The Vincent & Harriet Palisano

Community Foundation for Greater Buffalo

Buffalo, NY

The Community Foundation for Greater Buffalo funds nonprofits and community initiatives addressing racial and ethnic equity, economic mobility, environmental resilience, and regional arts and culture, primarily across Western New York’s eight counties. Its 2024 grants ranged from $5,100 to $1,790,661, with a median of $23,220; it accepts applications through its competitive process, which requires a full electronic application.

TW LK Mills & Tr Mills Scholar Tr

Norwich, NY

James H Cummings Foundation Inc

Buffalo, NY

The foundation funds capital projects for tax-exempt nonprofits, with interests in medical research, science and post-secondary medical education, and services for vulnerable children and adults. It gives in Buffalo, Toronto, and Hendersonville, North Carolina; 2025 grants ranged from $2,560 to $115,600, with a median of $30,195. Applications begin with a letter of intent through its online portal; whether unsolicited requests are accepted is not stated.

The Peter and Elizabeth C Tower

Getzville, NY

The Peter and Elizabeth C. Tower Foundation funds services and systems change for young people up to age 26 affected by intellectual or learning disabilities, mental health issues, or substance use disorders in parts of Western New York and Eastern Massachusetts. Its 2025 median grant was about $34,000, though awards varied widely. It accepts preliminary requests or inquiries; full proposals are by invitation only.

The Ralph C Wilson Jr Foundation

Detroit, MI

The Ralph C. Wilson, Jr. Foundation funds active lifestyles, preparation for success, caregiver support, entrepreneurship and economic development, and nonprofit-sector innovation in Southeast Michigan and Western New York. Its 2024 median grant was $100,000, though awards vary widely. It accepts applications year-round through an initial Letter of Inquiry; selected organizations are invited to submit a full proposal.

Mother Cabrini Health Foundation Inc

New York, NY

The foundation funds healthcare access, basic needs, workforce development, mental and behavioral health, and other projects improving the health of vulnerable people and priority populations across New York State. Its 2024 grants had a median of $200,000, with awards ranging from $100 to $4.2 million. It accepts requests through a letter-of-inquiry process, but the 2026 application period is closed.

Tower Family Fund Inc

Buffalo, NY

Tower Family Fund supports programs, organizational capacity, and community-change efforts benefiting young people up to age 26 with learning disabilities, mental illness, substance use disorders, or intellectual disabilities in Erie and Niagara Counties, New York, and Barnstable, Dukes, Essex, and Nantucket Counties, Massachusetts. In 2025, grants ranged from $500 to $2 million, with a median of $25,000. It gives only to preselected charitable organizations and does not accept unsolicited requests.

The John R Oishei Foundation

Buffalo, NY

The John R. Oishei Foundation supports community-led work advancing racial equity and financial prosperity, including education, workforce development, arts and technology, and systems change in the Buffalo-Niagara region, with priority for Buffalo’s East Side. Its 2024 grants ranged from $750 to $930,000, with a median of $20,000. It is not accepting new grant requests; organizations interested in partnership can complete its Request to Partner form.

Keybank Community Trust Ta

Brooklyn, OH

Dreamcatcher Foundation Inc

Islamorada, FL

Dreamcatcher Foundation supports higher education, food-related education, fisheries conservation, and community programs. Its 2025 grants ranged from $100 to $20,000, with a median of $1,200, and primarily went to organizations in New York and Florida. It accepts formal letter requests at any time from bona fide charitable organizations.

Jpmorgan Chase Foundation

New York, NY

The foundation supports neighborhood revitalization, underserved small businesses, financial health, and economic mobility and career pathways, with 2024 grants ranging from $4 to $4,635,000 and a median of $550. Its grants reached organizations across multiple U.S. locations, including Washington, DC, New York, California, Illinois, Washington state, and Georgia. It gives only to preselected charitable organizations and does not accept unsolicited funding requests.

The Pfizer Foundation Inc

New York, NY

The Pfizer Foundation funds locally led health programs that improve access to care and strengthen health systems, as well as health-crisis and disaster responses, worldwide. In 2024, grants ranged from $2 to $4 million, with a median of $200. It supports only preselected organizations and does not accept unsolicited requests.