End Allergies Together Research Grants

End Allergies Together Research Grants

Funder: End Allergies Together Inc (MA, US)

Website: endallergiestogether.com

Organization Type: 501(c)(3) non-profit organization

Mission & Focus

E•A•T is solely focused on funding research to accelerate the most promising ideas in food allergy research toward clinical testing and expansion of shorter-term treatments and longer-term solutions.

Research Goals

• Advance scientific and medical research to accelerate diagnostics, treatments, cures and prevention of food allergy
• Understand underlying immune mechanisms
• Determine genetic and epigenetic factors of food allergy prevalence
• Discover role of microbiome in food allergy
• Understand basic biology to surface key targets for breakthrough treatments
• Identify and accelerate short-term therapies to increase quality of life in patient subsets

What They Fund

Research studies in the following focus areas:
• Biomarkers: Research to develop better diagnostic markers for food allergies and eosinophilic esophagitis (EoE)
• Microbiome: Studies on the role of gut microbiota in food allergy prevention and treatment
• Oral Immunotherapy (OIT): Research to improve safety and efficacy of OIT treatments
• Prevention: Studies on preventing allergic sensitization
• Eosinophilic Esophagitis (EoE): Research on diagnosis and treatment of EoE
• Basic Science: Fundamental research on food allergy mechanisms, cellular landscape, allergen sensing, immune responses, and clinical/translational applications

What They Do NOT Fund

• Educational programming
• Publications
• Advocacy related efforts
• Operations for treatment centers
• Other food allergy related initiatives outside of research

Funding Process

Objective Funding Approach: E•A•T's Medical Advisory Board uses an objective grant process to recommend funding allocations for research studies. The Medical Advisory Board is comprised of highly knowledgeable scientists and physicians who are leaders in the field but not conducting their own studies.

Geographic Scope

No geographic restrictions indicated; studies funded include researchers from:
• United States (Children's Hospital of Philadelphia, Stanford University, University of Chicago, Boston Children's Hospital, Cincinnati Children's Hospital, National Jewish Denver, King's College London institutions, Broad Institute of MIT and Harvard, Yale School of Medicine)
• United Kingdom (Imperial College London)

Contact Information

• Email: Research@EndAllergiesTogether.com
• Address: P.O. Box 786, Fairfield, CT 06824
• General Email: info@endallergiestogether.com

Recently Funded Studies (as of May 23, 2016)

1. 'Molecular Gene Expression During Allergic Reactions to Food: Identifying Signatures Which Correlate with Severity of Reaction' - Jonathan M. Spergel, MD, PhD (Children's Hospital of Philadelphia) and Paul J. Turner, FRACP PhD (Imperial College London) 2. 'Characterization of Prebiotic Dietary Fibers to Prevent or Treat Food Allergy' - Cathryn R. Nagler, PhD (University of Chicago) 3. 'Improving Safety for the Food Allergy-Asthma Syndrome' - Sharon Chinthrajah, MD and Kari Nadeau, MD, PhD (Stanford University)

Additional Funded Research Areas

• 'Developing Non-Invasive Biomarkers for Eosinophilic Esophagitis by Genetic Testing and Molecular Profiling of the Buccal Mucosa' - Marc Rothenberg, MD, PhD (Cincinnati Children's Hospital)
• 'Open Label Phase I Trial to Evaluate Safety and Efficacy of Fecal Microbiota Transplantation in Peanut Allergic Patients' - Rima Rachid, MD (Boston Children's Hospital)
• 'SEAL (Stopping Atopic Dermatitis and Allergy) Study: Prevent the allergic march by enhancing the skin barrier' - Kari Nadeau, MD, PhD (Stanford University), Gideon Lack, MD and Helen Brough, MD, and Susan Chan, MD (King's College London), Donald Leung, MD, PhD (National Jewish Denver)
• 'Use of Esophageal String Test to Understand Symptoms, Inflammation and Function in EoE' - Calies Menard-Katcher, MD, MSCS (Children's Hospital of Colorado) and Amanda Muir, MD (Children's Hospital of Philadelphia)
• Food Allergy Science Initiative (FASI) - centered at the Broad Institute of MIT and Harvard with Yale School of Medicine