Early-Stage Dissemination and Implementation Research in Communication Disorders (R21 Clinical Trial Optional)
National Institutes of Health
Funding Amount
$1,000,000 total
Deadline
June 17, 2027
434 days left
Grant Type
federal
Overview
Early-Stage Dissemination and Implementation Research in Communication Disorders (R21 Clinical Trial Optional)
The National Institute on Deafness and other Communication Disorders (NIDCD) intends to re-issue a Notice of Funding Opportunity (NOFO, prior funding opportunity RFA-DC-24-008 to solicit applications for research on early-stage dissemination and implementation (D&I) in the NIDCD mission areas of hearing, balance, taste, smell, voice, speech, and language. Much research is devoted to developing evidence-based innovations (EBIs) that improve a person"s health and quality of life. To impact people"s lives, EBIs need to be adopted in clinical practice and everyday life. Unfortunately, wide-scale adoption of EBIs is lengthy and rare. Dissemination and implementation (D&I) science is the field of research that seeks to close the gap between research and practice. Dissemination research is defined as the scientific study of the targeted distribution of information and materials about EBI to a specific audience (e.g., practitioners, patients, policymakers). The intent is to understand how best to communicate and integrate knowledge associated with a given EBI. Implementation Science refers to a broader array of active and planned efforts to integrate evidence into practice. Implementation research focuses on understanding why clinical and community settings are not adopting and sustaining a particular EBI. In turn, implementation research uses this understanding of barriers and facilitators to develop and evaluate different strategies (or collections of strategies) to increase adoption and integration of an EBI into practice. Many fields have applied D&I research theories, approaches, and outcome measures to improve adoption and sustainment of EBIs. This funding opportunity aims to support early-stage D&I research in NIDCD mission areas of hearing, balance, taste, smell, voice, speech, and language. Resulting findings should set a sufficient foundation for a high-quality, D&I focused R01 in NIDCD mission areas. Applications are not being solicited at this time. Notice is be
Details
- Agency: National Institutes of Health
- Department: Department of Health and Human Services
- Opportunity #: RFA-DC-26-001
- Total Funding: $1,000,000
- Instrument: grant
Eligibility
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.NIH will no longer issue awards (i.e., new, renewal, or non-competing continuation) to domestic or foreign entities that involve foreign subawards/subcontracts. All NIH-funded research involving foreign subawards/subcontracts must be submitted in response to a NOFO that is specifically designated for funded international collaborations. This new requirement was effective, May 1, 2025.Applications involving foreign subawards/subcontracts submitted in response to this NOFO will be deemed noncompliant and will not be considered for funding. This policy applies to all monetary international collaborations resu
Eligibility
Eligible Applicant Types
How to Apply
RFA-DC-26-001-Full-Announcement.html
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<title>RFA-DC-26-001: Early-Stage Dissemination and Implementation Research in Communication Disorders (R21 Clinical Trial Optional)</title>
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<div id="page-title" class="heading1" tabindex="0">Department of Health and Human Services</div>
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<a id='_bookmark261213' tabindex='-1' aria-hidden='true'></a><a name="_Part 1. Overview Information"></a><h1>Part 1. Overview Information</h1>
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<a id='_bookmark261214' tabindex='-1' aria-hidden='true'></a>Participating Organization(s)
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<p>National Institutes of Health (<a href="http://www.nih.gov">NIH</a>)</p>
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<a id='_bookmark261216' tabindex='-1' aria-hidden='true'></a>Components of Participating Organizations
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<p>National Institute on Deafness and Other Communication Disorders (<a href="https://www.nidcd.nih.gov/" target="_blank" rel="noreferrer">NIDCD</a>)
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<a id='_bookmark261218' tabindex='-1' aria-hidden='true'></a>Funding Opportunity Title
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<span class="title">Early-Stage Dissemination and Implementation Research in Communication Disorders (R21 Clinical Trial Optional)</span>
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<a id='_bookmark261219' tabindex='-1' aria-hidden='true'></a>Activity Code
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<p><a href="http://grants.nih.gov/grants/funding/ac_search_results.htm?text_curr=r21&Search.x=0&Search.y=0&Search_Type=Activity">R21</a> Exploratory/Developmental Research Grant</p>
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<a id='_bookmark261220' tabindex='-1' aria-hidden='true'></a>Announcement Type
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Reissue of
