National Centers for Cryo-electron Tomography (cryoET) (R24 -Clinical Trial Not Allowed)

Q: How much funding does National Centers for Cryo-electron Tomography (cryoET) (R24 -Clinical Trial Not Allowed) provide?

Funding amounts vary. Check the grant details for specifics.

Q: When is the deadline for National Centers for Cryo-electron Tomography (cryoET) (R24 -Clinical Trial Not Allowed)?

The deadline is January 26, 2027.

National Institutes of Health

Federal Grants for Science Research

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Funding Amount

Varies

Deadline

January 26, 2027

293 days left

Grant Type

federal

Overview

National Centers for Cryo-electron Tomography (cryoET) (R24 -Clinical Trial Not Allowed)

This Notice of Funding Opportunity (NOFO) is for support of National Centers for Cryoelectron Tomography (CryoET) to provide nationwide access to advanced cryoET instrumentation and technical support, and to assist investigators in acquiring the skills needed to perform cryoET studies.

Details

Agency: National Institutes of Health
Department: Department of Health and Human Services
Opportunity #: PAR-26-138
Instrument: grant

Eligibility

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/Foreign CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

Eligibility

Eligible Applicant Types

federally_recognized_native_american_tribal_governmentsother_native_american_tribal_organizationsnonprofits_non_higher_education_without_501c3for_profit_organizations_other_than_small_businessesnonprofits_non_higher_education_with_501c3public_and_state_institutions_of_higher_educationothercity_or_township_governmentsindependent_school_districtsprivate_institutions_of_higher_educationcounty_governmentspublic_and_indian_housing_authoritiessmall_businessesstate_governmentsspecial_district_governments

How to Apply

PAR-26-138-Full-Announcement.html

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<title>PAR-26-138: National Centers for Cryo-electron Tomography (cryoET) (R24 -Clinical Trial Not Allowed)</title>

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<div id="page-title" class="heading1" tabindex="0">Department of Health and Human Services</div>

