NIH Collaborative International Research Project (Parent PF5 Clinical Trial Optional)

Q: How much funding does NIH Collaborative International Research Project (Parent PF5 Clinical Trial Optional) provide?

Funding amounts vary. Check the grant details for specifics.

National Institutes of Health

Federal Grants for Science Research Grants for Global Health

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Funding Amount

Varies

Deadline

May 7, 2029

1125 days left

Grant Type

federal

Overview

NIH Collaborative International Research Project (Parent PF5 Clinical Trial Optional)

The National Institutes of Health (NIH) seeks to advance its mission by maintaining strong, productive, and secure international research collaborations in support of the NIH mission. The NIH Collaborative International Research Project (Parent Announcement) supports international research collaborations. This opportunity specifically implements an award structure of prime domestic awards with independent foreign awards that are linked to the prime. This structure provides NIH with oversight capacity for international collaborations, and allows NIH to track international funding, as identified in NOT-OD-25-104. This funding opportunity is specifically designed for NIH to support funded international collaborations between a domestic prime organization and foreign organizations. This NOFO should not be used for foreign consultants, purchasing unique equipment or supplies from foreign vendors, foreign collaborations that do not involve NIH funding or any other foreign component that would not result in a foreign subaward. All collaborative international research project applications must include at least 1 international subproject. The proposed project must be related to the programmatic interests of one or more of the participating NIH Institutes, Centers and Offices (ICOs) based on their scientific missions. The application will be evaluated as a whole, and the international subproject(s) will be evaluated on whether the project presents special opportunities for furthering research programs through the use of unusual talent, resources, populations, or environmental conditions in other countries that are not readily available in the United States or that augment existing United States resources, and whether the proposed project has specific relevance to the mission and objectives of the ICO and has the potential for significantly advancing the health sciences in the United States.

Details

Agency: National Institutes of Health
Department: Department of Health and Human Services
Opportunity #: PA-26-002
Instrument: grant

Eligibility

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility. Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organization) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.One or more International Project is required.This funding opportunity is specifically designed to support funded international collaborations between a domestic prime organization and foreign organizations. This NOFO should not be used for projects in which the only international elements are foreign consultants, purchasing unique equipment or supplies from foreign vendors, foreign collaborations that do not involve NIH funding or any other foreign component that would not result in a foreign subaward.

Eligibility

Eligible Applicant Types

special_district_governmentsindependent_school_districtsother_native_american_tribal_organizationssmall_businessescounty_governmentsfederally_recognized_native_american_tribal_governmentsstate_governmentsnonprofits_non_higher_education_without_501c3public_and_indian_housing_authoritiesprivate_institutions_of_higher_educationcity_or_township_governmentsnonprofits_non_higher_education_with_501c3for_profit_organizations_other_than_small_businessesotherpublic_and_state_institutions_of_higher_education

How to Apply

PA-26-002-Full-Announcement.html

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<title>PA-26-002: NIH Collaborative International Research Project (Parent PF5 Clinical Trial Optional)</title>

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<div id="page-title" class="heading1" tabindex="0">Department of Health and Human Services</div>

<div>

<div data-element-id="269884" data-element-has-label="false" data-element-required="false" data-element-has-value="true" data-section-code="OI" data-element-type="TEXT">
<a id='_bookmark269884' tabindex='-1' aria-hidden='true'></a><a name="_Part 1. Overview Information"></a><h1>Part 1. Overview Information</h1>
</div>

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<div class="col-md-4 datalabel" tabindex="0" data-element-id="269885" data-element-required="true" data-element-has-value="true" data-section-code="OI" data-element-type="TEXT">
<a id='_bookmark269885' tabindex='-1' aria-hidden='true'></a>Participating Organization(s)
</div>
<div class=" col-md-8 datacolumn">
<p>National Institutes of Health (<a href="http://www.nih.gov">NIH</a>)</p>
</div>
</div>