RFA-DC-24-008
<br/>
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<a id='_bookmark261221' tabindex='-1' aria-hidden='true'></a>Related Notices
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<ul><li>Check for any recent <a href="https://grants.nih.gov/grants/guide/url_redirect.php?id=11163">Notices of NIH Policy Changes</a> that may impact application requirements.</li></ul>
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<a id='_bookmark261222' tabindex='-1' aria-hidden='true'></a>Funding Opportunity Number (FON)
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<span class="noticenum">RFA-DC-26-001</span>
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<a id='_bookmark261223' tabindex='-1' aria-hidden='true'></a>Companion Funding Opportunity
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None
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<a id='_bookmark261224' tabindex='-1' aria-hidden='true'></a>Number of Applications
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<p>See Part 2, Section III. 3. Additional Information on Eligibility.</p>
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<a id='_bookmark261225' tabindex='-1' aria-hidden='true'></a>Assistance Listing Number(s)
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93.173
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<a id='_bookmark261226' tabindex='-1' aria-hidden='true'></a>Funding Opportunity Purpose
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<p>NIDCD invites applications for early-stage dissemination and implementation (D&I) research projects (e.g., during development and evaluation of the evidence-based innovation, EBI) in the NIDCD mission areas of hearing, balance, taste, smell, voice, speech, and language.</p>
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<a id='_bookmark261228' tabindex='-1' aria-hidden='true'></a>Funding Opportunity Goal(s)
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<p>To investigate solutions to problems directly relevant to individuals with deafness or disorders of human communication in the areas of hearing, balance, smell, taste, voice, speech, and language. The National Institute on Deafness and Other Communication Disorders (NIDCD) supports research and research training, including investigation into the etiology, pathology, detection, treatment, and prevention of disorders of hearing and other communication processes, primarily through the support of basic and applied research in anatomy, audiology, biochemistry, bioengineering, epidemiology, genetics, immunology, microbiology, molecular biology, the neurosciences, otolaryngology, psychology, pharmacology, physiology, psychophysics, speech-language pathology, and other scientific disciplines. The NIDCD supports: (1) Research into the evaluation of techniques and devices used in diagnosis, treatment, rehabilitation, and prevention of disorders of hearing and other communication processes; (2) research into prevention and early detection and diagnosis of hearing loss and speech, voice, and language disorders and research into preventing the effects of such disorders by means of appropriate referral and rehabilitation; (3) research into the detection, treatment, and prevention of disorders of hearing and other communication processes in the elderly population and its rehabilitation to ensure continued effective communication skills; and (4) research to expand knowledge of the effects of environmental agents that influence hearing or other communication processes. </p>
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<a id='_bookmark261229' tabindex='-1' aria-hidden='true'></a><a name="_Key Dates"></a><h2>Key Dates</h2>
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February 05, 2026
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May 18, 2026
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<th scope="col" style="width:16.66%;border-left:2px solid #bcbcbc;" class="text-center">New</th>
<th scope="col" style="width:16.66%" class="text-center">Renewal / Resubmission / Revision (as allowed)</th>
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June 18, 2026
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June 18, 2026
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<td>November 2026</td>
<td> January 2027
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<td>April 2027</td>
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June 17, 2027
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June 17, 2027
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Not Applicable
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<td>November 2027</td>
<td> January 2028
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<td>April 2028</td>
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<a id='_bookmark261235' tabindex='-1' aria-hidden='true'></a><p>All applications are due by 5:00 PM local time of applicant organization. </p>
<p>Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.</p>
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<a id='_bookmark261236' tabindex='-1' aria-hidden='true'></a><p class="Normal">No late applications will be accepted for this Notice of Funding Opportunity (NOFO).</p>
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<p>Not Applicable</p>
