Immunology and Immunotherapy SMRT Grant

The Immunology and Immunotherapy SMRT Grant by Pacific Biosciences aims to enhance research through advanced sequencing technologies. This grant offers free sequencing to support innovative projects in immunology and immunotherapy, encouraging researchers to apply their findings to better understand the immune system and develop new therapies. With the opportunity to utilize highly accurate long-read sequencing, winners will gain access to state-of-the-art technology that can accommodate multiple libraries, enhancing their research outcomes significantly.

Note: The Grant Program begins on Monday, December 1st, 2025, at 9:00 a.m. Pacific Daylight Time and ends on Friday, January 16th, 2026, at 5:00 p.m. Pacific Daylight Time; entries must be submitted during that period to be eligible
Could your research benefit from highly accurate long-read sequencing?
Apply to win free sequencing to enhance and promote your immunology and immunotherapy research.
Could your research benefit from highly accurate long-read sequencing? Apply for this SMRT Grant! With highly accurate long HiFi reads, you can elevate your immunology and immunotherapy research to the next level.
Tell us in 100 words or less how PacBio HiFi ProfilAIR sequencing in your project will contribute to understanding the immune system and/or developing therapies for a chance to be one of three winners of sequencing on two Vega SMRT Cells. ProfilAIR can accommodate up to 72 chain-specific libraries (choose from IgM, IgG, IgK, IgL, TRB and TRA) per 2 SMRT Cells.
For example, this translates to analysis of IgG, TRB and TRA for up to 24 samples.
ProfilAIR
The first RNA-based assay for profiling complete immune receptor transcripts
Complete set of pre- and post-processing HiFi reads of IG/TCR transcripts, with sample-level data quality control reports.
Fully curated transcript data with:

• Allele-level annotation of V, D, J, and C genes (using inferred germlines)
• Isotype, subisotype, and C gene allele-level assignment
• Clone assignment
• Annotation of CDRs, FWRs, and 5’ untranslated regions
• Isotype-, subisotype-, and allele-level V, D, and J gene usage profiles
• We encourage scientists of any level to apply.