<div class="row" data-index="4">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="269887" data-element-required="true" data-element-has-value="true" data-section-code="OI" data-element-type="LINKED_ELEMENT">
<a id='_bookmark269887' tabindex='-1' aria-hidden='true'></a>Components of Participating Organizations
</div>
<div class=" col-md-8 datacolumn">
<p>Office of The Director, National Institutes of Health (<a href="https://www.nih.gov/institutes-nih/nih-office-director" target="_blank" rel="noreferrer">OD</a>)
<p>National Eye Institute (<a href="https://www.nei.nih.gov/" target="_blank" rel="noreferrer">NEI</a>)
</p>
<p>National Heart, Lung, and Blood Institute (<a href="https://www.nhlbi.nih.gov/" target="_blank" rel="noreferrer">NHLBI</a>)
</p>
<p>National Human Genome Research Institute (<a href="https://www.genome.gov/" target="_blank" rel="noreferrer">NHGRI</a>)
</p>
<p>National Institute on
Aging (<a href="https://www.nia.nih.gov/" target="_blank" rel="noreferrer">NIA</a>)
</p>
<p>National Institute on Alcohol Abuse and Alcoholism (<a href="https://www.niaaa.nih.gov/" target="_blank" rel="noreferrer">NIAAA</a>)
</p>
<p>National Institute of Allergy and Infectious Diseases (<a href="https://www.niaid.nih.gov/" target="_blank" rel="noreferrer">NIAID</a>)
</p>
<p>National Institute of Arthritis and Musculoskeletal and Skin Diseases (<a href="https://www.niams.nih.gov/" target="_blank" rel="noreferrer">NIAMS</a>)
</p>
<p>National Institute of Biomedical Imaging and Bioengineering (<a href="https://www.nibib.nih.gov/" target="_blank" rel="noreferrer">NIBIB</a>)
</p>
<p>Eunice Kennedy Shriver National Institute of Child Health and Human Development (<a href="https://www.nichd.nih.gov/" target="_blank" rel="noreferrer">NICHD</a>)
</p>
<p>National Institute on Deafness and Other Communication Disorders (<a href="https://www.nidcd.nih.gov/" target="_blank" rel="noreferrer">NIDCD</a>)
</p>
<p>National Institute of Dental and Craniofacial Research (<a href="https://www.nidcr.nih.gov/" target="_blank" rel="noreferrer">NIDCR</a>)
</p>
<p>National Institute of Diabetes and Digestive and Kidney Diseases (<a href="https://www.niddk.nih.gov/" target="_blank" rel="noreferrer">NIDDK</a>)
</p>
<p>National Institute on Drug Abuse (<a href="https://www.drugabuse.gov/" target="_blank" rel="noreferrer">NIDA</a>)
</p>
<p>National Institute of Environmental Health Sciences (<a href="https://www.niehs.nih.gov/" target="_blank" rel="noreferrer">NIEHS</a>)
</p>
<p>National Institute of General Medical Sciences (<a href="https://www.nigms.nih.gov/" target="_blank" rel="noreferrer">NIGMS</a>)
</p>
<p>National Institute of Mental Health (<a href="https://www.nimh.nih.gov/index.shtml" target="_blank" rel="noreferrer">NIMH</a>)
</p>
<p>National Institute of Neurological Disorders and
Stroke (<a href="https://www.ninds.nih.gov/" target="_blank" rel="noreferrer">NINDS</a>)
</p>
<p>National Institute of Nursing Research (<a href="https://www.ninr.nih.gov/" target="_blank" rel="noreferrer">NINR</a>)
</p>
<p>National Institute on Minority Health and Health Disparities (<a href="https://www.nimhd.nih.gov/" target="_blank" rel="noreferrer">NIMHD</a>)
</p>
<p>National Library of Medicine (<a href="https://www.nlm.nih.gov/" target="_blank" rel="noreferrer">NLM</a>)
</p>
<p>National Center for Complementary and Integrative Health (<a href="https://nccih.nih.gov/" target="_blank" rel="noreferrer">NCCIH</a>)
</p>
<p>National Center for Advancing Translational Sciences (<a href="https://ncats.nih.gov/" target="_blank" rel="noreferrer">NCATS</a>)
</p>
<p>Division of Program Coordination, Planning and Strategic Initiatives, Office of Research Infrastructure Programs (<a href="https://orip.nih.gov/" target="_blank" rel="noreferrer">ORIP</a>)
</p>
<p>Office of Strategic Coordination (<a href="https://commonfund.nih.gov/" target="_blank" rel="noreferrer">Common Fund</a>)
</p>
<p>National Cancer Institute (<a href="https://www.cancer.gov/" target="_blank" rel="noreferrer">NCI</a>)
</p>

<p>All applications to this funding opportunity announcement should fall within the mission of the Institutes/Centers. The following NIH Offices may co-fund applications assigned to those Institutes/Centers.
</p>
<p>Office of Research on Women's Health (<a href="https://orwh.od.nih.gov/" target="_blank" rel="noreferrer">ORWH</a>)
</p>
<p>INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (<a href="https://www.nih.gov/include-project" target="_blank" rel="noreferrer">INCLUDE Project</a>)
</p>
<p>Office of Data Science Strategy (<a href="https://datascience.nih.gov/about/odss" target="_blank" rel="noreferrer">ODSS</a>)
</p>
</div>
</div>

<div class="row" data-index="6">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="269889" data-element-required="true" data-element-has-value="true" data-section-code="OI" data-element-type="LINKED_ELEMENT">
<a id='_bookmark269889' tabindex='-1' aria-hidden='true'></a>Funding Opportunity Title
</div>
<div class=" col-md-8 datacolumn">
<span class="title">NIH Collaborative International Research Project (Parent PF5 Clinical Trial Optional)</span>
</div>
</div>

<div class="row" data-index="7">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="269890" data-element-required="false" data-element-has-value="true" data-section-code="OI" data-element-type="TEXT">
<a id='_bookmark269890' tabindex='-1' aria-hidden='true'></a>Activity Code
</div>
<div class=" col-md-8 datacolumn">
<p><a href="https://grants.nih.gov/funding/activity-codes/PF5">PF5</a> Collaborative International Research Project</p>
</div>
</div>

<div class="row" data-index="8">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="269891" data-element-required="true" data-element-has-value="true" data-section-code="OI" data-element-type="LINKED_ELEMENT">
<a id='_bookmark269891' tabindex='-1' aria-hidden='true'></a>Announcement Type
</div>
<div class=" col-md-8 datacolumn">
New
</div>
</div>

