Iredell Health Foundation

State Employees Credit Union Foundation

Raleigh, NC

The foundation funds capital projects, regional or statewide programs, and organizational capacity building that strengthen North Carolina communities; it favors projects with broad or replicable impact and does not fund operating budgets or shortfalls. Its 2025 grants ranged from $1,250 to $1 million, with a median of $2,500. Applications are accepted at any time and typically reviewed semiannually.

Foundation for the Carolinas

Charlotte, NC

Foundation For The Carolinas funds nonprofits and other eligible organizations working in areas such as education, health and human services, the environment, youth development, and animal welfare, primarily across 13 counties in North and South Carolina. Its 2024 grants had a median of $25,000, though amounts varied widely; most grants are donor-recommended and have no application process, while some competitive programs accept applications under program-specific rules.

Dogwood Health Trust

Asheville, NC

Dogwood Health Trust funds organizations working to improve health and wellbeing through housing, education, economic opportunity, and health and wellness in Western North Carolina’s 18 counties and the Qualla Boundary. Its 2024 grants ranged from $2,000 to $21 million, with a median of $37,500; amounts vary by opportunity.

The Winston-Salem Foundation

Winston-Salem, NC

The Winston-Salem Foundation funds nonprofits and community groups serving Forsyth County, North Carolina, across areas including education, housing, health, arts, community development, and human services. Its 2024 grants had a median of $25,000; specific programs offer up to $2,000 for small grants, $30,000 for civic engagement and inclusion, and $15,000 through The Women’s Fund. It accepts applications through its grants portal for listed programs, subject to their requirements and deadlines.

North Carolina Community Foundation

Raleigh, NC

The North Carolina Community Foundation supports local needs across North Carolina, especially in rural communities, including human services, education, youth development, health, food and nutrition, arts, and scholarships. Its 2025 grants had a median award of $15,000, though amounts varied widely; organizations may apply through the relevant affiliate, giving circle, or community fund, with eligibility and deadlines varying by program.

Triangle Community Foundation Inc

Durham, NC

The foundation supports nonprofits working in cultural arts, education and youth, nonprofit capacity building, and sustainable communities, with discretionary grants focused on Durham, Orange, Wake, and Chatham Counties in North Carolina. Its 2025 grants had a median of $20,000, though amounts varied widely. Eligible nonprofits or fiscally sponsored organizations can apply through its online system during open grant cycles, so requests are accepted when a relevant cycle is open.

The Labcorp Charitable Foundation

Burlington, NC

The Labcorp Charitable Foundation funds food access, healthcare and patient services for underserved communities, STEM and youth education, and medical research and screenings. Its typical giving level is unclear: reported grants range from smaller community awards to a 2025 median of $1,328,824, though that year’s filing itemizes only two grants. It supports local communities without a stated geographic eligibility area and does not accept unsolicited requests.

The Community Foundation of Western North Carolina Inc

Asheville, NC

The Community Foundation of Western North Carolina funds nonprofits and public agencies working in cultural resources, education, human services and natural resources, with some programs also accepting faith communities. Grants serve 18 Western North Carolina counties and the Qualla Boundary; the median 2025 grant was $25,000, and the Human Services and Education program offers up to $25,000. Application access and deadlines vary by program; the profile does not state whether unsolicited requests are accepted.

The Duke Endowment

Charlotte, NC

The Duke Endowment funds child and family well-being, health care, higher education at four named colleges and universities, and rural churches, primarily in North Carolina and South Carolina. Its 2024 grants ranged from $7,000 to $6.8 million, with a median of $200,000. The application process varies by program; the profile does not state whether unsolicited requests are accepted.

The Leon Levine Foundation

Charlotte, NC

The Leon Levine Foundation funds healthcare, human services, education, and Jewish community work, primarily benefiting people in North and South Carolina. Its 2025 grants ranged from $10,000 to $2.1 million, with a median of $60,000. It accepts unsolicited requests through an eligibility quiz and portal, starting with a letter of inquiry.

The Morehead-Cain Foundation

Chapel Hill, NC

The Morehead-Cain Foundation funds the Morehead-Cain Scholars Program and undergraduate scholarships, with reported 2024 grants going to recipients in North Carolina. Its 409 grants ranged from $300 to $3,489,800, with a median of $28,200. The profile does not state whether it accepts unsolicited requests.

Food Bank of Central & Eastern NC Inc

Raleigh, NC