South Texas Blood & Tissue Center

80-20 Foundation

San Antonio, TX

The 80-20 Foundation supports public charities advancing San Antonio’s workforce, entrepreneurs, and quality of life, including programs in technology, youth development, arts and culture, and urban spaces. Its 2024 grants ranged from $2,000 to $836,000, with a median grant of $25,000, and its giving is focused mainly on San Antonio. It accepts applications through an online grant application; no deadline is listed.

The Tobin Endowment

San Antonio, TX

The Tobin Endowment supports nonprofit arts and cultural organizations, including theater, opera, and historic preservation, as well as civic, educational, and other charitable causes, primarily in the San Antonio area. Its 2024 grants ranged from $9,000 to $1,792,457, with a median of $60,000. It accepts written requests from eligible 501(c)(3) organizations; no formal deadlines are stated.

Sam and Helga Feldman Foundation

San Antonio, TX

The foundation supports organizations working in disability services, education, health, animal welfare, and community programs, with most 2025 grant dollars going to Texas and New York. Grants ranged from $2,000 to $350,000, with a median of $10,000. It accepts applications beyond a preselected list of organizations; no deadline is stated.

Friends of Bexar County Child Welfare Board Inc

San Antonio, TX

Mission is to serve as a proactive voice for all abused, neglected, and at risk children in Bexar County, Texas and to augment the services that are delivered to them through advocacy and fundraising

Communities Foundation of Texas Inc

Dallas, TX

Communities Foundation of Texas funds a broad range of community needs, including health, education, housing, and community development, primarily in North Texas and across Texas. Its 2025 grants had a median of about $18,800, though amounts varied widely; nearly all opportunities are by invitation, with some specific programs open for applications.

Greater Houston Community Foundation

Houston, TX

The Foundation makes grants through donor-advised and other donor-established funds for public benefit, human services, education, and health, including initiatives addressing economic mobility and poverty in Harris County. In 2024, its median grant was $25,000; it serves Greater Houston, while grants also go to recipients elsewhere in Texas and beyond. It does not accept proposals for the upcoming High-Impact Grantmaking cycle and plans to invite selected organizations or collaboratives to apply.

Baker Hughes Foundation

Houston, TX

BNSF Railway Foundation

Fort Worth, TX

The BNSF Railway Foundation funds civic, cultural, education, health and human services, environmental, and youth programs, including operating costs and specific projects. Its 2025 median grant was $2,500, though awards ranged from $100 to $500,000; it supports eligible organizations serving communities near BNSF rail lines across its 28 operating states. The foundation provides an online application process, but whether it accepts unsolicited requests is not stated.

Community Foundation of North Texas (Tax

Fort Worth, TX

The foundation supports nonprofits and community projects in areas including animal welfare, nonprofit capacity building, first responders, land conservation, neighborhood development, opportunity and access, and scholarships. In 2024, grants ranged from $5,100 to $1.5 million, with a median of $14,250; its service area covers 11 North Texas counties. It accepts applications for some competitive grant programs through its online portal, but donor-advised grants are not open to nonprofit applications.

Michael & Susan Dell Foundation

Austin, TX

The Michael & Susan Dell Foundation funds education, health, jobs and livelihoods, and family economic stability, with its deepest U.S. focus in Texas and additional work across the U.S. and internationally. In 2024 it awarded 835 grants totaling about $164.6 million; grants ranged from $75 to $50 million, with a median of $19,324. It accepts unsolicited requests through its online application process.

American Heart Association Inc

Dallas, TX

The American Heart Association funds basic, clinical, behavioral, translational and population research on cardiovascular, cerebrovascular and brain health, along with research training and education programs. In 2025 it awarded 833 grants totaling about $198 million; amounts ranged from $5,000 to nearly $9.93 million, with a median of $20,000. Research awards are for eligible U.S.-based nonprofit institutions, and the profile describes a formal proposal process but does not state whether unsolicited requests are accepted.