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<a id='_bookmark261373' tabindex='-1' aria-hidden='true'></a><a name="_Part 1. Overview Information"></a><h1>Part 1. Overview Information</h1>
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<div class="col-md-4 datalabel" tabindex="0" data-element-id="261374" data-element-required="true" data-element-has-value="true" data-section-code="OI" data-element-type="TEXT">
<a id='_bookmark261374' tabindex='-1' aria-hidden='true'></a>Participating Organization(s)
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<p>National Institutes of Health (<a href="http://www.nih.gov">NIH</a>)</p>
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<a id='_bookmark261376' tabindex='-1' aria-hidden='true'></a>Components of Participating Organizations
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<p>National Institute of General Medical Sciences (<a href="https://www.nigms.nih.gov/" target="_blank" rel="noreferrer">NIGMS</a>)
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<div class="col-md-4 datalabel" tabindex="0" data-element-id="261378" data-element-required="true" data-element-has-value="true" data-section-code="OI" data-element-type="LINKED_ELEMENT">
<a id='_bookmark261378' tabindex='-1' aria-hidden='true'></a>Funding Opportunity Title
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<span class="title">National Centers for Cryo-electron Tomography (cryoET) (R24 -Clinical Trial Not Allowed)</span>
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<a id='_bookmark261379' tabindex='-1' aria-hidden='true'></a>Activity Code
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<p><a href="http://grants.nih.gov/grants/funding/ac_search_results.htm?text_curr=r24&Search.x=0&Search.y=0&Search_Type=Activity">R24</a> Resource-Related Research Projects</p>
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<a id='_bookmark261380' tabindex='-1' aria-hidden='true'></a>Announcement Type
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New
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<a id='_bookmark261381' tabindex='-1' aria-hidden='true'></a>Related Notices
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<ul><li>Check for any recent <a href="https://grants.nih.gov/grants/guide/url_redirect.php?id=11163">Notices of NIH Policy Changes</a> that may impact application requirements.</li></ul>
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<a id='_bookmark261382' tabindex='-1' aria-hidden='true'></a>Funding Opportunity Number (FON)
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<span class="noticenum">PAR-26-138</span>
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<a id='_bookmark261383' tabindex='-1' aria-hidden='true'></a>Companion Funding Opportunity
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None
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<a id='_bookmark261384' tabindex='-1' aria-hidden='true'></a>Number of Applications
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<p>See Part 2, Section III. 3. Additional Information on Eligibility.</p>
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<a id='_bookmark261385' tabindex='-1' aria-hidden='true'></a>Assistance Listing Number(s)
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93.859
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<a id='_bookmark261386' tabindex='-1' aria-hidden='true'></a>Funding Opportunity Purpose
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<p>This Notice of Funding Opportunity (NOFO) is for support of National Centers for Cryoelectron Tomography (CryoET) to provide nationwide access to advanced cryoET instrumentation and technical support, and to assist investigators in acquiring the skills needed to perform cryoET studies. </p>
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<a id='_bookmark261388' tabindex='-1' aria-hidden='true'></a>Funding Opportunity Goal(s)
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<p>The National Institute of General Medical Sciences (NIGMS) supports basic research that increases our understanding of biological processes and lays the foundation for advances in disease diagnosis, treatment, and prevention. NIGMS also supports research in specific clinical areas that affect multiple organ systems: anesthesiology and peri-operative pain; clinical pharmacology common to multiple drugs and treatments; and injury, critical illness, sepsis, and wound healing. NIGMS-funded scientists investigate how living systems work at a range of levels—from molecules and cells to tissues and organs—in research organisms, humans, and populations. Additionally, to ensure the vitality and continued productivity of the research enterprise, NIGMS provides leadership in supporting the training of future scientists and developing research capacity throughout the country.</p>
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<a id='_bookmark261389' tabindex='-1' aria-hidden='true'></a><a name="_Key Dates"></a><h2>Key Dates</h2>
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<a id='_bookmark261390' tabindex='-1' aria-hidden='true'></a>Posted Date
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February 05, 2026
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<a id='_bookmark261391' tabindex='-1' aria-hidden='true'></a>Open Date (Earliest Submission Date)
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February 10, 2026
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<th scope="col" colspan="3" style="border:2px solid #bcbcbc;" class="text-center">Application Due Dates</th>
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<th scope="col" style="width:16.66%;border-left:2px solid #bcbcbc;" class="text-center">New</th>
<th scope="col" style="width:16.66%" class="text-center">Renewal / Resubmission / Revision (as allowed)</th>
<th scope="col" style="width:16.66%;border-right:2px solid #bcbcbc;" class="text-center">AIDS - New/Renewal/Resubmission/Revision, as allowed</th>
<th scope="col" style="width:16.66%" class="text-center">Scientific Merit Review</th>
<th scope="col" style="width:16.66%" class="text-center">Advisory Council Review</th>
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March 10, 2026
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March 10, 2026
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Not Applicable
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<td>July 2026</td>
<td> October 2026

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<td>December 2026</td>
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January 26, 2027
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January 26, 2027
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Not Applicable
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<td>July 2027</td>
<td> October 2027

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<td>December 2027</td>
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<a id='_bookmark261395' tabindex='-1' aria-hidden='true'></a><p>All applications are due by 5:00 PM local time of applicant organization. </p>

