The Church Mouse Thrift Shop Inc

The Berkeley Hall Charitable

Bluffton, SC

To improve the quality of life of bluffton, sc community residents and residents of neighboring beaufort county, especially those who are most vulnerable, promote philanthropy, and act as an effective steward of charitable funds.

Food Lion Feeds Charitable Foundati

Salisbury, NC

The foundation supports hunger relief across Food Lion’s 10-state operating area, including efforts to combat childhood food insecurity, provide fresh food, build feeding partners’ capacity, and offer nutrition education. It awards grants through multiple cycles, but available information does not establish a typical award size; applicants must generally be affiliated with Feeding America or United Way, and the foundation accepts applications online.

Wexford Foundation

Hilton Head Island, SC

The Wexford Foundation supports local South Carolina nonprofits addressing humanitarian needs, including food access, health, child care and education, shelter, and housing. In 2025, its 29 grants ranged from $6,000 to $145,000, with a median of $16,500; whether it accepts unsolicited requests is not stated.

Community Foundation of the Lowcountry

Hilton Head Island, SC

The Community Foundation of the Lowcountry funds nonprofits working in areas such as education, health, human services, arts, environment, animal welfare, and community development in Beaufort, Colleton, Hampton, and Jasper Counties, South Carolina; its Impact Grants have a narrower service area. Grants vary widely: the 2025 median was $15,000, with awards from $5,000 to over $1.2 million. It accepts requests through grant programs that begin with a Grant Inquiry Form.

United Way of the Lowcountry

Beaufort, SC

To educate and encourage our community to make investments that enable individuals and families to achieve self-sufficiency.

The Bargain Box

Hilton Head Island, SC

The Bargain Box funds Beaufort County, South Carolina, nonprofits working in areas such as education and youth, health and safety, hunger and housing, and recreation. Recent grants ranged from $7,500 to $42,500, with a median of $11,000. It accepts unsolicited requests through its official application, submitted in both hardcopy and electronic form.

Breedlove Foundation Im 020120186528

Hendersonville, NC

Ekedahl Foundation

Hilton Head Island, SC

David W Ellis Family Foundation

Hilton Head, SC

Hickory Fund Inc

Milwaukee, WI

Hickory Fund supports programs improving life for people with intellectual and physical disabilities, as well as work addressing food insecurity, veterans’ needs, and underserved youth, primarily in Wisconsin and South Carolina. Its 2025 grants ranged from $3,000 to $50,000, with a median of $15,000. It accepts Letters of Inquiry through an online process; selected organizations may be invited to submit a full application.

Coastal Community Foundation of South

N Charleston, SC

The Coastal Community Foundation of South Carolina funds nonprofits through competitive grants for areas including education, health, community development, arts, and human needs. Its 2024 grants had a median of $16,500, with awards ranging from $5,057 to $2.3 million, across nine coastal South Carolina counties. It accepts applications only for listed competitive programs, through its online portal.

Duke Energy Foundation

Charlotte, NC

The Duke Energy Foundation funds workforce development, local economic development and recovery, disaster resilience, conservation, and economic opportunity in communities across North Carolina, South Carolina, Florida, Ohio, Kentucky, and Indiana. It reports more than $30 million in annual charitable grants; awards vary widely, with a 2024 median of $25,000, and applications of $20,000 or less are accepted on a rolling basis. Applicants should contact their local Foundation representative before applying.