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PPMI Biofluid Biomarkers Program RFA Grant

The Michael J Fox Foundation for Parkinson's Research

Funding Amount

Up to US $750,000

Deadline

Rolling / Open

Grant Type

Foundation

Overview

The PPMI Biofluid Biomarkers Program RFA invites collaborators to enhance Parkinson's disease (PD) research through validated biomarker assays. Projects should focus on identifying alpha-synuclein pathology, understanding PD initiation and progression biologically, characterizing known dementia biomarkers, and correlating clinical progression. Funding of up to $750,000 is available, reflecting the scope of work proposed. This initiative aims to improve the biological understanding of PD and related disorders.

This Parkinson’s Progression Markers Initiative (PPMI) program seeks to identify collaborators who have analytically validated biomarker assays to deploy in existing PPMI biosamples to enhance the biological definition of Parkinson’s disease (PD) and related disorders, both before and after symptom onset.
Projects must address the following strategic goals:

  • Identify biomarkers of alpha-synuclein pathology beyond the alpha-synuclein seed amplification assay.
  • Understand biologic endotypes of initiation/progression of PD using targeted/unbiased omics.
  • Comprehensively characterize known biomarkers of dementia, neurodegeneration and copathology.
  • Advance characterization across the progression of PD to predict and correlate with progression on motor, cognitive and other clinical domains.
  • Funding

Up to $750,000. Requested support should be commensurate with work proposed.

What The Michael J Fox Foundation for Parkinson's Research actually gave

Source: IRS Form 990, 2025

Grants in 2025
149
Total given
$201.5M
Median grant
$426K
Range
$5,850–$16.65M
  • By dollars: California 27%, Massachusetts 17%, Pennsylvania 9%. Top recipient cities: New York, NY; Cambridge, MA; San Francisco, CA.
  • 0% of grants with a stated purpose were for general or operating support.
  • 32% of recipients were new grantees, not repeat recipients.

Example grants

  • Indiana University · Bloomington, IN

    Parkinson's research

    $16.65M

  • Greenphire · King of Prussia, PA

    Parkinson's research

    $12.71M

  • SB Technology Inc · Palo Alto, CA

    Parkinson's research

    $12.09M

  • Parkinson's Foundation · New York, NY

    Parkinson's research

    $7.6M

  • Casma Therapeutics · Cambridge, MA

    Parkinson's research

    $6.72M

IRS Form 990, 2025. Amounts as reported by the funder. Full 990 history →

Focus Areas & Funding Uses

Fields of Work

  • Science research

Categories

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