O Perry Earle Jr & Louise Jordan Earle F

Scansource Charitable Foundation

Greenville, SC

The foundation funds services for underrepresented children, PreK–12 education, and community-based family support, including children’s basic needs, family well-being, and education or workforce programs. Grants typically have a median of $3,750, though 2025 awards ranged from $150 to $50,000, for organizations serving communities in its listed U.S. footprint. It accepts online applications from eligible 501(c)(3) organizations; the application window is March 1–September 30.

United Way of Greenville County Incorporated

Greenville, SC

United Way of Greenville County funds multi-year grants to organizations addressing poverty through affordable housing, childcare, postsecondary education and job credentials, and transportation. Its 2024 grants ranged from $5,118 to $252,389, with a median of $35,000; funding focuses on organizations serving Greenville County, South Carolina. The current grant cycle is closed, and the next is expected in 2026; the profile does not state whether unsolicited requests are accepted.

Prisma Health

Greenville, SC

PRISMA HEALTH funds health care, health access and disparities, community engagement, and related educational and community programs, primarily in South Carolina. In 2025, it made 76 grants ranging from $5,250 to $38.7 million, with a median grant of $15,000. The available information does not state whether it accepts unsolicited requests.

Yeargin Foundation

Greenville, SC

Don Waggoner & Zelma Waggoner Foundation

Naples, FL

The foundation supports a range of charitable organizations, including churches, universities, Habitat for Humanity affiliates, food banks, and community organizations, with most 2024 grant dollars going to Tennessee and South Carolina, followed by Florida. Grants ranged from $1,000 to $2 million, with a median of $35,335. It funds only preselected organizations and does not accept unsolicited requests.

John I Smith Charities Inc

Greer, SC

John I Smith Charities supports a range of educational, human-service, and religiously affiliated organizations, primarily in South Carolina, with additional grants in Georgia and North Carolina. Its 2025 grants ranged from $5,000 to $100,000, with a median of $25,000. The foundation accepts inquiries by contacting Jefferson V Smith Jr.; no application form or deadline is specified.

Enterprise Holdings Foundation

Saint Louis, MO

The Enterprise Holdings Foundation supports charitable and educational nonprofits in communities where Enterprise Mobility operates, focusing on health, education, arts, and disaster relief; applicants must be actively supported by an Enterprise Mobility team member, spouse, or domestic partner. Giving varies widely: it reported 9,499 grants in 2024, but its 2025 filing showed one grant of $101.4 million, so that amount is not a typical award. Applications are accepted at any time through eligible Enterprise-affiliated applicants; the Foundation does not limit giving to preselected organizations.

Spartanburg County Foundation

Spartanburg, SC

The Spartanburg County Foundation funds nonprofits and community groups serving Spartanburg County residents, with priorities including quality of life, education, economic mobility, and organizational capacity. Its itemized 2025 grants had a median of $15,500; listed programs offer awards of up to $10,000–$35,000.

Daniel-Mickel Foundation

Greenville, SC

The Daniel-Mickel Foundation supports 501(c)(3) nonprofits in education, arts and culture, health and human services, the environment, and community development, primarily serving the Greenville, South Carolina area. Its 2024 grants ranged from $100 to $117,000, with a median of $2,500; applications are accepted quarterly, and the foundation does not limit giving to preselected organizations.

Central Carolina Community Foundation

Columbia, SC

Central Carolina Community Foundation funds education, human services, health, arts and culture, community development, disaster relief, and related community initiatives through specific grant programs. Its 2025 grants had a median of $20,000, and it primarily serves 11 Midlands counties while also funding statewide and nationally. It accepts applications through its online portal during published grant periods for specific opportunities; some programs are invitation-only.

Coastal Community Foundation of South Carolina Inc

N Charleston, SC

Coastal Community Foundation of South Carolina supports nonprofits and community initiatives in education, health, human services, the environment, arts, social justice, and community development across nine coastal South Carolina counties. Its 2024 itemized grants ranged from $5,057 to $2.3 million, with a median of $16,500; competitive programs accept applications through its online portal.

Community Foundation of Greenville Inc

Greenville, SC

Community Foundation of Greenville funds nonprofits and projects in arts, education, environment, health, and human services, with a focus on Greenville County, South Carolina. Its 2026 Capacity Building Grants award $5,000–$12,500; 2024 grants had a median of $23,900. It accepts unsolicited requests through its Capacity Building Grants program.