PPMI Biofluid Biomarkers Program RFA Grant
Funding Amount
Up to US $750,000
Deadline
Rolling / Open
Grant Type
Foundation
Overview
The PPMI Biofluid Biomarkers Program RFA invites collaborators to enhance Parkinson's disease (PD) research through validated biomarker assays. Projects should focus on identifying alpha-synuclein pathology, understanding PD initiation and progression biologically, characterizing known dementia biomarkers, and correlating clinical progression. Funding of up to $750,000 is available, reflecting the scope of work proposed. This initiative aims to improve the biological understanding of PD and related disorders.
This Parkinson’s Progression Markers Initiative (PPMI) program seeks to identify collaborators who have analytically validated biomarker assays to deploy in existing PPMI biosamples to enhance the biological definition of Parkinson’s disease (PD) and related disorders, both before and after symptom onset.
Projects must address the following strategic goals:
- Identify biomarkers of alpha-synuclein pathology beyond the alpha-synuclein seed amplification assay.
- Understand biologic endotypes of initiation/progression of PD using targeted/unbiased omics.
- Comprehensively characterize known biomarkers of dementia, neurodegeneration and copathology.
- Advance characterization across the progression of PD to predict and correlate with progression on motor, cognitive and other clinical domains.
- Funding
Up to $750,000. Requested support should be commensurate with work proposed.
What The Michael J Fox Foundation for Parkinson's Research actually gave
Source: IRS Form 990, 2025
- Grants in 2025
- 149
- Total given
- $201.5M
- Median grant
- $426K
- Range
- $5,850–$16.65M
- By dollars: California 27%, Massachusetts 17%, Pennsylvania 9%. Top recipient cities: New York, NY; Cambridge, MA; San Francisco, CA.
- 0% of grants with a stated purpose were for general or operating support.
- 32% of recipients were new grantees, not repeat recipients.
Example grants
Indiana University · Bloomington, IN
Parkinson's research
$16.65M
Greenphire · King of Prussia, PA
Parkinson's research
$12.71M
SB Technology Inc · Palo Alto, CA
Parkinson's research
$12.09M
Parkinson's Foundation · New York, NY
Parkinson's research
$7.6M
Casma Therapeutics · Cambridge, MA
Parkinson's research
$6.72M
Focus Areas & Funding Uses
Fields of Work
- Science research
Categories
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