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June 18, 2027
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<p>It is critical that applicants follow the instructions in the Research (R) Instructions in the <a href="https://grants.nih.gov/grants/guide/url_redirect.htm?id=82400">How to Apply - Application Guide</a>, except where instructed to do otherwise (in this NOFO or in a Notice from <a href="http://grants.nih.gov/grants/guide/url_redirect.htm?id=11164">NIH Guide for Grants and Contracts</a>).</p>
<p>Conformance to all requirements (both in the Application Guide and the NOFO) is required and strictly enforced. Applicants must read and follow all application instructions in the Application Guide as well as any program-specific instructions noted in Section IV. When the program-specific instructions deviate from those in the Application Guide, follow the program-specific instructions.</p>
<p><strong>Applications that do not comply with these instructions may be delayed or not accepted for review.</strong></p>
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<a id='_bookmark262235' tabindex='-1' aria-hidden='true'></a><p style="margin-left:0in;">There are several options available to submit your application through Grants.gov to NIH and Department of Health and Human Services partners. You <strong>must</strong> use one of these submission options to access the application forms for this opportunity.</p><ol><li>Use the <a href="https://public.era.nih.gov/assist/landing.era?tabId=0819b5fc-46b7-4f02-b6b7-127e5a4e19fa">NIH ASSIST system</a> to prepare, submit and track your application online.</li><li>Use an institutional system-to-system (S2S) solution to prepare and submit your application to Grants.gov and <a href="https://public.era.nih.gov/commons/">eRA Commons</a> to track your application. Check with your institutional officials regarding availability.</li><li>Use <a href="https://grants.gov/search-grants?oppStatuses=closed|archived|posted|forecasted&fon=PA-25-301">Grants.gov</a> Workspace to prepare and submit your application and <a href="http://public.era.nih.gov/commons/">eRA Commons</a> to track your application.</li></ol>
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<div id="tocDiv">
<div class="heading1" tabindex="0">Table of Contents</div>
<div class="toc-link"><a href="#_Part1.OverviewInformation">Part 1. Overview Information</a></div><div class="toc-link P_SingleIndent"><a href="#_KeyDates">Key Dates</a></div><div class="toc-link"><a href="#_Part2.FullTextofAnnouncement">Part 2. Full Text of Announcement</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionI.NoticeofFundingOpportunityDescription">Section I. Notice of Funding Opportunity Description</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionII.AwardInformation">Section II. Award Information</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionIII.EligibilityInformation">Section III. Eligibility Information</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionIV.ApplicationandSubmissionInformation">Section IV. Application and Submission Information</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionV.ApplicationReviewInformation">Section V. Application Review Information</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionVI.AwardAdministrationInformation">Section VI. Award Administration Information</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionVII.AgencyContacts">Section VII. Agency Contacts</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionVIII.OtherInformation">Section VIII. Other Information</a></div>
</div><br/>
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<a id='_bookmark261245' tabindex='-1' aria-hidden='true'></a><a name="_Part 2. Full Text of Announcement"></a><h1>Part 2. Full Text of Announcement</h1>
</div>
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<a id='_bookmark261246' tabindex='-1' aria-hidden='true'></a><a name="_Section I. Notice of Funding Opportunity Description"></a><h2>Section I. Notice of Funding Opportunity Description</h2>
</div>
<div data-element-id="261247" data-element-has-label="false" data-element-required="true" data-element-has-value="true" data-section-code="FOD" data-element-type="TEXT">
<a id='_bookmark261247' tabindex='-1' aria-hidden='true'></a><p style="margin-left:0px;"><strong>Background</strong></p><p style="margin-left:0px;">Much research is devoted to developing evidence-based innovations (EBIs) that improve a person’s health and quality of life. To impact people’s lives, EBIs need to be adopted in clinical practice and everyday life. Unfortunately, wide-scale adoption of EBIs is lengthy and rare. Dissemination and implementation (D&I) science is the field of research that seeks to close the gap between research and practice. <i>Dissemination</i> research is defined as the scientific study of the targeted distribution of information and materials about EBI to a specific audience (e.g., practitioners, patients, policymakers). The intent is to understand how best to communicate and integrate knowledge associated with a given EBI. <i>Implementation Science</i> refers to a broader array of active and planned efforts to integrate evidence into practice. Implementation research focuses on understanding why clinical and community settings are not adopting and sustaining a particular EBI. In turn, implementation research uses this understanding of barriers and facilitators to develop and evaluate different strategies (or collections of strategies) to increase adoption and integration of an EBI into practice. Many fields have applied D&I research theories, approaches, and outcome measures to improve adoption and sustainment of EBIs.