Frances and Mason Alexander Foundation

Rowland Family Foundation

Mt Pleasant, SC

Henry & Sylvia Yaschik Foundation Inc

Charleston, SC

The foundation supports specific projects and programs of qualified 501(c)(3) charities serving the greater Charleston, South Carolina, area, across secular and Jewish, health, education, conservation, and other charitable work. Grants typically range from $1,000 to $50,500, with a 2024 median of $5,000. It accepts applications; the 2026 application period ended April 30, and the foundation says to check back in February 2027 for the next period.

TD Charitable Foundation

Portland, ME

The foundation funds education, human services, housing and financial stability, nonprofit capacity-building, and community programs, with particular consideration for underserved and low- to moderate-income communities. Its stated award range is $135–$475,000, though the 2025 median grant was $10,000; it focuses primarily on Florida, New Jersey, and New York. It accepts unsolicited requests through online applications from eligible 501(c)(3) public charities in states with a TD Bank, N.A. branch.

The Richard M Schulze Family Foundation

Minneapolis, MN

The Richard M. Schulze Family Foundation funds education, health care, and human services, including college scholarships, with most support benefiting working- and middle-class families in specified Minnesota and Florida counties; it also makes some national grants. Its 2024 grants had a median of $5,000, though awards ranged from $50 to $10 million. It plans to move to invitation-only grantmaking in 2027; whether it currently accepts unsolicited requests is not stated.

Wateree Dreams Foundation

Rock Hill, SC

The Wateree Dreams Foundation funds charitable organizations, including religious, educational, healthcare, and community-service organizations, in North Carolina, South Carolina, and Georgia. Its 2025 grants ranged from $1,000 to $44,000, with a median of $3,000. It funds only preselected organizations and does not accept unsolicited requests.

The Ladies' Benevolent Society

Charleston, SC

The Ladies’ Benevolent Society funds South Carolina organizations providing medical and nursing care, senior and disability services, meals for homebound people, homelessness prevention, and support for human trafficking survivors. In 2024, it awarded 10 grants ranging from $2,000 to $26,000, with a median of $8,536. It does not accept unsolicited requests and gives only to preselected charitable organizations.

The Joanna Foundation

Sullivans Island, SC

The Joanna Foundation funds tax-exempt organizations working to strengthen communities and quality of life, including health, education, environmental stewardship, literacy, and community services. Its 2025 grants ranged from $1,000 to $50,000, with a median of $2,500; it primarily supports work in designated South Carolina counties and communities. It accepts unsolicited requests through a two-stage process beginning with an electronic Letter of Intent.

Medical Society of South Carolina

Charleston, SC

The Medical Society of South Carolina supports community health and wellness, medical education, and Roper St. Francis hospital-system projects in the tri-county area. In 2024, its 16 grants ranged from $10,000 to $145,000, with a median of $20,000. The profile does not state whether it accepts unsolicited requests.

Roper St Francis Healthcare

Ladson, SC

Healing all people with compassion, faith, and excellence.

BlueCross BlueShield of South Carolina

Columbia, SC

BlueCross BlueShield of South Carolina funds health and health care initiatives in South Carolina, especially efforts to improve access and outcomes for economically vulnerable residents; priorities include oral and mental health. Its 2025 grants ranged from $15,000 to $2,829,874, with a median award of $300,000. It funds preselected charitable organizations and does not accept unsolicited requests; Health Priority Grants applicants should contact the program administrator before submitting a Letter of Intent.

Central Carolina Community Foundation

Columbia, SC

Central Carolina Community funds education, human services, health, arts and culture, community development, disaster relief, and nonprofit capacity-building, primarily in the 11-county Midlands region of South Carolina, with some statewide and national grantmaking. Its 2025 grants had a median of $20,000; eligible nonprofits may apply through the online portal during published grant periods, though some opportunities are invitation-only.

Coastal Community Foundation of South Carolina Inc

N Charleston, SC

The Coastal Community Foundation of South Carolina funds nonprofits through competitive grants for areas including education, health, community development, arts, and human needs. Its 2024 grants had a median of $16,500, with awards ranging from $5,057 to $2.3 million, across nine coastal South Carolina counties. It accepts applications only for listed competitive programs, through its online portal.