Annual Grants

Annual Grants Program

Geographic Scope: National and international

Focus Areas:

• Clinical trials of new potential therapies
• Correlative science (evaluation of how and why potential new therapies work or don't work in clinical trials)
• Basic biology of osteosarcoma cancer and its metastasis
• Translational research (pre-clinical research bridging laboratory findings to clinical application)
• High-risk/high-impact research (bold, pioneering ideas that challenge traditional approaches)

Award Amounts:

• Translational/correlative grants: Up to $500,000
• Clinical trials: Up to $800,000
• High-risk/high-impact studies: Variable (e.g., $100,000)

Eligibility:

• Researchers with osteosarcoma research proposals
• Studies focused on developing better treatments and ultimately a cure for osteosarcoma
• Both preclinical and clinical research welcome

Application Process:

• Two-stage annual grant cycle
• Letters of Intent (LOI) due mid-November each year
• Full applications follow LOI acceptance
• Expert review committee evaluates submissions
• Awards announced in spring

What They Fund:

• Research using new technologies
• Projects with clear timeline to clinical testing
• Immunotherapy approaches
• CAR-T cell therapy developments
• Studies on osteosarcoma metastasis prevention
• Genomics and molecular biology research

What They Don't Fund:

• Not explicitly stated

Background:

• OSI launched in 2017 and has awarded over $5 million to osteosarcoma research since inception
• Standard treatments for osteosarcoma have not changed in 40 years
• OSI is a leading funder of osteosarcoma research
• Strategic Advisory Board includes Nobel Prize recipient and experts across multiple disciplines
• Starting in 2019, OSI awards grants in three main categories; added high-risk/high-impact category in 2023

Contact Information:

• Address: 3963 Maple Avenue Suite 390, Dallas, TX 75219
• Phone: 972.903.8408
• Email: info@osinst.org
• Website: osinst.org

Application Process

Two-Stage Annual Grant Cycle:

1. Stage One: Letter of Intent (LOI)
   • LOI deadline: Mid-November each year
   • LOI submissions outline the proposed research
2. Stage Two: Full Application
   • Invited after LOI acceptance
   • Full applications required for selected LOI submissions

Expert Review:

• Submissions evaluated by OSI's expert review committee
• Committee provides feedback to applicants, even those not selected
• Feedback includes specific advice and direction for improvement

Award Announcements:

• Grants announced in spring (typically June)

Post-Award Requirements:

• Principal Investigators must provide progress reports every six months
• Reports shared with OSI Strategic Advisory Board
• Results made available to the public upon completion
• Emphasis on transparency and accountability

Additional Support:

• OSI offers invaluable feedback, advice, and guidance to researchers
• $20,000 spot/ad hoc grants available to help researchers elevate work for future resubmission
• Researchers receive mentorship from Nobel Prize recipient and expert board members