<p>Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.</p>
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<a id='_bookmark261401' tabindex='-1' aria-hidden='true'></a>Expiration Date
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January 27, 2027
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<a id='_bookmark261402' tabindex='-1' aria-hidden='true'></a>Due Dates for E.O. 12372
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<p class="Normal">Not Applicable</p>
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<a id='_bookmark262221' tabindex='-1' aria-hidden='true'></a>Required Application Instructions
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<div data-element-id="262221" data-element-has-label="true" data-element-required="true" data-element-has-value="true" data-section-code="KD" data-element-type="TEXT">
<p>It is critical that applicants follow the instructions in the Research (R) Instructions in the <a href="https://grants.nih.gov/grants/guide/url_redirect.htm?id=82400">How to Apply - Application Guide</a>, except where instructed to do otherwise (in this NOFO or in a Notice from <a href="http://grants.nih.gov/grants/guide/url_redirect.htm?id=11164">NIH Guide for Grants and Contracts</a>).</p><p>Conformance to all requirements (both in the <a href="https://grants.nih.gov/grants/guide/url_redirect.htm?id=82400">How to Apply - Application Guide</a> and the NOFO) is required and strictly enforced. Applicants must read and follow all application instructions in the <a href="https://grants.nih.gov/grants/guide/url_redirect.htm?id=82400">How to Apply - Application Guide</a> as well as any program-specific instructions noted in Section IV. When the program-specific instructions deviate from those in the <a href="https://grants.nih.gov/grants/guide/url_redirect.htm?id=82400">How to Apply - Application Guide</a>, follow the program-specific instructions.</p><p><strong>Applications that do not comply with these instructions may be delayed or not accepted for review.</strong></p>
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<a id='_bookmark261403' tabindex='-1' aria-hidden='true'></a><p style="margin-left:0in;">There are several options available to submit your application through Grants.gov to NIH and Department of Health and Human Services partners. You <strong>must</strong> use one of these submission options to access the application forms for this opportunity.</p><ol><li>Use the <a href="https://public.era.nih.gov/assist/landing.era?tabId=0819b5fc-46b7-4f02-b6b7-127e5a4e19fa">NIH ASSIST system</a> to prepare, submit and track your application online.</li><li>Use an institutional system-to-system (S2S) solution to prepare and submit your application to Grants.gov and <a href="https://public.era.nih.gov/commons/">eRA Commons</a> to track your application. Check with your institutional officials regarding availability.</li><li>Use <a href="https://grants.gov/search-grants?oppStatuses=closed|archived|posted|forecasted&fon=PA-25-301">Grants.gov</a> Workspace to prepare and submit your application and <a href="http://public.era.nih.gov/commons/">eRA Commons</a> to track your application.</li></ol>
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<div id="tocDiv">
<div class="heading1" tabindex="0">Table of Contents</div>
<div class="toc-link"><a href="#_Part1.OverviewInformation">Part 1. Overview Information</a></div><div class="toc-link P_SingleIndent"><a href="#_KeyDates">Key Dates</a></div><div class="toc-link"><a href="#_Part2.FullTextofAnnouncement">Part 2. Full Text of Announcement</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionI.NoticeofFundingOpportunityDescription">Section I. Notice of Funding Opportunity Description</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionII.AwardInformation">Section II. Award Information</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionIII.EligibilityInformation">Section III. Eligibility Information</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionIV.ApplicationandSubmissionInformation">Section IV. Application and Submission Information</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionV.ApplicationReviewInformation">Section V. Application Review Information</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionVI.AwardAdministrationInformation">Section VI. Award Administration Information</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionVII.AgencyContacts">Section VII. Agency Contacts</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionVIII.OtherInformation">Section VIII. Other Information</a></div>
</div><br/>

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<a id='_bookmark261405' tabindex='-1' aria-hidden='true'></a><a name="_Part 2. Full Text of Announcement"></a><h1>Part 2. Full Text of Announcement</h1>
</div>

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<a id='_bookmark261406' tabindex='-1' aria-hidden='true'></a><a name="_Section I. Notice of Funding Opportunity Description"></a><h2>Section I. Notice of Funding Opportunity Description</h2>
</div>

