HM and Pearl Kyle Foundation Inc

Betty S Campbell Charitable

Florence, SC

Betty S Campbell Charitable supports organizations working in areas including food assistance, children and youth, housing, disability services, domestic violence, ministry, and health care. In 2025, it awarded 35 grants totaling $128,646, ranging from $160 to $24,000, with a median of $2,500; 90% of grant dollars went to South Carolina. It funds only preselected organizations and does not accept unsolicited requests.

Aiken Foundation Inc

Wilson, NC

Aiken Foundation Inc’s final reported grants in 2020 supported charitable organizations in South Carolina, including community, social-service, education, and animal-welfare organizations. It made 27 grants ranging from $750 to $200,000, with a median of $55,000; it accepted no unsolicited requests and gave only to preselected organizations. Its 2020 filing is marked as its final return.

Central Carolina Community Foundation

Columbia, SC

Central Carolina Community funds education, human services, health, arts and culture, community development, disaster relief, and nonprofit capacity-building, primarily in the 11-county Midlands region of South Carolina, with some statewide and national grantmaking. Its 2025 grants had a median of $20,000; eligible nonprofits may apply through the online portal during published grant periods, though some opportunities are invitation-only.

Eastern Carolina Community Foundation

Florence, SC

Eastern Carolina Community Foundation supports nonprofits addressing needs such as youth development, mental health, violence prevention, food security, housing, and services for children, families, and seniors in seven Pee Dee counties in South Carolina. Its 2024 grants ranged from $5,200 to $50,000, with a median of $15,000; Community Impact requests are limited to $10,000, and Women in Philanthropy awards are up to $7,000. It offers an annual competitive application process; the profile does not state whether it accepts unsolicited requests outside these programs.

The First Bank Foundation

Cheraw, SC

Duke Energy Foundation

Charlotte, NC

The Duke Energy Foundation funds workforce development, local economic development and recovery, disaster resilience, conservation, and economic opportunity in communities across North Carolina, South Carolina, Florida, Ohio, Kentucky, and Indiana. It reports more than $30 million in annual charitable grants; awards vary widely, with a 2024 median of $25,000, and applications of $20,000 or less are accepted on a rolling basis. Applicants should contact their local Foundation representative before applying.

Coastal Community Foundation of South Carolina Inc

N Charleston, SC

The Coastal Community Foundation of South Carolina funds nonprofits through competitive grants for areas including education, health, community development, arts, and human needs. Its 2024 grants had a median of $16,500, with awards ranging from $5,057 to $2.3 million, across nine coastal South Carolina counties. It accepts applications only for listed competitive programs, through its online portal.

Community Foundation of Greenville Inc

Greenville, SC

Community Foundation of Greenville funds nonprofits and projects in arts, education, environment, health, and human services, with a focus on Greenville County, South Carolina. Its 2026 Capacity Building Grants award $5,000–$12,500; 2024 grants had a median of $23,900. It accepts unsolicited requests through its Capacity Building Grants program.

South Carolina Christian Foundation

Spartanburg, SC

The foundation funds Christian ministries, churches, and quality-of-life organizations, with particular attention through its Community Trust Grants to Christian nonprofits in five South Carolina counties. Its 2024 grants had a median of $15,000, though awards varied widely; most grant dollars went to South Carolina, with additional funding in other states. Community Trust applicants must submit a Ministry Introduction Form and be invited to apply; the profile does not state whether other requests are unsolicited.

United Community Bank Foundation

Greenville, SC

United Community Bank Foundation funds economic empowerment, arts, housing and youth development in communities served across Alabama, Florida, Georgia, North Carolina, South Carolina and Tennessee. Its 2025 grants ranged from $250 to $16,000, with a median of $2,000. It does not accept unsolicited requests; grants go to preselected organizations.

Spartanburg County Foundation

Spartanburg, SC

The Spartanburg County Foundation funds nonprofits serving Spartanburg County residents, especially work advancing quality of life, education, economic mobility, and nonprofit capacity. Itemized grants had a median award of $15,500, though amounts varied widely; the information provided does not state whether it accepts unsolicited requests.

Community Foundation of the Lowcountry

Hilton Head Island, SC

The Community Foundation of the Lowcountry funds nonprofits working in areas such as education, health, human services, arts, environment, animal welfare, and community development in Beaufort, Colleton, Hampton, and Jasper Counties, South Carolina; its Impact Grants have a narrower service area. Grants vary widely: the 2025 median was $15,000, with awards from $5,000 to over $1.2 million. It accepts requests through grant programs that begin with a Grant Inquiry Form.