Alpha-1 Foundation: Pilot and Feasibility Grant

Alpha-1 Foundation: Pilot and Feasibility Grant

Status: ACTIVE
Funder: Alpha 1 Foundation Inc
Amount: Up to US $75,000
Last Updated: December 26, 2025

Summary

The Alpha-1 Foundation's Pilot and Feasibility Grant aims to advance research into Alpha-1 Antitrypsin Deficiency by funding innovative projects that generate or test new hypotheses. Grants of up to $75,000 are available for one year, encouraging researchers to explore new methods and ideas that may lead to effective therapies. This program not only supports groundbreaking science but also aims to foster the next generation of clinical researchers in this critical field.

Overview

Alpha-1 Foundation Our Mission The Alpha-1 Foundation is committed to finding a cure for Alpha-1 Antitrypsin Deficiency and to improving the lives of people affected by Alpha-1 worldwide. Grants Awards Program The Grants Award Program is the Alpha-1 Foundation’s mechanism to fund a broad range of research that leads to improvements in the lives of people living with AAT Deficiency. Goals The specific goals of the Program are: to promote basic science and clinical research related to the alpha-1 antitrypsin protein and AAT Deficiency;to attract and train clinical researchers for the study of AAT Deficiency;to support and encourage established scientists to work on clinical problems and ethical, legal, and social issues within the field of AAT research (with a preference given to new investigators); and ultimately,to develop effective therapies for the clinical manifestations of AAT Deficiency. The Alpha-1 Foundation will support a broad spectrum of research projects involving basic science, translational and clinical research, and ethical, legal, and social issues. Pilot and Feasibility The objective of this grant is to provide funds to encourage the development and testing of new hypotheses and/or new methods in research areas relevant to AAT Deficiency.  Proposed work must be hypothesis generating or hypothesis testing, reflecting innovative approaches to important questions in AAT research or development of novel methods, and providing sufficient preliminary data to justify the Foundation’s support.  Results from Pilot and Feasibility Grants should lead to the submission of applications for funding from other agencies (i.e. NIH). At the conclusion of the funding term, applicants are expected to apply for further funding by other mechanisms or from outside agencies.  The award is not intended to support continuation of programs begun under other granting mechanisms. Funding Up to $75,000 for a one-year period.

Eligibility

We've imported the main document for this grant to give you an overview. You can learn more about this opportunity by visiting the funder's website. The Alpha-1 Foundation requires that each applicant allocate $1,000 of the total budget to pay for travel to the Alpha-1 Foundation’s Biennial Investigators’ Meeting for the first year of the proposal’s period of performance. In case the applicant cannot attend the Investigators’ Meeting, the $1,000 budgetary line item is not refundable.

Ineligibility

Please note that the Alpha-1 Foundation does not accept LOIs or grant applications from pharmaceutical companies, biotechs, or industry for its in-cycle grants programs. These entities may not be collaborators on any proposals.  Any individual who received an Alpha-1 Foundation Research Grant in the previous year’s grant cycle is not eligible to apply for an in-cycle grant in the current cycle. Major equipment may not be requested as part of a grant application, in accordance with Alpha-1 Foundation policies. Major equipment is defined as equipment that costs more than $500.The Alpha-1 Foundation does not pay for indirect costs, facilities and administrative costs or overhead costs. Applicants are not eligible to receive a second year of additional funding for a Pilot and Feasibility Grant but are encouraged to apply to external funding sources (i.e., NIH) to continue research initiated as a Foundation grantee.