The Colonna Family Foundation

Enterprise Holdings Foundation

Saint Louis, MO

Enterprise Holdings Foundation supports nonprofits in health, education, arts, disaster relief, reforestation, hunger relief, and community equity, with an emphasis on organizations actively supported by Enterprise employees and their families. Its reported grants range widely: 2024 giving averaged about $7,700 across 9,499 grants, while the foundation also offers awards of up to $40,000; it supports communities where Enterprise operates worldwide. Unsolicited requests are accepted at any time, but eligible applications must be submitted by an Enterprise team member or their spouse or domestic partner on behalf of a nonprofit they actively support.

Aetna Foundation Inc

Hartford, CT

Aetna Foundation supported health and wellness, access to health care, and related community needs; its 2021 grants ranged from $5,000 to $1 million, with a median of $40,000, and went to organizations across multiple states, especially in D.C. and Connecticut. Its 2021 filing was marked final, so it appears to have ended or be winding down grantmaking; that filing said there were no restrictions on who could apply and pointed applicants to its website for application materials.

McKesson Foundation Inc

Dallas, TX

McKesson Foundation supports healthcare access across the U.S. and Canada, focusing on cancer, healthcare workforce training, and emergency response, especially for vulnerable communities; local priorities include Atlanta, Columbus, Dallas-Fort Worth, Houston, Memphis, Montreal, Richmond, and Toronto. Its 2025 grants ranged from $10,000 to $2.47 million, with a median of $100,000. Its filing says it does not accept unsolicited requests, while its current website describes online applications: up to $25,000 year-round and larger requests from February 1 through April 30.

Duke Energy Foundation

Charlotte, NC

The Duke Energy Foundation funds workforce development, local economic development and recovery, disaster resilience, conservation, and economic opportunity in communities across North Carolina, South Carolina, Florida, Ohio, Kentucky, and Indiana. It reports more than $30 million in annual charitable grants; awards vary widely, with a 2024 median of $25,000, and applications of $20,000 or less are accepted on a rolling basis. Applicants should contact their local Foundation representative before applying.

Dollar Bank Foundation

Pittsburgh, PA

Dollar Bank Foundation funds community and economic development, workforce development, health and human services, arts, education, diversity, equity and inclusion, and veterans’ programs, mainly in western Pennsylvania, northeast Ohio, the Cumberland Narrows area of Maryland, and Hampton Roads, Virginia. In 2025, its grants ranged from $250 to $1 million, with a median of $5,000. Its 2024 filing describes a case-by-case written request process and says it does not limit giving to preselected organizations; the request portal is closed for the remainder of 2026.

Equitrans Midstream Foundation

Canonsburg, PA

The Equitrans Midstream Foundation funded community development, education, and environmental work in communities where the company operated, including in West Virginia, Pennsylvania, and Virginia; recent grants ranged from $50,000 to $153,000 among the examples listed. It accepted requests only from preselected organizations, not unsolicited requests, and appears to have wound down after merging with EQT Foundation in 2025.

Bristol-Myers Squibb Foundation Inc

Princeton, NJ

The Bristol-Myers Squibb Foundation supports health-access initiatives for disproportionately affected populations, including cancer, blood disorders, brain health, and clinical-trial participation, in the United States and internationally. In 2024, its median grant was $134,090, though awards varied widely; it says application materials are available upon request and advises organizations to contact it about the process, but does not state whether unsolicited requests are accepted.

Richard King Mellon Foundation

Ligonier, PA

The Richard King Mellon Foundation funds conservation and environmental restoration, Southwestern Pennsylvania economic development and mobility, health and well-being, and organizational effectiveness, with most giving focused on Pennsylvania and some environmental grants elsewhere. Its 2024 grants ranged from $2,000 to $10 million, with a median of $220,000. It accepts applications through its General Application for proposals aligned with its strategic plan; Economic Mobility applications are accepted on a rolling basis.

Upmc Group

Pittsburgh, PA

UPMC GROUP supports healthcare, education, and research, including medical research, community health, and general support for universities and health-related organizations. Its 2025 grants ranged from $5,180 to $176.2 million, with a median of $12,500; nearly all grant dollars went to Pennsylvania recipients. UPMC in Central Pa. accepts event sponsorship applications, but the profile does not state whether UPMC GROUP accepts unsolicited grant requests.

The United Way of Southwestern

Pittsburgh, PA

The United Way of Southwestern Pennsylvania funds work addressing basic needs, school and life success, and financial stability, including food access, housing, education, employment, and financial support. It invests mainly in Allegheny, Armstrong, Butler, Fayette, and Westmoreland counties; its 2025 grants had a median award of about $15,900, with amounts ranging from about $5,000 to $496,000.

Mutual of America Foundation

New York, NY

The Grable Foundation

Pittsburgh, PA

The Grable Foundation funds early learning, public education, out-of-school programs, and community resources that improve children’s lives, primarily in the Pittsburgh region. Its 2024 grants ranged from $2,000 to $1 million, with a median of $20,000. It accepts proposals by letter and has no special application form; requests should align with its fields of interest.