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<a id='_bookmark261407' tabindex='-1' aria-hidden='true'></a><h4 style="margin-left:0px;">Background</h4><p style="margin-left:0px;">Technical advances in single particle cryoelectron microscopy (cryoEM) have enabled generation of reliable atomic models of complete and fully functional macromolecular complexes. NIGMS currently supports three National Centers that provide technical training in and access to instrumentation for single particle cryoEM analysis of purified samples. In cryoET, a related method, recent advances in sample preparation, electron optics, detectors, and image processing enable determination of macromolecular complex structures in unstained frozen cells. However, the high cost of microscopes and supporting instrumentation for specimen preparation present barriers to the broad utilization of cryoET. This program will support centers to provide access to instruments for sample preparation and cryoET data collection. Additionally, because the workflows for specimen preparation are complex and technically challenging, the cryoET centers will provide training in sample preparation and collecting tomographic data.</p><h4 style="margin-left:0px;">Program Objectives</h4><p style="margin-left:0px;">This program will support service centers for nationwide access to state-of-the-art cryoET technology, expertise, and training. A goal of this program is to increase national expertise in cryoET; service centers will therefore prioritize training users to work independently rather than focusing on only providing user service. </p><p style="margin-left:0px;">The primary objectives of the centers are to provide:</p><ul><li>Access to state-of-the-art facilities for cryoET</li><li>User training in the theory and practice of cryoET</li><li>Assistance in sample preparation and tomographic data collection </li></ul><h4 style="margin-left:0px;">Facility Requirements</h4><p style="margin-left:0px;">Each center must have:</p><ul><li>At least one cryogenic focused ion beam-scanning electron microscope (cryo-FIB-SEM) reserved for the sole use of the center</li><li>At least one state-of-the-art 300keV cryoEM microscope equipped with a direct electron detector reserved for the sole use of the center</li><li>Equipment for correlative light and electron microscopy (CLEM) reserved for the sole use of the center</li><li>Bench space and equipment for specimen preparation, including for biochemistry, handling of cells and tissues, and plunge and high-pressure freezing</li><li>Computational resources for standard initial processing and correction of raw image data, for standard calculation of tomographic density maps, and for short-term image storage</li><li>A web-based resource to facilitate remote user access to instruments and data</li></ul><p style="margin-left:0px;">Both the cryo-FIB-SEM and a 300keV microscope must be at one site. Centers proposing to incorporate more than one cryo-FIB-SEM or one 300keV electron microscope must justify the need for multiple instruments within the goals of the center. Microscopes that are currently part of a federally-funded resource or center must remain assigned to the relevant active award.</p><h4 style="margin-left:0px;">Service Requirements</h4><p style="margin-left:0px;">The scope of this initiative is limited to analysis of native, frozen-hydrated biological specimens using 3-D (tomographic) transmission electron microscopy. Other emerging technologies, for example those using embedded specimens and/or scanning electron microscopy, while important, are outside the scope of the initiative and should not be offered.</p><p style="margin-left:0px;"><strong>Specimen Preparation. </strong>The centers technical staff will work with user laboratories to prepare specimens for cryoET using standard or user-provided protocols. Methods may include plunge freezing, high-pressure freezing, CLEM, or cryo-FIB-SEM milling. Center staff will supervise and assist on-site users and may work with these users to customize preparation methods for particular specimens, as required. Provision must be made for users to participate remotely to supervise and direct workflow as needed.</p><p style="margin-left:0px;"><strong>Tomographic Data Collection. </strong>Center staff will collect cryoET data on samples prepared at the center or elsewhere.</p><p style="margin-left:0px;"><strong>Data Processing. </strong>The center will provide standard initial processing and correction of raw image data and standard calculation of tomographic density maps if requested by users but will not perform project-specific analyses. The center will provide short-term storage and efficient transfer of users' cryoET data, with users responsible for their own long-term data storage.</p><p style="margin-left:0px;"><strong>Training. </strong>The center will offer training to user laboratories in the general theory and practice of cryoET methods. Users may be trained to operate equipment on their own, on site, or remotely. Such training should cover the basic skills laboratories need to undertake their own independent cryoET specimen preparation.</p><p style="margin-left:0px;"><strong>Center Research. </strong>The center may engage in research that directly advances its service objectives. Centers are expected to keep pace with advances in practice by implementing new protocols into their workflows. The center will adapt outside developers' protocols into robust and reproducible workflows and implement them as standard services. Centers may develop technology to improve their data collection capabilities during the approved project period. No more than 10% of center effort may be invested in integrating new technology. Technology development that does not directly advance the center's service objectives is beyond the scope of this NOFO and may be supported through other sources of funding such as the NIGMS Technology Development Programs R21 (<a href="https://grants.nih.gov/grants/guide/pa-files/PAR-25-202.html"><u>PAR-25-202</u></a>) and R01 (<a href="https://grants.nih.gov/grants/guide/pa-files/PAR-25-203.html"><u>PAR-25-203</u></a>).