</p><p style="margin-left:0px;">To better understand the landscape of D&I in NIDCD mission areas, a <a href="https://www.nidcd.nih.gov/news/events/dissemination-implementation-science-communication-disorders-virtual-workshop">2-day virtual workshop</a> was held on October 24-25, 2023. One insight from this workshop was the need to increase early-stage D&I research at the start of clinical research (e.g., during development and evaluation of the EBI) to set a solid foundation for later, high-quality, D&I-focused research. That is, there is a need to create readiness for D&I research early in the translational research pipeline, including activities such as building collaborative partnerships, understanding the context for disseminating and implementing the EBI, and evaluating preliminary D&I strategies using D&I outcome measures.</p><p style="margin-left:0px;">This funding opportunity aims to support early-stage D&I research (e.g., during development and evaluation of the EBI) in NIDCD mission areas of hearing, balance, taste, smell, voice, speech, and language. Resulting findings should set a sufficient foundation for a high-quality, D&I focused R01 in NIDCD mission areas.</p><p style="margin-left:0px;"><strong>Required Elements</strong></p><p style="margin-left:0px;">Given the focus of this funding opportunity on creating readiness for future, high-quality, D&I focused research, investigators are required to integrate a D&I process model (<a href="https://implementationscience.biomedcentral.com/articles/10.1186/s13012-015-0242-0">Nilsen, 2015</a>) as a core component of their application. D&I process models outline activities that need to be accomplished at different points in the research process to set the foundation for subsequent activities, moving efficiently through the various stages of translational research. Many process models include a description of activities that should be accomplished prior to D&I research (e.g., Getting-to-Outcomes, Active Implementation, Quality Implementation Framework, EPIS-Exploration-Preparation-Implementation-Sustainment, Intervention Mapping, Knowledge-to-Action). No specific model is required for this funding opportunity. Investigators should select a D&I process model that is appropriate for their current and future translational research goals. Applicants are highly encouraged to consult with a D&I expert in identifying and applying an appropriate D&I process model.</p><p style="margin-left:0px;">In addition to a D&I process model, other aspects of D&I research, like those listed below, should be included in the application to strongly address the aims of the application and the purpose of this funding opportunity. Examples of core D&I research elements include but are not limited to:</p><ul><li>D&I theories, models and frameworks (e.g., theories or frameworks that guide understanding of the multi-level contextual factors that influence dissemination and implementation)</li><li>D&I strategies (i.e., methods or techniques used to enhance the dissemination, adoption, implementation, and sustainability of a clinical program or practice)</li><li>D&I outcomes and outcome measures (e.g., acceptability, appropriateness, cost, feasibility, adoption, fidelity, reach/penetration, maintenance/sustainment/sustainability) as well as health service outcomes and outcome measures (e.g., quality, disparity)</li><li>Community engaged research approaches (i.e., research approaches that involve community partners to assist in guiding the research project, such as community advisory boards, co-design approaches, and community-based participatory research), including effective methods of involving individuals with communication disorders</li><li>Qualitative and mixed methods, including methods appropriate for data from individuals with communication disorders</li><li>Theories and methods to understand and reduce or eliminate health disparities, improving care and outcomes</li></ul><p style="margin-left:0px;">A D&I process model and other core D&I research elements should guide the research goals of the application. Examples of relevant early-stage D&I research goals, identified in multiple D&I process models, include, but are not limited to studies that aim to use:</p><ul><li>A community-engaged research approach along with qualitative methods to understand the health needs of individuals and/or service-delivery needs of organizations and identify potential EBIs to address those needs</li><li>A determinants framework and a mixed-methods approach to identify potential individual- and systems-level barriers and facilitators to implementing an EBI in one or more real world contexts</li><li>A community-engaged research approach along with qualitative methods to co-develop and evaluate preliminary D&I strategies intended to support integration of an EBI into practice</li><li>The core functions and forms framework along with qualitative methods to differentiate