CDKL5 Pilot Grant Program

CDKL5 Pilot Grant Program

Status: ACTIVE
Funder: University of Pennsylvania’s School of Medicine: Orphan Disease Center (ODC)
Amount: US $150,000
Last Updated: March 21, 2026

Summary

Overview

Note: All applicants must first submit a Letter of Interest (LOI) (indicated above as Letter of Inquiry) to be reviewed for consideration of a full application submission. Full applications will be by invitation only following LOI review. The Orphan Disease Center The Orphan Disease Center is part of the University of Pennsylvania’s School of Medicine. Mission The Orphan Disease Center will develop transformative therapies using platform technologies that can be deployed across multiple rare diseases. We will emphasize disorders with substantial unmet need independent of their incidence and will strive to assure access to patients of all populations. Through our grants, Programs of Excellence, JumpStart programs, and a number of new initiatives, the ODC seeks to drive therapeutic development for rare diseases. We help identify and fund the most promising therapeutics while also tackling obstacles present in rare disease drug development. CDKL5 Pilot Grant Program The ODC and Loulou Foundation CDKL5 Pilot Grant Program provides a one‐year grant for $150,000.00 (total cost) to support research related to CDKL5 Deficiency Disorder (CDD). The number of awards is not fixed, and may vary. We are seeking grant applications that progress the discovery or development of treatments and/or cures for CDKL5 Deficiency Disorder. Because many gaps remain in our understanding of the biology of CDKL5 and its role in neurological development and function, applications that address such gaps in basic science are welcome, provided that they are tethered to the development of a potential therapy.

Eligibility

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