</p><h4 style="margin-left:0px;">Administrative Requirements</h4><p style="margin-left:0px;"><strong>User Application and Review Process</strong>. Applications for center access should be prioritized through a formal scientific review process by a User Review Committee as well as programmatic and administrative review by center staff. The review process for instrument usage and training should be consistent with the objectives of equal opportunity and nationwide access to state-of-the-art cryoET equipment, technical support, and training.</p><p style="margin-left:0px;">There should be a single, public application track for all users, including local and institutional users. Except for the center's own internal development, quality control, maintenance, and evaluation projects, other institutional or local use must be reviewed and prioritized through the same public channels as all other users.</p><p style="margin-left:0px;"><strong>User Charges. </strong>There will be no facility charges for users from non-profit institutions.</p><p style="margin-left:0px;"><strong>User Accommodation. </strong>Information should be provided to users about local lodging, meals, and transportation available at reasonable cost.</p><p style="margin-left:0px;"><strong>Staffing. </strong>Since professional effort on center appointments will be mainly service-related activities, centers are encouraged to develop strategies for the recruitment and development of highly qualified staff. Center personnel with part-time appointments may participate in research outside of the center, provided their effort on this research is supported by other funding sources. Center staff must apply as users through the center's public application process for use of center facilities for their outside research.</p><p style="margin-left:0px;"><strong>Website and Information Sharing Activities.</strong> The center is expected to inform the scientific community of their capabilities and services, promote broader application of cryoET, and actively recruit users. The center must have a website that provides up-to-date and complete information about facilities and services, policies, and the application process. The center must also engage in active outreach.</p><p style="margin-left:0px;"><strong>Partnerships.</strong> The center may form partnerships that advance its mission. Examples include, but are not limited to, partnerships with instrumentation manufacturers/vendors and collaboration with academic technology developers.</p><p style="margin-left:0px;"><strong>Center-to-Center Coordination.</strong> Centers funded through this NOFO are encouraged to coordinate on:Providing backup for service interruptions</p><ul><li>User application reviews</li><li>Sharing websites, best practices and newly developed technologies</li><li>Developing and cross-honoring training certifications in standard practices</li></ul><p style="margin-left:0px;"><strong>Data and Data Sharing. </strong>Center users, not the center itself, are responsible for long-term storage of any data generated from user samples. As a condition of center services, users must agree to follow all applicable NIH policies for the sharing of their data and research resources, as appropriate.</p><p style="margin-left:0px;"><strong>Advisory Committee. </strong>The use of an Advisory Committee for the center is optional and may not involve NIH personnel.</p><p style="margin-left:0px;"><strong>Record Keeping and Progress Reviews. </strong>Centers should keep records to track activities, applications, users, specimens, microscope usage, outcomes, and user feedback. They should be kept current and accessible for review by the PD(s)/PI(s) and summarized in the annual progress reports. A records system should be used to track progress for the following items:</p><ul><li><i>Applications and Review</i>.  Types and numbers of applications received, review evaluations, and outcomes.</li><li><i>User Base</i>.  Users served (persons visiting, institutional affiliation, career level, instrument time allocation). Type of project (sample preparation, data collection, training).  Breakout of visits (in person, remote, mail-in).  Geographic distribution.</li><li><i>Service summaries</i>.  Types of services provided.  Sample preparation (FIB-Milling, CLEM).  Data collection (number of projects, number/size of data sets) and outcomes (quantity/resolution, usability, status).  Training (number of projects, visit type, topics covered, certifications received).</li><li><i>Microscope use</i>.  Log of hours for each microscope (electron microscopes, cryo-FIB-SEM, cryo-light microscope) for: Center usage, Idle time, Time unavailable (repair/downtime, holidays, etc.).</li><li><i>Workshop training</i>.  Dates, location, and topics of workshops.  Number of attendees, in-person, virtual, hands-on access.  Evaluation outcomes. </li></ul><h4 style="margin-left:0px;"><strong>Non-Responsiveness Criteria</strong></h4><p style="margin-left:0px;">The following types of applications are non-responsive to this NOFO and will be withdrawn without review:</p><ul><li>Applications from institutions with insufficient instrumentation for the proposed center according to specifications listed under Facility Requirements.</li><li>Applications from institutions where the cryo-FIB-SEM and the 300keV cryoEM microscope are located at different sites.</li></ul><p style="margin-left:0px;">Due to the NOFOs restricted scope, special application instructions, and additional review criteria, potential applicants are strongly advised to discuss their plans with the Scientific/Research contact listed in Section VII prior to submitting an application.</p>
</div>