underlying active ingredients in an EBI and then use a community-engaged research approach to develop and evaluate a community-adapted version of the EBI</li><li>A mixed-methods approach to identify which D&I outcomes and health service delivery outcomes are meaningful to partners and use a community-engaged research approach to co-develop and execute a measurement plan to establish baseline performance</li><li>A community-engaged research approach along with mixed methods to identify and quantify health disparities and identify or develop EBIs to reduce disparities</li><li>A determinants framework and a mixed-methods approach to identify potential individual- and systems-level barriers and facilitators related to disparities in implementation of an EBI in one or more real world contexts</li></ul><p style="margin-left:0px;">Clinical trials are optional for this funding opportunity. Responsive applications include those that (1) don't include clinical trials, (2) include low-risk clinical trials, or (3) include Basic Science Experimental Studies involving Humans (BESH). Low-risk clinical trials must meet ALL the following criteria: meet the budget limits of this NOFO, not require FDA oversight, are not intended to formally establish efficacy and have low risks to potentially cause physical or psychological harm. BESH clinical trials meet the NIH definition of a clinical trial and also meet the definition of basic research.</p><p style="margin-left:0px;"><strong>Consultation with NIDCD Staff Highly Encouraged Prior to Application</strong></p><p style="margin-left:0px;">Given the required elements outlined above, prospective applicants are strongly encouraged to communicate with the scientific/research contact listed at the end of this NOFO as early as possible to discuss how their application will incorporate all required elements. Non-responsive applications (i.e., those that do not include all required elements) will be withdrawn prior to review.</p><p style="margin-left:0px;"><strong>Non-Responsive Applications</strong></p><p style="margin-left:0px;">The following studies will be considered non-responsive for this funding opportunity and will not be reviewed:</p><ul><li>Studies that fail to integrate a D&I process model into the application</li><li>Studies that fail to use other core D&I research elements (e.g., D&I theories/models/frameworks, D&I strategies, D&I outcomes/outcome measures, community engaged research, qualitative/mixed methods, health disparity theories/methods)</li><li>Studies that focus solely on efficacy or effectiveness research without any D&I elements</li><li>Studies outside NIDCD mission areas</li></ul>
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<div data-element-id="261249" data-element-has-label="false" data-element-required="false" data-element-has-value="true" data-section-code="FOD" data-element-type="TEXT">
<a id='_bookmark261249' tabindex='-1' aria-hidden='true'></a><p>Investigators proposing NIH-defined clinical trials may refer to the <a href="https://researchmethodsresources.nih.gov/">Research Methods Resources</a> website for information about developing statistical methods and study designs.</p>
</div>
<div data-element-id="261250" data-element-has-label="false" data-element-required="true" data-element-has-value="true" data-section-code="FOD" data-element-type="TEXT">
<a id='_bookmark261250' tabindex='-1' aria-hidden='true'></a><p>See <a href="#_Section_VIII._Other">Section VIII. Other Information</a> for award authorities and regulations.</p>
</div>
<div data-element-id="261251" data-element-has-label="false" data-element-required="true" data-element-has-value="true" data-section-code="AI" data-element-type="TEXT">
<a id='_bookmark261251' tabindex='-1' aria-hidden='true'></a><a name="_Section II. Award Information"></a><h2>Section II. Award Information</h2>
</div>
<div class="row" data-index="40">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="261252" data-element-required="true" data-element-has-value="true" data-section-code="AI" data-element-type="TEXT">
<a id='_bookmark261252' tabindex='-1' aria-hidden='true'></a>Funding Instrument
</div>
<div class=" col-md-8 datacolumn">
<p>Grant: A financial assistance mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity.</p>
</div>
</div>
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<div class="col-md-4 datalabel" tabindex="0" data-element-id="261253" data-element-required="true" data-element-has-value="true" data-section-code="AI" data-element-type="LINKED_ELEMENT">
<a id='_bookmark261253' tabindex='-1' aria-hidden='true'></a> Application Types Allowed
</div>
<div class=" col-md-8 datacolumn">
New
<br>
Resubmission
<br>
</div>
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<div class="col-md-push-4 col-md-8 datacolumn">
<a id='_bookmark261255' tabindex='-1' aria-hidden='true'></a><p>The <a href="http://grants.nih.gov/grants/guide/url_redirect.htm?id=11116">OER Glossary</a> and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.</p>
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<div class="col-md-4 datalabel" tabindex="0" data-element-id="261256" data-element-required="false" data-element-has-value="true" data-section-code="AI" data-element-type="TEXT">
<a id='_bookmark261256' tabindex='-1' aria-hidden='true'></a>Clinical Trial?
