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Crazy 8 Initiative Grant Program on Pediatric Brain Tumors

Alexs Lemonade Stand Foundation

Funding Amount

US $3,000,000 - US $5,000,000

Deadline

Deadline not published

Grant Type

Foundation

Overview

The Crazy 8 Initiative Grant Program, established by Alex’s Lemonade Stand Foundation, aims to advance pediatric brain tumor treatments through collaborative research efforts. This program encourages partnerships between multiple institutions and emphasizes the inclusion of patient advocates. With a budget range of $3-5 million over four years, the initiative seeks innovative proposals that focus on improving outcomes for children and adolescents affected by these tumors, contributing significantly to the fight against childhood cancer.

About Alex’s Lemonade Stand Foundation (ALSF)
Alex's Lemonade Stand Foundation (ALSF) emerged from the front yard lemonade stand of 4-year-old Alexandra “Alex” Scott, who was fighting cancer and wanted to raise money to find cures for all children with cancer. Her spirit and determination inspired others to support her cause, and when she passed away at the age of 8, she had raised $1 million. Since then, the Foundation bearing her name has evolved into a national fundraising movement. Today, ALSF is one of the leading funders of pediatric cancer research in the U.S. and Canada, funding more than 1,500 research projects and providing programs to families affected by childhood cancer. ALSF is also the only childhood cancer research organization that has been given the NCI peer-reviewed funder designation for rigorous selection of research grants. The mission of ALSF is to change the lives of children with cancer through funding impactful research, raising awareness, supporting families, and empowering everyone to help cure childhood cancer.
Program Description
This ALSF Crazy 8 RFA focuses on developing and enhancing pediatric brain tumor treatments. The focus must be on pediatric/adolescent brain tumors and should be a consortium of two or more institutions with different areas of research collaborating to integrate their expertise. It is strongly encouraged to have a patient advocate on the team.
Budget
Depending on the type of project and the size of the team, the requested budget should be in the range of $3-5 million USD over four years.

What Alexs Lemonade Stand Foundation actually gave

Source: IRS Form 990, 2025

Grants in 2025
58
Total given
$19.14M
Median grant
$162K
Range
$6,000–$2.32M
  • By dollars: California 19%, Massachusetts 16%, Pennsylvania 15%. Top recipient cities: Boston, MA; New York, NY; Philadelphia, PA.
  • 0% of grants with a stated purpose were for general or operating support.
  • 28% of recipients were new grantees, not repeat recipients.

Example grants

  • Children's Hospital of Philadelphia · Philadelphia, PA

    Pediatric cancer research

    $2.32M

  • Dana-Farber Cancer Institute · Boston, MA

    Pediatric cancer research

    $2.25M

  • University of California San Francisco · San Francisco, CA

    Pediatric cancer research

    $1.93M

  • St Jude Children's Research Hospital · Memphis, TN

    Pediatric cancer research

    $1.47M

  • Baylor College of Medicine · Houston, TX

    Pediatric cancer research

    $1.42M

IRS Form 990, 2025. Amounts as reported by the funder. Full 990 history →

Focus Areas & Funding Uses

Fields of Work

  • Cancer
  • Science research

Categories

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