<div class="row" data-index="9">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="269892" data-element-required="true" data-element-has-value="true" data-section-code="OI" data-element-type="TEXT">
<a id='_bookmark269892' tabindex='-1' aria-hidden='true'></a>Related Notices
</div>
<div class=" col-md-8 datacolumn">
<ul><li>Check for any recent <a href="https://grants.nih.gov/grants/guide/url_redirect.php?id=11163">Notices of NIH Policy Changes</a> that may impact application requirements.</li><li><strong>September 12, 2025</strong> - New Application Structure for NIH-Funded International Collaborations. See Notice <a href="https://grants.nih.gov/grants/guide/notice-files/NOT-OD-25-155.html">NOT-OD-25-155</a>.</li><li><strong>May 1, 2025 </strong>- Implementation of Updated NIH Policy on Foreign Subawards. See Notice <a href="https://grants.nih.gov/grants/guide/notice-files/NOT-OD-25-104.html">NOT-OD-25-104</a>.</li></ul>
</div>
</div>

<div class="row" data-index="10">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="269893" data-element-required="true" data-element-has-value="true" data-section-code="OI" data-element-type="LINKED_ELEMENT">
<a id='_bookmark269893' tabindex='-1' aria-hidden='true'></a>Funding Opportunity Number (FON)
</div>
<div class=" col-md-8 datacolumn">
<span class="noticenum">PA-26-002</span>
</div>
</div>

<div class="row" data-index="11">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="269894" data-element-required="true" data-element-has-value="true" data-section-code="OI" data-element-type="LINKED_ELEMENT">
<a id='_bookmark269894' tabindex='-1' aria-hidden='true'></a>Companion Notice of Funding Opportunity
</div>
<div class=" col-md-8 datacolumn">
None
</div>
</div>

<div class="row" data-index="12">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="269895" data-element-required="true" data-element-has-value="true" data-section-code="OI" data-element-type="TEXT">
<a id='_bookmark269895' tabindex='-1' aria-hidden='true'></a>Number of Applications
</div>
<div class=" col-md-8 datacolumn">
<p>See <a href="#_3._Additional_Information">Section III. 3. Additional Information on Eligibility</a>.</p>
</div>
</div>

<div class="row" data-index="13">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="269896" data-element-required="true" data-element-has-value="true" data-section-code="OI" data-element-type="LINKED_ELEMENT">
<a id='_bookmark269896' tabindex='-1' aria-hidden='true'></a>Assistance Listing Number(s)
</div>
<div class=" col-md-8 datacolumn">
93.310, 93.286, 93.361, 93.172, 93.866, 93.394, 93.350, 93.395, 93.396, 93.397, 93.393, 93.398, 93.399, 93.867, 93.233, 93.837, 93.838, 93.865, 93.839, 93.840, 93.279, 93.121, 93.879, 93.313, 93.173, 93.372, 93.213, 93.242, 93.847, 93.113, 93.846, 93.351, 93.859, 93.307, 93.273, 93.855, 93.853
</div>
</div>

<div class="row" data-index="14">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="269897" data-element-required="true" data-element-has-value="true" data-section-code="OI" data-element-type="TEXT">
<a id='_bookmark269897' tabindex='-1' aria-hidden='true'></a>Notice of Funding Opportunity Purpose
</div>
<div class=" col-md-8 datacolumn">
<p>The National Institutes of Health (NIH) seeks to advance its mission by maintaining strong, productive, and secure international research collaborations in support of the NIH mission. The NIH Collaborative International Research Project (Parent Announcement) supports international research collaborations. This opportunity specifically implements an award structure of prime domestic awards with independent foreign awards that are linked to the prime. This structure provides NIH with oversight capacity for international collaborations, and allows NIH to track international funding, as identified in <a href="https://grants.nih.gov/grants/guide/notice-files/NOT-OD-25-104.html">NOT-OD-25-104</a>. This funding opportunity is specifically designed for NIH to support funded international collaborations between a domestic prime organization and foreign organizations. This NOFO should not be used for foreign consultants, purchasing unique equipment or supplies from foreign vendors, foreign collaborations that do not involve NIH funding, or any other foreign component that would not result in a foreign subaward.</p><p>All collaborative international research project applications must include at least 1 international subproject. The proposed project must be related to the programmatic interests of one or more of the participating NIH Institutes, Centers and Offices (ICOs) based on their scientific missions. The application will be evaluated as a whole, and the international subproject(s) will be evaluated on whether the project presents special opportunities for furthering research programs through the use of unusual talent, resources, populations, or environmental conditions in other countries that are not readily available in the United States or that augment existing United States resources, and whether the proposed project has specific relevance to the mission and objectives of the ICO and has the potential for significantly advancing the health sciences in the United States. </p>
</div>
</div>

<div class="row" data-index="16">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="269899" data-element-required="true" data-element-has-value="true" data-section-code="OI" data-element-type="TEXT">
<a id='_bookmark269899' tabindex='-1' aria-hidden='true'></a>Funding Opportunity Goal(s)
</div>
<div class=" col-md-8 datacolumn">
<p>NIHs mission is to seek fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance health, lengthen life, and reduce illness and disability.</p><p>The goals are:</p><ul><li>to foster fundamental creative discoveries, innovative research strategies, and their applications as a basis for ultimately protecting and improving health;</li><li>to develop, maintain, and renew scientific human and physical resources that will ensure the Nation's capability to prevent disease;</li><li>to expand the knowledge base in medical and associated sciences in order to enhance the Nation's economic well-being and ensure a continued high return on the public investment in research; and</li><li>to exemplify and promote the highest level of scientific integrity, public accountability, and social responsibility in the conduct of science.</li></ul><p>In realizing these goals, the NIH provides leadership and direction to programs designed to improve the health of the Nation by conducting and supporting research:</p><ul><li>in the causes, diagnosis, prevention, and cure of human diseases;</li><li>in the processes of human growth and development;</li><li>in the biological effects of environmental contaminants;</li><li>in the understanding of mental, addictive and physical disorders; and</li><li>in directing programs for the collection, dissemination, and exchange of information in medicine and health, including the development and support of medical libraries and the training of medical librarians and other health information specialists.</li></ul><p>See the <a href="https://www.nih.gov/about-nih/mission-goals">NIH Mission Statement</a> and the <a href="https://www.nih.gov/about-nih/nih-director/statements/advancing-nihs-mission-through-unified-strategy">NIH Directors Statement of Priorities</a>, entitled Advancing NIHs Mission Through a Unified Strategy. </p>
</div>
</div>

