2026 Pilot Research Award - Targeting GBP-1 to Overcome Chemotherapy Resistance and Immune Suppression in Ovarian Cancer
Funding Amount
$25,000
Deadline
Rolling / Open
Grant Type
foundation
Overview
2026 Pilot Research Award - Targeting GBP-1 to Overcome Chemotherapy Resistance and Immune Suppression in Ovarian Cancer
Funder: Sherie Hildreth Ovarian Cancer (SHOC) Foundation
Award Amount: $25,000
Focus Area: Mechanistic and translational research on chemotherapy resistance and immune suppression
Project Description
This pilot award provides catalytic support for mechanistic and translational research examining the role of Guanylate-Binding Protein 1 (GBP-1) in ovarian cancer progression, chemotherapy resistance, and immune suppression. Using complementary murine models and human tumor analyses, this project seeks to define how GBP-1 shapes the tumor microenvironment and to evaluate a first-in-class GBP-1 inhibitor as a potential therapeutic strategy. The award provides key experiments that will strengthen the foundation for future external funding and novel combination therapies.- Dr. Sanjay Malhotra | OHSU Knight Cancer Institute
- Dr. Thomas Duhen | Providence Portland Cancer Institute
- Dr. Christopher Darus | Providence Portland Cancer Institute
Investigators
Geographic Scope
Oregon (US)Mission Alignment
The SHOC Foundation supports diverse portfolios of ovarian cancer research spanning early detection, novel therapeutics, survivorship, and equity. The foundation invests in innovative science, translational discovery, and supports the next generation of women investigators.Focus Areas & Funding Uses
Fields of Work
cancerscience-research
Categories
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