<div data-element-id="261410" data-element-has-label="false" data-element-required="true" data-element-has-value="true" data-section-code="FOD" data-element-type="TEXT">
<a id='_bookmark261410' tabindex='-1' aria-hidden='true'></a><p>See <a href="#_Section_VIII._Other">Section VIII. Other Information</a> for award authorities and regulations.</p>
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<a id='_bookmark261411' tabindex='-1' aria-hidden='true'></a><a name="_Section II. Award Information"></a><h2>Section II. Award Information</h2>
</div>

<div class="row" data-index="40">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="261412" data-element-required="true" data-element-has-value="true" data-section-code="AI" data-element-type="TEXT">
<a id='_bookmark261412' tabindex='-1' aria-hidden='true'></a>Funding Instrument
</div>
<div class=" col-md-8 datacolumn">
<p>Grant: A financial assistance mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity.</p>
</div>
</div>

<div class="row" data-index="41">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="261413" data-element-required="true" data-element-has-value="true" data-section-code="AI" data-element-type="LINKED_ELEMENT">
<a id='_bookmark261413' tabindex='-1' aria-hidden='true'></a> Application Types Allowed
</div>
<div class=" col-md-8 datacolumn">
New
<br>
Revision
<br>
</div>
</div>

<div class="row" data-index="43">
<div class="col-md-push-4 col-md-8 datacolumn">
<a id='_bookmark261415' tabindex='-1' aria-hidden='true'></a><p>The <a href="http://grants.nih.gov/grants/guide/url_redirect.htm?id=11116">OER Glossary</a> and the <a href="https://grants.nih.gov/grants/guide/url_redirect.htm?id=82400">How to Apply - Application Guide</a> provide details on these application types. Only those application types listed here are allowed for this NOFO.</p>
</div>
</div>

<div class="row" data-index="44">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="261416" data-element-required="false" data-element-has-value="true" data-section-code="AI" data-element-type="TEXT">
<a id='_bookmark261416' tabindex='-1' aria-hidden='true'></a>Clinical Trial?
</div>
<div class=" col-md-8 datacolumn">
<p>Not Allowed: Only accepting applications that do not propose clinical trials.</p>
</div>
</div>

<div class="row" data-index="45">
<div class="col-md-push-4 col-md-8 datacolumn">
<a id='_bookmark261417' tabindex='-1' aria-hidden='true'></a><p><a href="https://grants.nih.gov/grants/guide/url_redirect.htm?id=82370">Need help determining whether you are doing a clinical trial?</a></p>
</div>
</div>

<div class="row" data-index="46">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="261418" data-element-required="true" data-element-has-value="true" data-section-code="AI" data-element-type="TEXT">
<a id='_bookmark261418' tabindex='-1' aria-hidden='true'></a>Funds Available and Anticipated Number of Awards
</div>
<div class=" col-md-8 datacolumn">
<p>The number of awards is contingent upon NIH appropriations and the number of meritorious applications.</p>
</div>
</div>

<div class="row" data-index="47">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="261419" data-element-required="true" data-element-has-value="true" data-section-code="AI" data-element-type="TEXT">
<a id='_bookmark261419' tabindex='-1' aria-hidden='true'></a>Award Budget
</div>
<div class=" col-md-8 datacolumn">
<p>Application budgets are not limited but must reflect the actual needs of the proposed project.</p>
</div>
</div>

<div class="row" data-index="48">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="261420" data-element-required="true" data-element-has-value="true" data-section-code="AI" data-element-type="TEXT">
<a id='_bookmark261420' tabindex='-1' aria-hidden='true'></a>Award Project Period
</div>
<div class=" col-md-8 datacolumn">
<p>The maximum project period is 5 years.</p>
</div>
</div>

