of-concept and produce compelling results in a limited number of patients. Successful study results will provide validation to initiate larger clinical studies to achieve new therapy inclusion in NCCN Guidelines, FDA approval, or other comparable regulatory approvals in the future.
Importantly, studies should be designed to achieve complete responses and MRD-negativity, leading to the IWMF’s goal of enhancing long-term disease control (a functional cure) and ultimately, complete cures (discontinuation of any therapy). Applicants should provide a detailed explanation of the proposed rationale, prior clinical data to support the thesis, and a clear rationale for the overall duration and projected schedule for milestone-based payments throughout the Grant period.

Eligibility

Applicants must hold an MD, PhD, or equivalent degree and work in domestic or foreign non-profit organizations, such as universities, colleges, hospitals, or laboratories. Applicants should have an independent research or academic position. Applicants need not be US citizens, and there are no restrictions on applicant age, race, gender, or creed. Applicants can apply for more than one Grant.

Ineligibility

Applicants from non-academic facilities and postdoctoral positions are not eligible.