National Down Syndrome Congress

Enterprise Holdings Foundation

Saint Louis, MO

Enterprise Holdings Foundation supports nonprofits in health, education, arts, disaster relief, reforestation, hunger relief, and community equity, with an emphasis on organizations actively supported by Enterprise employees and their families. Its reported grants range widely: 2024 giving averaged about $7,700 across 9,499 grants, while the foundation also offers awards of up to $40,000; it supports communities where Enterprise operates worldwide. Unsolicited requests are accepted at any time, but eligible applications must be submitted by an Enterprise team member or their spouse or domestic partner on behalf of a nonprofit they actively support.

The Anna and John J Sie Foundation

Denver, CO

The Anna and John J Sie Foundation supports a range of charitable work, including Down syndrome research and care, children’s health, education, film, and arts and culture. Its 2024 grants ranged from $500 to $1,437,696, with a median of $7,312, and 95% of grant dollars went to Colorado recipients. It funds only preselected organizations and does not accept unsolicited requests.

Pharmaceutical Research and Manufacturers of America

Washington, DC

PhRMA funds advocacy, public education, and health-related organizations and initiatives aligned with its biopharmaceutical policy goals; its 2024 grants had a median of $20,000, though amounts varied widely. Grants went mainly to organizations in Washington, DC, Connecticut, California, Virginia, and New York. The profile does not state whether it accepts unsolicited requests.

Melvin & Elaine Wolf Foundation

Castle Rock, CO

The Melvin & Elaine Wolf Foundation funds Colorado nonprofits focused on children’s health and education, adult health and quality of life, and reducing suffering through education and technology. Its 2025 grants ranged from $540 to $50,000, with a median of $10,000; it does not accept unsolicited requests and is not considering first-time applicants while it has a three-year waitlist.

Roberti Family Foundation for Civic Engagement Inc

Washington, DC

The Roberti Family Foundation for Civic supported charitable organizations, with 2024 grants ranging from $1,000 to $52,500 and a median of $10,000, primarily in New York, Massachusetts, Connecticut, and Washington, DC. It has terminated and is no longer making grants; it accepted only requests from preselected organizations and did not accept unsolicited requests.

Zauqi Charitable & Educational

Washington, DC

J Landis and Sharon Martin

Denver, CO

The foundation supports educational, cultural, health, and disability-related organizations, with 2025 grants concentrated in Colorado and Illinois and some funding in Arizona. It made 15 grants in 2025, ranging from $100 to $900,000, with a median of $25,000. It funds only preselected organizations and does not accept unsolicited requests.

The Fries Foundation

Wilmington, DE

The Fries Foundation supports Christian churches with safety and security training, equipment, and resources, and provides mental-health education and support for first responder spouses. Its 2025 grants ranged from $5,000 to $25,000, with a median of $25,000; its work spans the Midwest and nationwide, while most 2025 grant dollars went to Colorado and the rest to Florida. It funds only preselected charities and does not accept unsolicited requests.

PGA Tour Inc

Ponte Vedra Beach, FL

PGA TOUR Inc. supports community charities in areas including healthcare, education, youth development, disaster relief, food access, military, and the environment, especially in tournament communities across the U.S. and internationally. Its 2024 grants had a median of $16,836, though amounts ranged widely; some Positively Memphis opportunities offer $1,000–$25,000. It accepts applications quarterly for those listed Memphis opportunities; the profile does not state whether other grants accept unsolicited requests.

The Precourt Foundation

Greenwood Village, CO

The Precourt Foundation supports a range of charitable organizations, including education, arts, community, youth, and health organizations. Its 2024 grants ranged from $1,000 to $260,000, with a median of $10,000, and most funding went to organizations in Texas, Colorado, New Hampshire, California, and North Carolina. It funds only preselected organizations and does not accept unsolicited requests.

Columbus Foundation

Columbus, OH

The Columbus Foundation supports nonprofits and community initiatives in areas including arts and culture, education, youth, neighborhoods, basic needs, and capacity building, with a median 2024 grant of about $21,500. Its focus is Central Ohio, though it also funds organizations elsewhere; most grants are donor-directed and not application-based, but some programs accept applications.

The Greater Cincinnati Foundation

Cincinnati, OH

The Greater Cincinnati Foundation supports education, affordable housing, arts and culture, community well-being, neighborhood development, and basic needs, with responsive grants focused on its eight-county Greater Cincinnati service area. Its 2024 grants had a median of $20,000, while specific opportunities range from small awards to grants of up to $450,000. It offers open RFP and LOI opportunities; the profile does not state whether it accepts unsolicited requests outside those opportunities.