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<a id='_bookmark269900' tabindex='-1' aria-hidden='true'></a><a name="_Key Dates"></a><h2>Key Dates</h2>
</div>

<div class="row" data-index="18">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="269901" data-element-required="true" data-element-has-value="true" data-section-code="KD" data-element-type="DATE">
<a id='_bookmark269901' tabindex='-1' aria-hidden='true'></a>Posted Date
</div>
<div class=" col-md-8 datacolumn">
January 20, 2026
</div>
</div>

<div class="row" data-index="19">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="269902" data-element-required="true" data-element-has-value="true" data-section-code="KD" data-element-type="LINKED_ELEMENT">
<a id='_bookmark269902' tabindex='-1' aria-hidden='true'></a>Open Date (Earliest Submission Date)
</div>
<div class=" col-md-8 datacolumn">
April 25, 2026
</div>
</div>

<div data-element-id="269903" data-element-has-label="false" data-element-required="true" data-element-has-value="true" data-section-code="KD" data-element-type="LINKED_ELEMENT">
<a id='_bookmark269903' tabindex='-1' aria-hidden='true'></a>
The following table includes NIH <a href="https://grants.nih.gov/grants/how-to-apply-application-guide/due-dates-and-submission-policies/due-dates.htm" target="_blank" rel="noreferrer">standard due dates</a> marked with an asterisk.
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<tr>
<th scope="col" colspan="3" style="border:2px solid #bcbcbc;" class="text-center">Application Due Dates</th>
<th scope="col" colspan="3" style="border:2px solid #bcbcbc;" class="text-center">Review and Award Cycles</th>
</tr>
<tr>
<th scope="col" style="width:16.66%;border-left:2px solid #bcbcbc;" class="text-center">New</th>
<th scope="col" style="width:16.66%" class="text-center">Renewal / Resubmission / Revision (as allowed)</th>
<th scope="col" style="width:16.66%;border-right:2px solid #bcbcbc;" class="text-center">AIDS - New/Renewal/Resubmission/Revision, as allowed</th>
<th scope="col" style="width:16.66%" class="text-center">Scientific Merit Review</th>
<th scope="col" style="width:16.66%" class="text-center">Advisory Council Review</th>
<th scope="col" style="width:16.66%;border-right:2px solid #bcbcbc;" class="text-center">Earliest Start Date</th>
</tr>
</thead>
<tbody>
<tr>
<td>
May 25, 2026 *
</td>
<td>
May 25, 2026 *
</td>
<td>
September 07, 2026 *
</td>
<td>November 2026</td>
<td> January 2027

</td>
<td>April 2027</td>
</tr>
<tr>
<td>
September 25, 2026 *
</td>
<td>
September 25, 2026 *
</td>
<td>
January 07, 2027 *
</td>
<td>March 2027</td>
<td> May 2027

</td>
<td>July 2027</td>
</tr>
<tr>
<td>
January 25, 2027 *
</td>
<td>
January 25, 2027 *
</td>
<td>
May 07, 2027 *
</td>
<td>July 2027</td>
<td> October 2027

</td>
<td>December 2027</td>
</tr>
<tr>
<td>
May 25, 2027 *
</td>
<td>
May 25, 2027 *
</td>
<td>
September 07, 2027 *
</td>
<td>November 2027</td>
<td> January 2028

</td>
<td>April 2028</td>
</tr>
<tr>
<td>
September 25, 2027 *
</td>
<td>
September 25, 2027 *
</td>
<td>
January 07, 2028 *
</td>
<td>March 2028</td>
<td> May 2028

</td>
<td>July 2028</td>
</tr>
<tr>
<td>
January 25, 2028 *
</td>
<td>
January 25, 2028 *
</td>
<td>
May 07, 2028 *
</td>
<td>July 2028</td>
<td> October 2028

</td>
<td>December 2028</td>
</tr>
<tr>
<td>
May 25, 2028 *
</td>
<td>
May 25, 2028 *
</td>
<td>
September 07, 2028 *
</td>
<td>November 2028</td>
<td> January 2029

</td>
<td>April 2029</td>
</tr>
<tr>
<td>
September 25, 2028 *
</td>
<td>
September 25, 2028 *
</td>
<td>
January 07, 2029 *
</td>
<td>March 2029</td>
<td> May 2029

</td>
<td>July 2029</td>
</tr>
<tr>
<td>
January 25, 2029 *
</td>
<td>
January 25, 2029 *
</td>
<td>
May 07, 2029 *
</td>
<td>July 2029</td>
<td> October 2029