</div>
<div class=" col-md-8 datacolumn">
<p>Optional: Accepting applications that either propose or do not propose clinical trial(s).</p>
</div>
</div>
<div class="row" data-index="45">
<div class="col-md-push-4 col-md-8 datacolumn">
<a id='_bookmark261257' tabindex='-1' aria-hidden='true'></a><p><a href="https://grants.nih.gov/grants/guide/url_redirect.htm?id=82370">Need help determining whether you are doing a clinical trial?</a></p>
</div>
</div>
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<div class="col-md-4 datalabel" tabindex="0" data-element-id="261258" data-element-required="true" data-element-has-value="true" data-section-code="AI" data-element-type="TEXT">
<a id='_bookmark261258' tabindex='-1' aria-hidden='true'></a>Funds Available and Anticipated Number of Awards
</div>
<div class=" col-md-8 datacolumn">
<p>NIDCD intends to commit approximately $1 million per year for this Notice of Funding Opportunity. Awards issued under this funding opportunity are contingent upon the availability of funds, fiscal and programmatic interests and priorities of NIDCD, and the submission of a sufficient number of meritorious applications.</p>
</div>
</div>
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<div class="col-md-4 datalabel" tabindex="0" data-element-id="261259" data-element-required="true" data-element-has-value="true" data-section-code="AI" data-element-type="TEXT">
<a id='_bookmark261259' tabindex='-1' aria-hidden='true'></a>Award Budget
</div>
<div class=" col-md-8 datacolumn">
<p>The combined budget for direct costs for the two-year project period may not exceed $275,000. No more than $200,000 direct costs may be requested in any single year</p>
</div>
</div>
<div class="row" data-index="48">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="261260" data-element-required="true" data-element-has-value="true" data-section-code="AI" data-element-type="TEXT">
<a id='_bookmark261260' tabindex='-1' aria-hidden='true'></a>Award Project Period
</div>
<div class=" col-md-8 datacolumn">
<p>The total project period may not exceed 2 years.</p>
</div>
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<div data-element-id="261261" data-element-has-label="false" data-element-required="true" data-element-has-value="true" data-section-code="AI" data-element-type="TEXT">
<a id='_bookmark261261' tabindex='-1' aria-hidden='true'></a><p>NIH grants policies as described in the <a href="http://grants.nih.gov/grants/guide/url_redirect.htm?id=11120">NIH Grants Policy Statement</a> will apply to the applications submitted and awards made from this NOFO.</p>
</div>
<div data-element-id="261262" data-element-has-label="false" data-element-required="true" data-element-has-value="true" data-section-code="EI" data-element-type="TEXT">
<a id='_bookmark261262' tabindex='-1' aria-hidden='true'></a><a name="_Section III. Eligibility Information"></a><h2>Section III. Eligibility Information</h2>
</div>
<div data-element-id="261263" data-element-has-label="false" data-element-required="true" data-element-has-value="true" data-section-code="EI" data-element-type="TEXT">
<a id='_bookmark261263' tabindex='-1' aria-hidden='true'></a><h4>1. Eligible Applicants</p>
</div>
<div class="heading4" tabindex="0" data-element-id="261264" data-element-required="true" data-element-has-value="true" data-section-code="EI" data-element-type="TEXT">
<a id='_bookmark261264' tabindex='-1' aria-hidden='true'></a>Eligible Organizations
</div>
<div data-element-id="261264" data-element-has-label="true" data-element-required="true" data-element-has-value="true" data-section-code="EI" data-element-type="TEXT">
<p>Higher Education Institutions - Includes all types</p><ul><li>Public/State Controlled Institutions of Higher Education</li><li>Private Institutions of Higher Education</li></ul><p>Nonprofits Other Than Institutions of Higher Education</p><ul><li>Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Higher Education)</li><li>Nonprofits without 501(c)(3) IRS Status (Other than Institutions of Higher Education)</li></ul><p>For-Profit Organizations</p><ul><li>Small Businesses</li><li>For-Profit Organizations (Other than Small Businesses)</li></ul><p>Local Governments</p><ul><li>State Governments</li><li>County Governments</li><li>City or Township Governments</li><li>Special District Governments</li><li>Indian/Native American Tribal Governments (Federally Recognized)</li><li>Indian/Native American Tribal Governments (Other than Federally Recognized).</li></ul>
</div>
<div data-element-id="261265" data-element-has-label="false" data-element-required="false" data-element-has-value="true" data-section-code="EI" data-element-type="TEXT">
<a id='_bookmark261265' tabindex='-1' aria-hidden='true'></a><p>Federal Governments</p>
<ul>
<li>Eligible Agencies of the Federal Government</li>
<li>U.S. Territory or Possession</li>
</ul>
</div>
<div data-element-id="261266" data-element-has-label="false" data-element-required="false" data-element-has-value="true" data-section-code="EI" data-element-type="TEXT">
