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ARPA-H PRINT Program (Personalized Regenerative Immunocompetent Nanotechnology Tissue)

HANSJORG WYSS INSTITUTE FOR BIOLOGICALLY

Foundation Grants for Science Research
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Funding Amount

Up to $25,000,000

Deadline

Rolling / Open

Grant Type

foundation

Overview

ARPA-H PRINT Program Overview

Funder: Advanced Research Projects Agency for Health (ARPA-H)

Award Amount: Up to $25 million over 5 years

Geographic Scope: United States (federal funding)

Focus Areas:

  • Regenerative medicine

  • Tissue engineering

  • Organ engineering

  • Immunoengineering

  • Synthetic biology

  • 3D bioprinting

  • Cell differentiation technologies

  • Vascularized tissue construction

  • Xenotransplantation and organ replacement

    • Program Description:
    The ImPLANT project (Immunoshielded Printed Liver Assist NeoOrgan for Transplant) is a highly collaborative, multi-institutional initiative funded by ARPA-H's PRINT program. The project aims to engineer the first off-the-shelf, universal, transplant-ready liver graft to address liver failure in over 500 million patients worldwide.

    Key Components:

  • Development of synthetic biology-based gene circuits in human induced pluripotent stem cells (iPSCs)

  • Immunoengineering to enable immune rejection evasion

  • Integration of bioreactor and 3D printing technologies

  • Testing in humanized animal models

  • Development of manufacturing standards for clinical application

    • Institutions Involved:

  • Wyss Institute at Harvard University (Lead)

  • MIT

  • University of Colorado Boulder

  • Columbia University

    • Project Leadership:

  • Principal Investigator: Christopher Chen, M.D., Ph.D. (Wyss Institute Core Faculty, Boston University)

  • Co-investigators include Ron Weiss (MIT), Sangeeta Bhatia (MIT), Jason Burdick (University of Colorado Boulder), Megan Sykes (Columbia University), David Sachs (Columbia University), and Gordana Vunjak-Novakovic (Columbia University)

    • Contact: Award Number D25AC00322-00

    Focus Areas & Funding Uses

    Fields of Work

    science-research

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