<div data-element-id="261421" data-element-has-label="false" data-element-required="true" data-element-has-value="true" data-section-code="AI" data-element-type="TEXT">
<a id='_bookmark261421' tabindex='-1' aria-hidden='true'></a><p>NIH grants policies as described in the <a href="http://grants.nih.gov/grants/guide/url_redirect.htm?id=11120">NIH Grants Policy Statement</a> will apply to the applications submitted and awards made from this NOFO.</p>
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<a id='_bookmark261422' tabindex='-1' aria-hidden='true'></a><a name="_Section III. Eligibility Information"></a><h2>Section III. Eligibility Information</h2>
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<a id='_bookmark261423' tabindex='-1' aria-hidden='true'></a><h4>1. Eligible Applicants</p>
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<a id='_bookmark261424' tabindex='-1' aria-hidden='true'></a>Eligible Organizations
</div>

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<p>Higher Education Institutions - Includes all types</p><ul><li>Public/State Controlled Institutions of Higher Education</li><li>Private Institutions of Higher Education</li></ul><p>Nonprofits Other Than Institutions of Higher Education</p><ul><li>Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Higher Education)</li><li>Nonprofits without 501(c)(3) IRS Status (Other than Institutions of Higher Education)</li></ul><p>For-Profit Organizations</p><ul><li>Small Businesses</li><li>For-Profit Organizations (Other than Small Businesses)</li></ul><p>Local Governments</p><ul><li>State Governments</li><li>County Governments</li><li>City or Township Governments</li><li>Special District Governments</li><li>Indian/Native American Tribal Governments (Federally Recognized)</li><li>Indian/Native American Tribal Governments (Other than Federally Recognized)</li></ul>
</div>

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<a id='_bookmark261425' tabindex='-1' aria-hidden='true'></a><p>Federal Governments</p>

<ul>
<li>Eligible Agencies of the Federal Government</li>
<li>U.S. Territory or Possession</li>
</ul>
</div>

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<a id='_bookmark261426' tabindex='-1' aria-hidden='true'></a><p>Other</p>

<ul>
<li>Independent School Districts</li>
<li>Public Housing Authorities/Indian Housing Authorities</li>
<li>Native American Tribal Organizations (other than Federally recognized tribal governments)</li>
<li>Faith-based or Community-based Organizations</li>
<li>Regional Organizations</li>
</ul>
</div>

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<a id='_bookmark261428' tabindex='-1' aria-hidden='true'></a><h4>Foreign Organizations/Foreign Collaborations</h4>
</div>

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<a id='_bookmark261429' tabindex='-1' aria-hidden='true'></a><p class="Normal">Non-domestic (non-U.S.) Entities (Foreign Organizations) <strong>are not</strong> eligible to apply.</p>
</div>

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<a id='_bookmark261430' tabindex='-1' aria-hidden='true'></a><p>Non-domestic (non-U.S.) components of U.S. Organizations <strong>are not</strong> eligible to apply.</p>
</div>

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<a id='_bookmark261431' tabindex='-1' aria-hidden='true'></a><p>Foreign components, as <a href="http://grants.nih.gov/grants/guide/url_redirect.htm?id=11118">defined in the <em>NIH Grants Policy Statement</em></a>, <strong>are not</strong> allowed. </p>
</div>

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<a id='_bookmark261432' tabindex='-1' aria-hidden='true'></a>Required Registrations
</div>

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<p><strong>Applicant Organizations</strong></p>

<p>Applicant organizations must complete and maintain the following registrations as described in the <a href="https://grants.nih.gov/grants/guide/url_redirect.htm?id=82400">How to Apply - Application Guide</a> to be eligible to apply for or receive an award. All registrations must be completed prior to the application being submitted. Registration can take 6 weeks or more, so applicants should begin the registration process as soon as possible. Failure to complete registrations in advance of a due date is not a valid reason for a late submission, please reference <a href="http://grants.nih.gov/grants/guide/url_redirect.htm?id=82423">NIH Grants Policy Statement Section 2.3.9.2 Electronically Submitted Applications</a> for additional information</p>

<ul>
<li><a href="https://grants.nih.gov/grants/guide/url_redirect.htm?id=82390">System for Award Management (SAM) –</a> Applicants must complete and maintain an active registration, <strong>which requires renewal at least annually</strong>. The renewal process may require as much time as the initial registration. SAM registration includes the assignment of a Commercial and Government Entity (CAGE) Code for domestic organizations which have not already been assigned a CAGE Code.

