Improving Methods for Conducting Patient - Centered Comparative Clinical Effectiveness Research PCORI Funding Announcement - Cycle 1 Grant

The Patient-Centered Outcomes Research Institute (PCORI) Funding Announcement aims to enhance methods for conducting patient-centered comparative clinical effectiveness research. This initiative seeks to address critical methodological gaps, focusing on improving the use of artificial intelligence in clinical research, study design, data research networks, and ethical protections in patient-centered CER. With a budget of up to $750,000, successful proposals will contribute to the quality and strength of evidence generated in CER studies.

Improving Methods for Conducting Patient-Centered Comparative Clinical Effectiveness Research PCORI Funding Announcement - Cycle 1
With this PCORI Funding Announcement (PFA), PCORI aims to fund studies that address high-priority methodological gaps in patient-centered comparative clinical effectiveness research (CER).
For the Cycle 1 2026 Methods PFA, PCORI has identified the following areas that address important methodological gaps and lead to improvements in the strength and quality of evidence generated by CER studies:
Methods to Improve the Use of Artificial Intelligence (AI) and Machine Learning (ML) in Clinical Research  Methods to Improve Study Design  Methods to Support Data Research Networks  Methods Related to Ethical and Human Subjects Protections Issues in patient-centered CER
Up to three years
At the time of contract execution, PCORI sets aside the funds associated with an awarded project to be made available throughout the contract’s period of performance. The maximum budget includes all research- and peer review–related costs. This PFA does not consider exceptions to the budget.