Aptadel Therapeutics Grant - ADEL-101 (Second Commitment)
Funding Amount
$680,000
Deadline
Deadline not published
Grant Type
Foundation
Deadline history & next window
- Cycle
- One-time opportunity
- Tracked since
- April 2026
Source: the cycle recorded on this listing. Confirm dates with the funder.
Overview
Aptadel Therapeutics Partnership Grant
Geographic Scope: Barcelona, Spain
Background
This is a follow-up commitment to advance ADEL-101, an aptamer drug conjugate (ApDC) targeting EWSR1::FLI1 (Type 1) fusion in Ewing sarcoma. The initial $500,000 grant supported preclinical development; this additional $680,000 addresses biodistribution challenges identified in mouse models.
Focus Areas
- Drug: ADEL-101 (aptamer drug conjugate)
- Target: EWSR1::FLI1 fusion oncogene in Ewing sarcoma
- Challenge: Previous studies showed rapid kidney clearance; new strategy aims to improve biodistribution by increasing compound size to prevent renal filtering
- Timeline: 15-month development period to improve in vivo proof-of-principle
- Goal: Enhanced tumor targeting and therapeutic activity leading to clinical translation
Mechanism of Action
ADEL-101 uses an RNA aptamer that binds to epHA2 (marker on Ewing sarcoma cells) and delivers siRNA to silence the EWSR1::FLI1 fusion gene.
What Little Warrior Foundation Inc actually gave
Source: IRS Form 990, 2025
- Grants in 2025
- 8
- Total given
- $795K
- Median grant
- $66K
- Range
- $20K–$263K
- By dollars: Massachusetts 43%, New York 22%, Florida 13%. Top recipient cities: Boston, MA; Braintree, MA; New York, NY.
- 0% of grants with a stated purpose were for general or operating support.
Example grants
Beat Childhood Cancer DFMO · Braintree, MA
Medical research
$263K
Memorial Sloan Kettering Cancer Center · New York, NY
Medical research
$175K
Nicklaus Children's Health System · Miami, FL
Medical research
$100K
Cleveland Clinic Foundation · Westlake, OH
Medical research
$72K
Boston Children's Hospital · Boston, MA
Medical research
$61K
Focus Areas & Funding Uses
Fields of Work
- Cancer
- Science research
Categories
Browse similar grants by category
Related Grants
Open grants from this funder and similar programs
Beat Childhood Cancer Foundation - Multi-Trial Grant (DFMO Studies)
Little Warrior Foundation Inc
Amount
$700,000
Deadline
Deadline not published
Functional Precision Medicine Emergency Grant (Dr. Maggie Fader, Nicklaus Children's)
Little Warrior Foundation Inc
Amount
$100,000
Deadline
Deadline not published
University of Virginia ETS Fusion Inhibitor Grant (Dr. John Bushweller)
Little Warrior Foundation Inc
Amount
$130,000
Deadline
Deadline not published
Aptadel Therapeutics Grant - ADEL-101 (Initial Award)
Little Warrior Foundation Inc
Amount
$500,000
Deadline
Deadline not published
Glioblastoma Therapeutics Network (GTN) (U19 Clinical Trial Required)
National Institutes of Health
Amount
Up to $700K
Deadline
January 11, 2027
ACMS Foundation Investigator Research Award
American College of Mohs Surgery Inc
Amount
$20K – $40K
Deadline
Expected ~February
Based on past cycles
Ready to apply for Aptadel Therapeutics Grant - ADEL-101 (Second Commitment)?
Grantable helps you assess fit, draft narratives, and track deadlines — so you can submit stronger applications, faster.
You found Aptadel Therapeutics Grant - ADEL-101 (Second Commitment). Now let's win it.