Aptadel Therapeutics Grant - ADEL-101 (Second Commitment)
Funding Amount
$680,000
Deadline
Deadline not published
Grant Type
Foundation
Deadline history & next window
- Cycle
- One-time opportunity
- Tracked since
- April 2026
Source: the cycle recorded on this listing. Confirm dates with the funder.
Overview
Aptadel Therapeutics Partnership Grant
Geographic Scope: Barcelona, Spain
Background
This is a follow-up commitment to advance ADEL-101, an aptamer drug conjugate (ApDC) targeting EWSR1::FLI1 (Type 1) fusion in Ewing sarcoma. The initial $500,000 grant supported preclinical development; this additional $680,000 addresses biodistribution challenges identified in mouse models.
Focus Areas
- Drug: ADEL-101 (aptamer drug conjugate)
- Target: EWSR1::FLI1 fusion oncogene in Ewing sarcoma
- Challenge: Previous studies showed rapid kidney clearance; new strategy aims to improve biodistribution by increasing compound size to prevent renal filtering
- Timeline: 15-month development period to improve in vivo proof-of-principle
- Goal: Enhanced tumor targeting and therapeutic activity leading to clinical translation
Mechanism of Action
ADEL-101 uses an RNA aptamer that binds to epHA2 (marker on Ewing sarcoma cells) and delivers siRNA to silence the EWSR1::FLI1 fusion gene.
What Little Warrior Foundation Inc actually gave
Source: IRS Form 990, 2024
- Grants in 2024
- 3
- Total given
- $251K
- Median grant
- $43K
- Range
- $33K–$175K
- By dollars: Massachusetts 70%, Virginia 30%. Top recipient cities: Charlottesville, VA; Braintree, MA.
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Focus Areas & Funding Uses
Fields of Work
- Cancer
- Science research
Categories
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