Jeffrey Modell Foundation: Translational Research Program Grant

Jeffrey Modell Foundation: Translational Research Program Grant

Status: ACTIVE
Funder: Jeffrey Modell Foundation Inc
Amount: Up to US $250,000
Last Updated: January 28, 2026

Summary

The Jeffrey Modell Foundation's Translational Research Program aims to support innovative research in Primary Immunodeficiency. It focuses on advancing clinical applications, improving diagnostic tools, and developing therapies to enhance the quality of life for affected individuals. With over 500 genetic defects identified, this initiative seeks to bridge scientific discoveries and clinical advancements, benefiting millions suffering from these conditions globally. Grants of up to $250,000 over two years are available for impactful projects that lack existing funding.

Overview

Note: For application re-submission, please include an updated revision statement. Only one re-submission per application is permitted. Purpose To support innovative and novel investigations in Primary Immunodeficiency focusing on translational research leading to meaningful clinical application. To advance the growing knowledge of genotype-phenotype correlations and gain a better understanding of the underlying mechanisms of immune function and dysfunction. To support research that will lead to advancement in clinical recognition, diagnostic tools, and innovative therapies that will impact overall health outcomes and improve the quality of life of those affected by Primary Immunodeficiency. To date, over 500 specific genetic defects have been identified, which have not only helped advance new therapies, but have also been instrumental in advancing our understanding of immunology. It is estimated that as many as 10 million people, if not more, are living with Primary Immunodeficiency worldwide. As such, it is crucial to support research that will bridge basic scientific discoveries to the development of clinical applications that will impact overall health outcomes. Advancing research that enhances our understanding of the immune system represents one of the single greatest strategies that biomedical science has to offer to identify new therapies and will greatly benefit those living with diagnosed Primary Immunodeficiencies as well as the millions of people that remain undiagnosed. Award Information The number of awards per cycle will be dependent on the strength and merit of applications received and the availability of funds. Individual awards may total up to $250,000 over a two-year period. Funds are not to exceed $125,000 per year per project. Total funds will only support direct costs and cannot be used for institutional overhead. JMF reserves the right to reduce the award amount for any application. To date, a total of 23 grants have been awarded throughout 12 grant cycles.

Eligibility

You can learn more about this opportunity by visiting the funder's website. Novel Primary Immunodeficiency defectsInnovative approaches to early diagnosis - Novel therapeutic strategiesTranslational impact on patient health (i.e., how a patient will benefit)Reach of the proposed project (i.e., how many patients might benefit)Projects that currently do not have funding and would be otherwise difficult to advance without this awardThe Jeffrey Modell Foundation encourages all international and U.S. investigators with the appropriate knowledge and research skill level to apply for this grant. Applications submitted by investigators with vast expertise in Primary Immunodeficiency, as well as young investigators with robust scientific merit will be considered. JMF encourages investigators who are not currently receiving funding from the National Institutes of Health to apply. Only one active grant per  investigator is permitted at a time.