<a id='_bookmark261266' tabindex='-1' aria-hidden='true'></a><p>Other</p>
<ul>
<li>Independent School Districts</li>
<li>Public Housing Authorities/Indian Housing Authorities</li>
<li>Native American Tribal Organizations (other than Federally recognized tribal governments)</li>
<li>Faith-based or Community-based Organizations</li>
<li>Regional Organizations</li>
<li>Non-domestic (non-U.S.) Entities (Foreign Organizations)</li>
</ul>
</div>
<div data-element-id="261267" data-element-has-label="false" data-element-required="false" data-element-has-value="false" data-section-code="EI" data-element-type="TEXT">
</div>
<div data-element-id="261268" data-element-has-label="false" data-element-required="true" data-element-has-value="true" data-section-code="EI" data-element-type="TEXT">
<a id='_bookmark261268' tabindex='-1' aria-hidden='true'></a><h4>Foreign Organizations/International Collaborations</h4>
</div>
<div data-element-id="261269" data-element-has-label="false" data-element-required="true" data-element-has-value="true" data-section-code="EI" data-element-type="RADIO_BUTTON">
<a id='_bookmark261269' tabindex='-1' aria-hidden='true'></a><p class="Normal">Non-domestic (non-U.S.) Entities (Foreign Organizations) <strong>are </strong>eligible to apply.</p>
</div>
<div data-element-id="261270" data-element-has-label="false" data-element-required="true" data-element-has-value="true" data-section-code="EI" data-element-type="RADIO_BUTTON">
<a id='_bookmark261270' tabindex='-1' aria-hidden='true'></a><p>Non-domestic (non-U.S.) components of U.S. Organizations <strong>are </strong>eligible to apply.</p>
</div>
<div data-element-id="261271" data-element-has-label="false" data-element-required="true" data-element-has-value="true" data-section-code="EI" data-element-type="RADIO_BUTTON">
<a id='_bookmark261271' tabindex='-1' aria-hidden='true'></a><p class="Normal">Foreign components, as <a href="http://grants.nih.gov/grants/guide/url_redirect.htm?id=11118">defined in the NIH Grants Policy Statement</a>, <b>are </b>allowed.</p>
</div>
<div data-element-id="262147" data-element-has-label="false" data-element-required="true" data-element-has-value="true" data-section-code="EI" data-element-type="TEXT">
<a id='_bookmark262147' tabindex='-1' aria-hidden='true'></a><p>NIH will no longer issue awards (i.e., new, renewal, or non-competing continuation) to domestic or foreign entities that involve foreign subawards/subcontracts. All NIH-funded research involving foreign subawards/subcontracts must be submitted in response to a NOFO that is specifically designated for funded international collaborations. This new requirement was effective, May 1, 2025.</p><p>Applications involving foreign subawards/subcontracts submitted in response to this NOFO will be deemed noncompliant and will not be considered for funding. This policy applies to all monetary international collaborations resulting in foreign subawards/subcontracts, however, it does not preclude unfunded international collaborations or <a href="https://grants.nih.gov/grants/policy/nihgps/HTML5/section_1/1.2_definition_of_terms.htm">foreign components</a>, funding for foreign consultants, or procurement of unique equipment or supplies from foreign vendors.</p>
</div>
<div class="heading4" tabindex="0" data-element-id="261272" data-element-required="true" data-element-has-value="true" data-section-code="EI" data-element-type="TEXT">
<a id='_bookmark261272' tabindex='-1' aria-hidden='true'></a>Required Registrations
</div>
<div data-element-id="261272" data-element-has-label="true" data-element-required="true" data-element-has-value="true" data-section-code="EI" data-element-type="TEXT">
<p><strong>Applicant Organizations</strong></p>
<p>Applicant organizations must complete and maintain the following registrations as described in the How to Apply- Application Guide to be eligible to apply for or receive an award. All registrations must be completed prior to the application being submitted. Registration can take 6 weeks or more, so applicants should begin the registration process as soon as possible. Failure to complete registrations in advance of a due date is not a valid reason for a late submission, please reference the <a href="http://grants.nih.gov/grants/guide/url_redirect.htm?id=82423">NIH Grants Policy Statement Section 2.3.9.2 Electronically Submitted Applications</a> for additional information.</p>
<ul>
<li><a href="https://grants.nih.gov/grants/guide/url_redirect.htm?id=82390">System for Award Management (SAM) –</a> Applicants must complete and maintain an active registration, <strong>which requires renewal at least annually</strong>. The renewal process may require as much time as the initial registration. SAM registration includes the assignment of a Commercial and Government Entity (CAGE) Code for domestic organizations which have not already been assigned a CAGE Code.
