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PROMISE Study Grant (Prostate Cancer Registry Research)

ADVANCING CANCER TREATMENT

Foundation Grants for Cancer NonprofitsGrants for Science Research

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Overview

PROMISE Study Grant

Full Name: PROMISE (A Prostate Cancer Registry of Outcomes and Germline Mutations for Improved Survival and Treatment Effectiveness)

Funder: Advancing Cancer Treatment (ACT)

Focus Areas:

  • Prostate cancer research

  • Germline genetic mutations (inherited genes) in prostate cancer

  • Clinical trial matching and treatment options improvement

  • Long-term collaborative research

    • Research Objectives:

  • Understand the critical role of germline genetic mutations in men with prostate cancer

  • Improve knowledge of genetic factors affecting prostate cancer outcomes

  • Enable improved treatment options and clinical trial matching

  • Identify genetic risk factors and disease progression mechanisms

    • Funded Institutions:

  • UW Medicine (University of Washington)

  • Johns Hopkins Medicine

  • The Prostate Cancer Clinical Trials Consortium (PCCTC)

    • Key Research Activities:

  • Gene identification and expression studies in prostate cancer

  • Development of serum and tissue banks

  • Bone biology and skeletal metastases studies

  • Hereditary prostate cancer family studies (300+ families with genotype data)

  • Biomarker development for detection, diagnosis, and risk evaluation

  • Investigation of DNA methylation and inflammation in disease progression

  • Novel targeted therapy development

    • Program Scope: Multi-institutional collaborative effort with national/international reach

    Contact: actclinicaltrials.org

    Focus Areas & Funding Uses

    Fields of Work

    cancerscience-research

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