</td>
<td>December 2029</td>
</tr>
</tbody>
</table>
</div>

<div data-element-id="269905" data-element-has-label="false" data-element-required="true" data-element-has-value="true" data-section-code="KD" data-element-type="TEXT">
<a id='_bookmark269905' tabindex='-1' aria-hidden='true'></a><p>All applications are due by 5:00 PM local time of applicant organization. </p>

<p>Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.</p>
</div>

<div class="row" data-index="28">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="269911" data-element-required="true" data-element-has-value="true" data-section-code="KD" data-element-type="LINKED_ELEMENT">
<a id='_bookmark269911' tabindex='-1' aria-hidden='true'></a>Expiration Date
</div>
<div class=" col-md-8 datacolumn">
May 08, 2029
</div>
</div>

<div class="row" data-index="29">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="269912" data-element-required="true" data-element-has-value="true" data-section-code="KD" data-element-type="TEXT">
<a id='_bookmark269912' tabindex='-1' aria-hidden='true'></a>Due Dates for E.O. 12372
</div>
<div class=" col-md-8 datacolumn">
<p>Not Applicable</p>
</div>
</div>

<div class="heading4" tabindex="0" data-element-id="269913" data-element-required="true" data-element-has-value="true" data-section-code="KD" data-element-type="TEXT">
<a id='_bookmark269913' tabindex='-1' aria-hidden='true'></a>Required Application Instructions
</div>

<div data-element-id="269913" data-element-has-label="true" data-element-required="true" data-element-has-value="true" data-section-code="KD" data-element-type="TEXT">
<p>It is critical that applicants follow the Multi-Project (M) Instructions in the <a href="https://grants.nih.gov/grants/guide/url_redirect.htm?id=82400">How to Apply - Application Guide</a>, except where instructed to do otherwise (in this NOFO or in a Notice from the <a href="http://grants.nih.gov/grants/guide/url_redirect.htm?id=11164">NIH Guide for Grants and Contracts</a>). Conformance to all requirements (both in the <a href="https://grants.nih.gov/grants/guide/url_redirect.htm?id=82400">How to Apply - Application Guide</a> and the NOFO) is required and strictly enforced. Applicants must read and follow all application instructions in the <a href="https://grants.nih.gov/grants/guide/url_redirect.htm?id=82400">How to Apply - Application Guide</a> as well as any program-specific instructions noted in Section IV. When the program-specific instructions deviate from those in the <a href="https://grants.nih.gov/grants/guide/url_redirect.htm?id=82400">How to Apply - Application Guide</a>, follow the program-specific instructions. <b>Applications that do not comply with these instructions may be delayed or not accepted for review.</b></p>
</div>

<div data-element-id="269914" data-element-has-label="false" data-element-required="true" data-element-has-value="true" data-section-code="KD" data-element-type="TEXT">
<a id='_bookmark269914' tabindex='-1' aria-hidden='true'></a><p style="margin-left:0in;">There are several options available to submit your application through Grants.gov to NIH and Department of Health and Human Services partners. You <strong>must</strong> use one of these submission options to access the application forms for this opportunity.</p><ol><li>Use the <a href="https://public.era.nih.gov/assist/landing.era?tabId=0819b5fc-46b7-4f02-b6b7-127e5a4e19fa">NIH ASSIST system</a> to prepare, submit and track your application online.</li><li>Use an institutional system-to-system (S2S) solution to prepare and submit your application to Grants.gov and <a href="https://public.era.nih.gov/commons/">eRA Commons</a> to track your application. Check with your institutional officials regarding availability.</li></ol>
</div>

<div id="tocDiv">
<div class="heading1" tabindex="0">Table of Contents</div>
<div class="toc-link"><a href="#_Part1.OverviewInformation">Part 1. Overview Information</a></div><div class="toc-link P_SingleIndent"><a href="#_KeyDates">Key Dates</a></div><div class="toc-link"><a href="#_Part2.FullTextofAnnouncement">Part 2. Full Text of Announcement</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionI.NoticeofFundingOpportunityDescription">Section I. Notice of Funding Opportunity Description</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionII.AwardInformation">Section II. Award Information</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionIII.EligibilityInformation">Section III. Eligibility Information</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionIV.ApplicationandSubmissionInformation">Section IV. Application and Submission Information</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionV.ApplicationReviewInformation">Section V. Application Review Information</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionVI.AwardAdministrationInformation">Section VI. Award Administration Information</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionVII.AgencyContacts">Section VII. Agency Contacts</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionVIII.OtherInformation">Section VIII. Other Information</a></div>
</div><br/>

<div data-element-id="269916" data-element-has-label="false" data-element-required="true" data-element-has-value="true" data-section-code="FOD" data-element-type="TEXT">
<a id='_bookmark269916' tabindex='-1' aria-hidden='true'></a><a name="_Part 2. Full Text of Announcement"></a><h1>Part 2. Full Text of Announcement</h1>
</div>

<div data-element-id="269917" data-element-has-label="false" data-element-required="true" data-element-has-value="true" data-section-code="FOD" data-element-type="TEXT">
<a id='_bookmark269917' tabindex='-1' aria-hidden='true'></a><a name="_Section I. Notice of Funding Opportunity Description"></a><h2>Section I. Notice of Funding Opportunity Description</h2>
</div>