<ul>
<li><a href="http://grants.nih.gov/grants/guide/url_redirect.htm?id=11176">NATO Commercial and Government Entity (NCAGE) Code</a> – Foreign organizations must obtain an NCAGE code (in lieu of a CAGE code) in order to register in SAM.</li>
<li>Unique Entity Identifier (UEI) - A UEI is issued as part of the SAM.gov registration process. The same UEI must be used for all registrations, as well as on the grant application.</li>
</ul>
</li>
<li><a href="https://grants.nih.gov/grants/guide/url_redirect.htm?id=11123">eRA Commons</a> - Once the unique organization identifier is established, organizations can register with eRA Commons in tandem with completing their Grants.gov registrations; all registrations must be in place by time of submission. eRA Commons requires organizations to identify at least one Signing Official (SO) and at least one Program Director/Principal Investigator (PD/PI) account in order to submit an application.</li>
<li><a href="http://grants.nih.gov/grants/guide/url_redirect.htm?id=82300">Grants.gov</a> – Applicants must have an active SAM registration in order to complete the Grants.gov registration.</li>
</ul>
<p><strong>Program Directors/Principal Investigators (PD(s)/PI(s))</strong></p>
<p>All PD(s)/PI(s) must have an eRA Commons account. PD(s)/PI(s) should work with their organizational officials to either create a new account or to affiliate their existing account with the applicant organization in eRA Commons. If the PD/PI is also the organizational Signing Official, they must have two distinct eRA Commons accounts, one for each role. Obtaining an eRA Commons account can take up to 2 weeks.</p>
</div>
<div class="heading4" tabindex="0" data-element-id="261273" data-element-required="true" data-element-has-value="true" data-section-code="EI" data-element-type="TEXT">
<a id='_bookmark261273' tabindex='-1' aria-hidden='true'></a>Eligible Individuals (Program Director/Principal Investigator)
</div>
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<p>Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with their organization to develop an application for support.</p><p>For institutions/organizations proposing multiple PDs/PIs, visit the Multiple Program Director/Principal Investigator Policy and submission details in the Senior/Key Person Profile (Expanded) Component of the How to Apply-Application Guide.</p>
</div>
<div data-element-id="261274" data-element-has-label="false" data-element-required="false" data-element-has-value="false" data-section-code="EI" data-element-type="TEXT">
</div>
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<a id='_bookmark261275' tabindex='-1' aria-hidden='true'></a><h4>2. Cost Sharing</h4><p>This NOFO does not require cost sharing as defined in the <a href="http://grants.nih.gov/grants/guide/url_redirect.htm?id=11126">NIH Grants Policy Statement Section 1.2 Definition of Terms</a>.</p>
</div>
<div data-element-id="261276" data-element-has-label="false" data-element-required="true" data-element-has-value="true" data-section-code="EI" data-element-type="TEXT">
<a id='_bookmark261276' tabindex='-1' aria-hidden='true'></a><h4>3. Additional Information on Eligibility</h4><p>Number of Applications</p>
</div>
<div data-element-id="261277" data-element-has-label="false" data-element-required="true" data-element-has-value="true" data-section-code="EI" data-element-type="TEXT">
<a id='_bookmark261277' tabindex='-1' aria-hidden='true'></a><p>Applicant organizations may submit more than one application, provided that each application is scientifically distinct.</p>
<p>The NIH will not accept duplicate or highly overlapping applications under review at the same time, per <a href="http://grants.nih.gov/grants/guide/url_redirect.htm?id=82415">NIH Grants Policy Statement Section 2.3.7.4 Submission of Resubmission Application</a>. This means that the NIH will not accept:</p>
<ul>
<li>A new (A0) application that is submitted before issuance of the summary statement from the review of an overlapping new (A0) or resubmission (A1) application.</li>
<li>A resubmission (A1) application that is submitted before issuance of the summary statement from the review of the pr
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