The Bob and Karen Wortham Charitable Fou

Bristol-Myers Squibb Foundation Inc

Princeton, NJ

The Bristol-Myers Squibb Foundation supports health access and stronger health systems, with a focus on adult and pediatric cancers, blood disorders, brain health, and clinical-trial participation in the United States, Brazil, India, and ten Sub-Saharan African countries. In 2024, its median grant was about $134,000, though awards varied widely; it does not state whether it accepts unsolicited requests, and advises prospective applicants to contact the Foundation about its process.

Greater Houston Community Foundation

Houston, TX

The Foundation makes grants through donor-advised and other donor-established funds for public benefit, human services, education, and health, including initiatives addressing economic mobility and poverty in Harris County. In 2024, its median grant was $25,000; it serves Greater Houston, while grants also go to recipients elsewhere in Texas and beyond. It does not accept proposals for the upcoming High-Impact Grantmaking cycle and plans to invite selected organizations or collaboratives to apply.

Communities Foundation of Texas Inc

Dallas, TX

Communities Foundation of Texas funds a broad range of community needs, including health, education, housing, and community development, primarily in North Texas and across Texas. Its 2025 grants had a median of about $18,800, though amounts varied widely; nearly all opportunities are by invitation, with some specific programs open for applications.

BNSF Railway Foundation

Fort Worth, TX

The BNSF Railway Foundation funds civic, cultural, education, health and human services, environmental, and youth programs, including operating costs and specific projects. Its 2025 median grant was $2,500, though awards ranged from $100 to $500,000; it supports eligible organizations serving communities near BNSF rail lines across its 28 operating states. The foundation provides an online application process, but whether it accepts unsolicited requests is not stated.

Baker Hughes Foundation

Houston, TX

Community Foundation of North Texas (Tax

Fort Worth, TX

The foundation supports nonprofits and community projects in areas including animal welfare, nonprofit capacity building, first responders, land conservation, neighborhood development, opportunity and access, and scholarships. In 2024, grants ranged from $5,100 to $1.5 million, with a median of $14,250; its service area covers 11 North Texas counties. It accepts applications for some competitive grant programs through its online portal, but donor-advised grants are not open to nonprofit applications.

Michael & Susan Dell Foundation

Austin, TX

The Michael & Susan Dell Foundation funds education, health, jobs and livelihoods, and family economic stability, with its deepest U.S. focus in Texas and additional work across the U.S. and internationally. In 2024 it awarded 835 grants totaling about $164.6 million; grants ranged from $75 to $50 million, with a median of $19,324. It accepts unsolicited requests through its online application process.

American Heart Association Inc

Dallas, TX

The American Heart Association funds basic, clinical, behavioral, translational and population research on cardiovascular, cerebrovascular and brain health, along with research training and education programs. In 2025 it awarded 833 grants totaling about $198 million; amounts ranged from $5,000 to nearly $9.93 million, with a median of $20,000. Research awards are for eligible U.S.-based nonprofit institutions, and the profile describes a formal proposal process but does not state whether unsolicited requests are accepted.

Laura and John Arnold Foundation

Houston, TX

Arnold Ventures funds evidence-based research, policy analysis, and reforms in areas including criminal justice, health care, education, higher education, public finance, and infrastructure, with a focus on improving outcomes for Americans. Its 2024 grants ranged from $685 to $12.5 million, with a median of $122,776. It does not accept unsolicited requests; most proposals come through direct outreach, with periodic RFPs.

The Dallas Foundation

Dallas, TX

The Dallas Foundation funds nonprofit work in Greater Dallas, with a current emphasis on early childhood and family well-being and other areas including economic mobility, homelessness, and youth mental health. In 2024, grants ranged from $5,020 to $7.85 million, with a median of $25,000; applicants generally must serve Dallas County residents. It accepts applications through its online portal when a grant cycle is open, but reports no open opportunities at this time.

Petco Love

San Antonio, TX

Petco Love funds animal-welfare organizations working on adoption, shelter-pet lifesaving, veterinary care, spay/neuter, emergency treatment, and reuniting lost pets with families, with grantmaking nationwide. In 2025, its grants ranged from $5,004 to $1,501,620, with a median of $13,370. It accepts applications for some opportunities through its Partner Portal during designated windows; some cycles are invitation-only.