<div data-element-id="269918" data-element-has-label="false" data-element-required="true" data-element-has-value="true" data-section-code="FOD" data-element-type="TEXT">
<a id='_bookmark269918' tabindex='-1' aria-hidden='true'></a><p>The National Institutes of Health (NIH) seeks to advance its mission by maintaining strong, productive, and secure international research collaborations in support of the NIH mission. The NIH Collaborative International Research Project (PF5) is specifically designed to support funded international collaborations between a domestic (U.S.-based) prime organization and foreign organizations. As described in <a href="https://grants.nih.gov/grants/guide/notice-files/NOT-OD-25-104.html">NOT-OD-25-104</a>, this funding opportunity is structured to support collaborative projects such as those that had previously been awarded as domestic awards with one or more consortia/subawards to foreign organizations.</p><p>Each PF5 application should support research project(s) in a scientific area that represents the investigators' specific interests and competencies and that fall within the mission of participating NIH ICOs.</p><p>As further described in <a href="#_Section_IV._Application_1">Section IV. Application and Submission Information</a>, each PF5 application must include at a minimum the following components: Overall, Research Project, and International Project.</p><p>The Overall component should provide a broad overview of the proposed PF5 including the goals of the program, why an international collaboration is critical for addressing these goals, and how the project will be coordinated across international sites.</p><p>The Research Project component(s), led by the domestic applicant organization, should provide sufficient details of the significance, innovation, and approach of the project to allow an assessment of the scientific and technical merit.</p><p>The International Project component(s) should describe the scope of work, unique attributes, and contributions of the foreign organization(s). It is expected that the scope of the International Project supports the aims identified in the Overall and Research Project components. Should the PF5 project be selected for funding consideration, the International Project(s) will be disaggregated from the PF5 and assigned their own grant number (i.e., RF2 Linked International Research Project); therefore, it is critical that each International Project has a clearly described scope of work and demonstrated ability to manage the administrative aspects of an award. See <a href="#_2._Review_and">Section V.2. Review and Selection Process</a> for more information on the disaggregation process. </p><p>In addition to the required components described above, the PF5 applicant has the option of including Core(s) and/or Institutional Career Development and Training components. These optional components are intended for international collaborations that will pursue complex activities such as NIH program projects (e.g., P01s), centers (e.g., P50), and institutional training programs (e.g., K12). Before utilizing these more complex structures, applicants are strongly encouraged to discuss their plans with their intended IC Program Officers. </p><p>New applications must not include elements of resubmission or renewal including but not limited to progress reports or mention of a prior application or award history of the project.</p><p>This funding opportunity is specifically designed to support funded international collaborations between a domestic prime organization and foreign organizations. This NOFO should not be used for foreign consultants, purchasing unique equipment or supplies from foreign vendors, foreign collaborations that do not involve NIH funding, or any other foreign component that would not result in a foreign subaward. </p>
</div>

<div data-element-id="269920" data-element-has-label="false" data-element-required="false" data-element-has-value="true" data-section-code="FOD" data-element-type="TEXT">
<a id='_bookmark269920' tabindex='-1' aria-hidden='true'></a><p>Investigators proposing NIH-defined clinical trials may refer to the <a href="https://researchmethodsresources.nih.gov/">Research Methods Resources</a> website for information about developing statistical methods and study designs.</p>
</div>

<div data-element-id="269921" data-element-has-label="false" data-element-required="true" data-element-has-value="true" data-section-code="FOD" data-element-type="TEXT">
<a id='_bookmark269921' tabindex='-1' aria-hidden='true'></a><p>See <a href="#">Section VIII. Other Information</a> for award authorities and regulations.</p>
</div>

<div data-element-id="269922" data-element-has-label="false" data-element-required="true" data-element-has-value="true" data-section-code="AI" data-element-type="TEXT">
<a id='_bookmark269922' tabindex='-1' aria-hidden='true'></a><a name="_Section II. Award Information"></a><h2>Section II. Award Information</h2>
</div>

<div class="row" data-index="40">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="269923" data-element-required="true" data-element-has-value="true" data-section-code="AI" data-element-type="TEXT">
<a id='_bookmark269923' tabindex='-1' aria-hidden='true'></a>Funding Instrument
</div>
<div class=" col-md-8 datacolumn">
<p>Grant: A financial assistance mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity.</p>
</div>
</div>

<div class="row" data-index="41">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="269924" data-element-required="true" data-element-has-value="true" data-section-code="AI" data-element-type="LINKED_ELEMENT">
<a id='_bookmark269924' tabindex='-1' aria-hidden='true'></a> Application Types Allowed
</div>
<div class=" col-md-8 datacolumn">
New
<br>
Renewal
<br>
Resubmission
<br>
Revision
<br>
</div>
</div>

<div class="row" data-index="42">
<div class="col-md-push-4 col-md-8 datacolumn">
<a id='_bookmark269925' tabindex='-1' aria-hidden='true'></a><p>Renewal and Revisions applications are only allowed for PF5 awards.</p><p>Resubmission applications are only allowed for PF5 applications. </p>
</div>
</div>

<div class="row" data-index="43">
<div class="col-md-push-4 col-md-8 datacolumn">
<a id='_bookmark269926' tabindex='-1' aria-hidden='true'></a><p>The <a href="http://grants.nih.gov/grants/guide/url_redirect.htm?id=11116"><font color="#0000ff">OER Glossary</font></a> and the <a href="https://grants.nih.gov/grants/guide/url_redirect.htm?id=82400">How to Apply - Application Guide</a> provides details on these application types. Only those application types listed here are allowed for this NOFO.</p>
</div>
</div>

