PROMISE Study Grant (Prostate Cancer Registry Research)

PROMISE Study Grant

Full Name: PROMISE (A Prostate Cancer Registry of Outcomes and Germline Mutations for Improved Survival and Treatment Effectiveness)

Focus Areas:

• Prostate cancer research
• Germline genetic mutations (inherited genes) in prostate cancer
• Clinical trial matching and treatment options improvement
• Long-term collaborative research

Research Objectives:

• Understand the critical role of germline genetic mutations in men with prostate cancer
• Improve knowledge of genetic factors affecting prostate cancer outcomes
• Enable improved treatment options and clinical trial matching
• Identify genetic risk factors and disease progression mechanisms

Funded Institutions:

• UW Medicine (University of Washington)
• Johns Hopkins Medicine
• The Prostate Cancer Clinical Trials Consortium (PCCTC)

Key Research Activities:

• Gene identification and expression studies in prostate cancer
• Development of serum and tissue banks
• Bone biology and skeletal metastases studies
• Hereditary prostate cancer family studies (300+ families with genotype data)
• Biomarker development for detection, diagnosis, and risk evaluation
• Investigation of DNA methylation and inflammation in disease progression
• Novel targeted therapy development

Program Scope: Multi-institutional collaborative effort with national/international reach