<ul>
<li><a href="http://grants.nih.gov/grants/guide/url_redirect.htm?id=11176">NATO Commercial and Government Entity (NCAGE) Code</a> – Foreign organizations must obtain an NCAGE code (in lieu of a CAGE code) in order to register in SAM.</li>
<li>Unique Entity Identifier (UEI) - A UEI is issued as part of the SAM.gov registration process. The same UEI must be used for all registrations, as well as on the grant application.</li>
</ul>
</li>
<li><a href="https://grants.nih.gov/grants/guide/url_redirect.htm?id=11123">eRA Commons</a> - Once the unique organization identifier is established, organizations can register with eRA Commons in tandem with completing their Grants.gov registrations; all registrations must be in place by time of submission. eRA Commons requires organizations to identify at least one Signing Official (SO) and at least one Program Director/Principal Investigator (PD/PI) account in order to submit an application.</li>
<li><a href="http://grants.nih.gov/grants/guide/url_redirect.htm?id=82300">Grants.gov</a> – Applicants must have an active SAM registration in order to complete the Grants.gov registration.</li>
</ul>

<p><strong>Program Directors/Principal Investigators (PD(s)/PI(s))</strong></p>

<p>All PD(s)/PI(s) must have an eRA Commons account.  PD(s)/PI(s) should work with their organizational officials to either create a new account or to affiliate their existing account with the applicant organization in eRA Commons. If the PD/PI is also the organizational Signing Official, they must have two distinct eRA Commons accounts, one for each role. Obtaining an eRA Commons account can take up to 2 weeks.</p>
</div>

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<a id='_bookmark261433' tabindex='-1' aria-hidden='true'></a>Eligible Individuals (Program Director/Principal Investigator)
</div>

<div data-element-id="261433" data-element-has-label="true" data-element-required="true" data-element-has-value="true" data-section-code="EI" data-element-type="TEXT">
<p>Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with their organization to develop an application for support. </p><p>For institutions/organizations proposing multiple PDs/PIs, visit the Multiple Program Director/Principal Investigator Policy and submission details in the Senior/Key Person Profile (Expanded) Component of the <a href="https://grants.nih.gov/grants/guide/url_redirect.htm?id=82400">How to Apply - Application Guide</a>.</p>
</div>

<div data-element-id="261434" data-element-has-label="false" data-element-required="false" data-element-has-value="true" data-section-code="EI" data-element-type="TEXT">
<a id='_bookmark261434' tabindex='-1' aria-hidden='true'></a><p>At least one PD/PI should be an expert in cryoET and at least one PD/PI should have experience managing a scientific resource. These roles can be filled by the same person. </p>
</div>

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<a id='_bookmark261435' tabindex='-1' aria-hidden='true'></a><h4>2. Cost Sharing</h4><p>This NOFO does not require cost sharing as defined in the <a href="http://grants.nih.gov/grants/guide/url_redirect.htm?id=11126">NIH Grants Policy Statement NIH Grants Policy Statement Section 1.2 Definition of Terms.</a></p>
</div>

<div data-element-id="261436" data-element-has-label="false" data-element-required="true" data-element-has-value="true" data-section-code="EI" data-element-type="TEXT">
<a id='_bookmark261436' tabindex='-1' aria-hidden='true'></a><h4>3. Additional Information on Eligibility</h4><p>Number of Applications</p>
</div>

<div data-element-id="261437" data-element-has-label="false" data-element-required="true" data-element-has-value="true" data-section-code="EI" data-element-type="TEXT">
<a id='_bookmark261437' tabindex='-1' aria-hidden='true'></a><p>Applicant organizations may submit more than one application, provided that each application is scientifically distinct.</p><p>The NIH will not accept duplicate or highly overlapping applications under review at th

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Focus Areas & Funding Uses

Fields of Work

$2,000,000 - $5,000,000

Deadline

April 13, 2026

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National Centers for Cryo-electron Tomography (cryoET) (R24 -Clinical Trial Not Allowed)

Overview

National Centers for Cryo-electron Tomography (cryoET) (R24 -Clinical Trial Not Allowed)

Details

Eligibility

Eligibility

Eligible Applicant Types

How to Apply

PAR-26-138-Full-Announcement.html

Focus Areas & Funding Uses

Fields of Work

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