<div class="row" data-index="44">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="269927" data-element-required="false" data-element-has-value="true" data-section-code="AI" data-element-type="TEXT">
<a id='_bookmark269927' tabindex='-1' aria-hidden='true'></a>Clinical Trial?
</div>
<div class=" col-md-8 datacolumn">
<p>Optional: Accepting applications that either propose or do not propose clinical trial(s).</p>
</div>
</div>

<div class="row" data-index="45">
<div class="col-md-push-4 col-md-8 datacolumn">
<a id='_bookmark269928' tabindex='-1' aria-hidden='true'></a><a href="https://grants.nih.gov/grants/guide/url_redirect.htm?id=82370">Need help determining whether you are doing a clinical trial?</a>
</div>
</div>

<div class="row" data-index="46">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="269929" data-element-required="true" data-element-has-value="true" data-section-code="AI" data-element-type="TEXT">
<a id='_bookmark269929' tabindex='-1' aria-hidden='true'></a>Funds Available and Anticipated Number of Awards
</div>
<div class=" col-md-8 datacolumn">
<p>The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.</p>
</div>
</div>

<div class="row" data-index="47">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="269930" data-element-required="true" data-element-has-value="true" data-section-code="AI" data-element-type="TEXT">
<a id='_bookmark269930' tabindex='-1' aria-hidden='true'></a>Award Budget
</div>
<div class=" col-md-8 datacolumn">
Application budgets are not limited but need to reflect the actual needs of the proposed project.
</div>
</div>

<div class="row" data-index="48">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="269931" data-element-required="true" data-element-has-value="true" data-section-code="AI" data-element-type="TEXT">
<a id='_bookmark269931' tabindex='-1' aria-hidden='true'></a>Award Project Period
</div>
<div class=" col-md-8 datacolumn">
<p>The scope of the proposed project should determine the project period. Generally, the maximum project period is 5 years for non-clinical trial(s) and up to 7 years for clinical trial(s). </p>
</div>
</div>

<div data-element-id="269932" data-element-has-label="false" data-element-required="true" data-element-has-value="true" data-section-code="AI" data-element-type="TEXT">
<a id='_bookmark269932' tabindex='-1' aria-hidden='true'></a><p>NIH grants policies as described in the <a href="http://grants.nih.gov/grants/guide/url_redirect.htm?id=11120">NIH Grants Policy Statement</a> will apply to the applications submitted and awards made from this NOFO.</p>
</div>

<div data-element-id="269933" data-element-has-label="false" data-element-required="true" data-element-has-value="true" data-section-code="EI" data-element-type="TEXT">
<a id='_bookmark269933' tabindex='-1' aria-hidden='true'></a><a name="_Section III. Eligibility Information"></a><h2>Section III. Eligibility Information</h2>
</div>

<div data-element-id="269934" data-element-has-label="false" data-element-required="true" data-element-has-value="true" data-section-code="EI" data-element-type="TEXT">
<a id='_bookmark269934' tabindex='-1' aria-hidden='true'></a><h4>1. Eligible Applicants</p>
</div>

<div class="heading4" tabindex="0" data-element-id="269935" data-element-required="true" data-element-has-value="true" data-section-code="EI" data-element-type="TEXT">
<a id='_bookmark269935' tabindex='-1' aria-hidden='true'></a>Eligible Organizations
</div>

<div data-element-id="269935" data-element-has-label="true" data-element-required="true" data-element-has-value="true" data-section-code="EI" data-element-type="TEXT">
<p>Higher Education Institutions - Includes all types</p><ul><li>Public/State Controlled Institutions of Higher Education</li><li>Private Institutions of Higher Education</li></ul><p>Nonprofits Other Than Institutions of Higher Education</p><ul><li>Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Higher Education)</li><li>Nonprofits without 501(c)(3) IRS Status (Other than Institutions of Higher Education)</li></ul><p>For-Profit Organizations</p><ul><li>Small Businesses</li><li>For-Profit Organizations (Other than Small Businesses)</li></ul><p>Local Governments</p><ul><li>State Governments</li><li>County Governments</li><li>City or Township Governments</li><li>Special District Governments</li><li>Indian/Native American Tribal Governments (Federally Recognized)</li><li>Indian/Native American Tribal Governments (Other than Federally Recognized)</li></ul>
</div>

<div data-element-id="269936" data-element-has-label="false" data-element-required="false" data-element-has-value="true" data-section-code="EI" data-element-type="TEXT">
<a id='_bookmark269936' tabindex='-1' aria-hidden='true'></a><p>Federal Governments</p>

<ul>
<li>Eligible Agencies of the Federal Government</li>
<li>U.S. Territory or Possession</li>
</ul>
</div>

<div data-element-id="269937" data-element-has-label="false" data-element-required="false" data-element-has-value="true" data-section-code="EI" data-element-type="TEXT">
<a id='_bookmark269937' tabindex='-1' aria-hidden='true'></a><p>Other</p>

<ul>
<li>Independent School Districts</li>
<li>Public Housing Authorities/Indian Housing Authorities</li>
<li>Native American Tribal Organizations (other than Federally recognized tribal governments)</li>
<li>Faith-based or Community-based Organizations</li>
<li>Regional Organizations</li>
</ul>
</div>

<div data-element-id="269939" data-element-has-label="false" data-element-required="true" data-element-has-value="true" data-section-code="EI" data-element-type="TEXT">
<a id='_bookmark269939' tabindex='-1' aria-hidden='true'></a><h4>Foreign Organizations/International Collaborations</h4>
</div>

<div data-element-id="269940" data-element-has-label="false" data-element-required="true" data-element-has-value="true" data-section-code="EI" data-element-type="RADIO_BUTTON">
<a id='_bookmark269940' tabindex='-1' aria-hidden='true'></a><p class="Normal">Non-domestic (non-U.S.) Entities (Foreign Organization) <strong>are not</strong> eligible to apply.</p>
</div>

<div data-element-id="269941" data-element-has-label="false" data-element-required="true" data-element-has-value="true" data-section-code="EI" data-element-type="RADIO_BUTTON">
<a id='_bookmark269941' tabindex='-1' aria-hidden='true'></a><p>Non-domestic (non-U.S.) components of U.S. Organizations <strong>are not</strong> eligible to apply.</p>
</div>

<div data-element-id="269942" data-element-has-label="false" data-element-required="true" data-element-has-value="true" data-section-code="EI" data-element-type="RADIO_BUTTON">
<a id='_bookmark269942' tabindex='-1' aria-hidden='true'></a><p class="Normal">Foreign components, as <a href="http://grants.nih.gov/grants/guide/url_redirect.htm?id=11118">defined in the NIH Grants Policy Statement</a>, <strong>are </strong>allowed. </p>
</div>

<div data-element-id="269943" data-element-has-label="false" data-element-required="true" data-element-has-value="true" data-section-code="EI" data-element-type="TEXT">
<a id='_bookmark269943' tabindex='-1' aria-hidden='true'></a><p>One or more International Project is required.</p><p>This funding opportunity is specifically designed to support funded international collaborations between a domestic prime organization and foreign organizations. This NOFO should not be used for projects in which the only international elements are foreign consultants, purchasing unique equipment or supplies from foreign vendors, foreign collaborations that do not involve NIH funding or any other foreign component that would not result in a foreign subaward.  </p>
</div>

<div class="heading4" tabindex="0" data-element-id="269945" data-element-required="true" data-element-has-value="true" data-section-code="EI" data-element-type="TEXT">
<a id='_bookmark269945' tabindex='-1' aria-hidden='true'></a>Required Registrations
</div>

<div data-element-id="269945" data-element-has-label="true" data-element-required="true" data-element-has-value="true" data-section-code="EI" data-element-type="TEXT">
<p><strong>Applicant organizations</strong></p><p>Applicant organizations must complete and maintain the following registrations as described in the <a href="https://grants.nih.gov/grants/guide/url_redirect.htm?id=82400">How to Apply- Application Guide</a> to be eligible to apply for or receive an award. All registrations must be completed prior to the application being submitted. Registration can take 6 weeks or more, so applicants should begin the registration process as soon as possible. Failure to complete registrations in advance of a due date is not a valid reason for a late submission, please reference <a href="http://grants.nih.gov/grants/guide/url_redirect.htm?id=82423">NIH Grants Policy Statement Section 2.3.9.2 Electronically Submitted Applications</a> for additional information.</p><ul><li><a href="https://grants.nih.gov/grants/guide/url_redirect.htm?id=82390">System for Award Management (SAM)</a> – Applicants must complete and maintain an active registration, <strong>which requires renewal at least annually</strong>. The renewal process may require as much time as the initial registration. SAM registration includes the assignment of a Commercial and Government Entity (CAGE) Code for domestic organizations which have not already been assigned a CAGE Code.<ul><li><a href="http://grants.nih.gov/grants/guide/url_redirect.htm?id=11176">NATO Commercial and Government Entity (NCAGE) Code</a> – Foreign organizations must obtain an NCAGE code (in lieu of a CAGE code) in order to register in SAM.</li><li>Unique Entity Identifier (UEI) - A UEI is issued as part of the SAM.gov registration process. The same UEI must be used for all registrations, as well as on the grant application.</li></ul></li><li><a href="https://era.nih.gov/">eRA Commons</a> - Once the unique organization identifier is established, organizations can register with eRA Commons in tandem with completing their Grants.gov registration; all registrations must be in place by time of submission. eRA Commons requires organizations to identify at least one Signing Official (SO) and at least one Program Director/Principal Investigator (PD/PI) account in order to submit an application.</li><li><a href="http://grants.nih.gov/grants/guide/url_redirect.htm?id=82300">Grants.gov</a> – Applicants must have an active SAM registration in order to complete the Grants.gov registration.</li></ul><p><strong>International Project Organizations</strong></p><p>Should the project be selected for funding, the International Project(s) will also be intended to fill the role as a recipient organization for the disaggregated award(s), and therefore must have all the necessary registrations completed, as listed above, at just-in-time. The foreign organization(s) are strongly encouraged to begin the registration process as soon as possible. Failure to complete registrations in a timely manner may delay funding if the project is selected for funding.</p><p><strong>Program Directors/Principal Investigators (PD(s)/

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Focus Areas & Funding Uses

Fields of Work

$2,000,000 - $5,000,000

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April 13, 2026

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NIH Collaborative International Research Project (Parent PF5 Clinical Trial Optional)

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NIH Collaborative International Research Project (Parent PF5 Clinical Trial Optional)

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Eligibility

Eligible Applicant Types

How to Apply

PA-26-002-Full-Announcement.html

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